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A Multi-Task Targeted Learning Framework for Lithium-Ion Battery State-of-Health and Remaining Useful Life

arXiv:2603.22323v1 Announce Type: cross Abstract: Accurately predicting the state-of-health (SOH) and remaining useful life (RUL) of lithium-ion batteries is crucial for ensuring the safe and efficient operation of electric vehicles while minimizing associated risks. However, current deep learning methods are limited in their ability to selectively extract features and model time dependencies for these two parameters. Moreover, most existing methods rely on traditional recurrent neural networks, which have inherent shortcomings in long-term time-series modeling. To address these issues, this paper proposes a multi-task targeted learning framework for SOH and RUL prediction, which integrates multiple neural networks, including a multi-scale feature extraction module, an improved extended LSTM, and a dual-stream attention module. First, a feature extraction module with multi-scale CNNs is designed to capture detailed local battery decline patterns. Secondly, an improved extended LSTM network is employed to enhance the model's ability to retain long-term temporal information, thus improving temporal relationship modeling. Building on this, the dual-stream attention module-comprising polarized attention and sparse attention to selectively focus on key information relevant to SOH and RUL, respectively, by assigning higher weights to important features. Finally, a many-to-two mapping is achieved through the dual-task layer. To optimize the model's performance and reduce the need for manual hyperparameter tuning, the Hyperopt optimization algorithm is used. Extensive comparative experiments on battery aging datasets demonstrate that the proposed method reduces the average RMSE for SOH and RUL predictions by 111.3\% and 33.0\%, respectively, compared to traditional and state-of-the-art methods.
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Overcoming missing data in spatial metabolomics with machine learning imputation to accelerate downstream discovery

iScience. 2026 Mar 3;29(4):115203. doi: 10.1016/j.isci.2026.115203. eCollection 2026 Apr 17.

ABSTRACT

Mass spectrometry imaging (MSI)-based spatial metabolomics exhibits extensive missing values; yet, practical guidance on how imputation choices affect both imputation accuracy and downstream spatial analyses remains limited. In this study, we evaluated eight imputation methods, including both existing approaches and a graph convolutional network (GCN)-based method specifically designed for spatial metabolomics data, to identify suitable approaches for spatial metabolomics. To enable comprehensive assessment, we developed an evaluation framework focusing on two objective criteria: (a) imputation accuracy and (b) preservation of spatial cluster structure. We assembled six benchmark datasets spanning mouse brain and liver, human kidney and stomach, and plant seed sections, and conducted controlled dropout simulations of missing values. Across both evaluation dimensions, including imputation accuracy and preservation of spatial cluster structure, RF ranked first overall, and GCN ranked second in both dimensions. Overall, this systematic, dual-perspective benchmark study provides guidance for selecting imputation strategies in spatial metabolomics research.

PMID:41869568 | PMC:PMC12999350 | DOI:10.1016/j.isci.2026.115203

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Low-dose intestinal irradiation enhances the efficacy and prognosis of PD-1 blockade in metastatic non-small cell lung cancer

Clin Cancer Res. 2026 Mar 18. doi: 10.1158/1078-0432.CCR-25-4153. Online ahead of print.

ABSTRACT

PURPOSE: Intestinal low-dose irradiation (ILDR) may enhance immunotherapy efficacy by modulating the gut microbiota and metabolism; however, its role in metastatic non-small cell lung cancer (mNSCLC), particularly in the first-line setting, remains unclear.

EXPERIMENTAL DESIGN: This multicenter retrospective and prospective study included mNSCLC patients receiving first- and second-line programmed cell death protein 1 (PD-1) inhibitors along with abdominopelvic radiotherapy between 2018 and 2025. Patients were stratified by the mean intestinal radiation dose into <1 Gy, 1-3 Gy, and >3 Gy groups and treatment outcomes were compared. The blood and fecal samples were subjected to multi-omics profiling.

RESULTS: g>309 patients were included in the retrospective analysis. Optimal efficacy was observed with a small intestinal mean radiation dose (SIMRD) of 1-3 Gy, showing longer progression-free survival (PFS, 10.2 months) and overall survival (OS, 22.8 months) (P < 0.01), which was consistent across subgroups. Compared with 1-3 Gy, SIMRD >3 Gy (Hazard ratio [HR] = 4.87, P < 0.001) and <1 Gy (HR = 1.85, P < 0.001) independently predicted worse OS. Prospective results confirmed the best disease control rate (P = 0.041) and PFS (P = 0.046) with SIMRD of 1-3 Gy. Responders were enriched in Bacillota, Clostridia, and indole derivatives, particularly indole-3-carboxylic acid. Moreover, the 1-3 Gy group exhibited increased circulating macrophage inflammatory protein-3Ξ± and reduced circulating Ξ±4Ξ²7+ regulatory T cells.

CONCLUSIONS: ILDR influences the efficacy of PD-1 blockade in patients with mNSCLC, particularly when SIMRD is maintained within the 1-3 Gy range, likely through modulation of the gut microbiota-metabolite-immune axis.

PMID:41849236 | DOI:10.1158/1078-0432.CCR-25-4153

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Tuning the sensitivity of mechanosensory receptors through histidine scanning

Histidine scanning represents a broadly applicable technique for the identification of critical interaction sites within TCRs and other mechanosensory receptors to enhance receptor signaling strength and augment therapeutic efficacy via the catch bond mechanism.
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