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Mean Masked Autoencoder with Flow-Mixing for Encrypted Traffic Classification

arXiv:2603.29537v1 Announce Type: cross Abstract: Network traffic classification using self-supervised pre-training models based on Masked Autoencoders (MAE) has demonstrated a huge potential. However, existing methods are confined to isolated byte-level reconstruction of individual flows, lacking adequate perception of the multi-granularity contextual relationship in traffic. To address this limitation, we propose Mean MAE (MMAE), a teacher-student MAE paradigm with flow mixing strategy for building encrypted traffic pre-training model. MMAE employs a self-distillation mechanism for teacher-student interaction, where the teacher provides unmasked flow-level semantic supervision to advance the student from local byte reconstruction to multi-granularity comprehension. To break the information bottleneck in individual flows, we introduce a dynamic Flow Mixing (FlowMix) strategy to replace traditional random masking mechanism. By constructing challenging cross-flow mixed samples with interferences, it compels the model to learn discriminative representations from distorted tokens. Furthermore, we design a Packet-importance aware Mask Predictor (PMP) equipped with an attention bias mechanism that leverages packet-level side-channel statistics to dynamically mask tokens with high semantic density. Numerous experiments on a number of datasets covering encrypted applications, malware, and attack traffic demonstrate that MMAE achieves state-of-the-art performance. The code is available at https://github.com/lx6c78/MMAE
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LDHA-driven lactate metabolism promotes MDSC activation and immunosuppressive microenvironment in prostate cancer

Oncogene, Published online: 01 April 2026; doi:10.1038/s41388-026-03737-5

LDHA-driven lactate metabolism promotes MDSC activation and immunosuppressive microenvironment in prostate cancer
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Two-step clinical care pathway to predict MASLD-related advanced fibrosis and long-term outcomes in type 2 diabetes

Gut. 2026 Feb 9;75(3):576-587. doi: 10.1136/gutjnl-2025-337506.

ABSTRACT

BACKGROUND: Current guidelines recommend a two-step approach for risk stratification of metabolic dysfunction-associated steatotic liver disease (MASLD), starting with Fibrosis-4 index (FIB-4) followed by liver stiffness measurement (LSM) using vibration-controlled transient elastography (VCTE).

OBJECTIVE: To evaluate this approach for predicting advanced fibrosis and liver-related events (LREs) in patients with type 2 diabetes (T2D).

DESIGN: A prospective liver biopsy cohort of T2D patients with histologically confirmed MASLD from seven centres in China was used to assess diagnostic performance for advanced fibrosis. The international VCTE-Prognosis cohort, including T2D patients with MASLD who underwent VCTE at 16 centres in the USA, Europe and Asia, with longitudinal follow-up, was used to assess LREs, defined as hepatic decompensation or hepatocellular carcinoma.

RESULTS: 4781 participants were included. In the liver biopsy cohort (n=352; 22.2% with advanced fibrosis), applying LSM thresholds of <8 kPa and >12 kPa after FIB-4 classified patients into 63.4% low-risk, 9.4% intermediate-risk and 27.3% high-risk, with a correct classification rate of 71%. In the VCTE-Prognosis cohort (n=4429; median follow-up 51.3 (IQR 27.4-70.7) months), 140 (3.2%) patients developed LREs (110 (2.5%) with hepatic decompensation and 59 (1.3%) with hepatocellular carcinoma). The two-step approach classified 72.6%, 6.8% and 20.6% of patients into low-risk, intermediate-risk and high-risk groups, with corresponding 5-year cumulative LRE incidences of 0.7%, 0.9% and 11.8%. Refining classification of intermediate FIB-4 patients using LSM <10 kPa (low-risk) and >15 kPa (high-risk) reduced the intermediate-risk group to 5.6% while preserving predictive accuracy.

CONCLUSION: The non-invasive two-step approach of FIB-4 followed by LSM effectively stratifies MASLD-related advanced fibrosis and LREs risk in T2D. Applying LSM cut-offs of 10 and 15 kPa further optimises risk stratification for future LREs.

PMID:41911049 | DOI:10.1136/gutjnl-2025-337506

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