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PAR$^2$-RAG: Planned Active Retrieval and Reasoning for Multi-Hop Question Answering

arXiv:2603.29085v1 Announce Type: new Abstract: Large language models (LLMs) remain brittle on multi-hop question answering (MHQA), where answering requires combining evidence across documents through retrieval and reasoning. Iterative retrieval systems can fail by locking onto an early low-recall trajectory and amplifying downstream errors, while planning-only approaches may produce static query sets that cannot adapt when intermediate evidence changes. We propose \textbf{Planned Active Retrieval and Reasoning RAG (PAR$^2$-RAG)}, a two-stage framework that separates \emph{coverage} from \emph{commitment}. PAR$^2$-RAG first performs breadth-first anchoring to build a high-recall evidence frontier, then applies depth-first refinement with evidence sufficiency control in an iterative loop. Across four MHQA benchmarks, PAR$^2$-RAG consistently outperforms existing state-of-the-art baselines, compared with IRCoT, PAR$^2$-RAG achieves up to \textbf{23.5\%} higher accuracy, with retrieval gains of up to \textbf{10.5\%} in NDCG.
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Webscraper: Leverage Multimodal Large Language Models for Index-Content Web Scraping

arXiv:2603.29161v1 Announce Type: new Abstract: Modern web scraping struggles with dynamic, interactive websites that require more than static HTML parsing. Current methods are often brittle and require manual customization for each site. To address this, we introduce Webscraper, a framework designed to handle the challenges of modern, dynamic web applications. It leverages a Multimodal Large Language Model (MLLM) to autonomously navigate interactive interfaces, invoke specialized tools, and perform structured data extraction in environments where traditional scrapers are ineffective. Webscraper utilizes a structured five-stage prompting procedure and a set of custom-built tools to navigate and extract data from websites following the common ``index-and-content'' architecture. Our experiments, conducted on six news websites, demonstrate that the full Webscraper framework, equipped with both our guiding prompt and specialized tools, achieves a significant improvement in extraction accuracy over the baseline agent Anthropic's Computer Use. We also applied the framework to e-commerce platforms to validate its generalizability.
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Xuanwu: Evolving General Multimodal Models into an Industrial-Grade Foundation for Content Ecosystems

arXiv:2603.29211v1 Announce Type: new Abstract: In recent years, multimodal large models have continued to improve on general benchmarks. However, in real-world content moderation and adversarial settings, mainstream models still suffer from degraded generalization and catastrophic forgetting because of limited fine-grained visual perception and insufficient modeling of long-tail noise. In this paper, we present Xuanwu VL-2B as a case study of how general multimodal models can be developed into an industrial-grade foundation model for content ecosystems. The model adopts a compact InternViT-300M + MLP + Qwen3 1.7B architecture, balancing fine-grained visual perception, language-semantic alignment, and deployment cost within an approximately 2B-parameter budget. To balance business specialization with the retention of general capabilities, we developed a data iteration and curation mechanism and trained the model through a progressive three-stage pipeline: pre-training, mid-training, and post-training. Ablation studies and offline business evaluations show that Xuanwu VL-2B achieves an average score of 67.90 across seven OpenCompass multimodal metrics (vs. 64.27 for InternVL 3.5 2B), an average recall of 94.38% over seven independent business moderation tasks, and a weighted overall recall of 82.82% on policy-violating text in challenging adversarial OCR scenarios, outperforming Gemini-2.5-Pro (76.72%). These results show that, under a limited parameter budget, Xuanwu VL-2B achieves a practical balance among business alignment, visual perception, general capability retention, and deployment cost.
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ATP-Bench: Towards Agentic Tool Planning for MLLM Interleaved Generation

arXiv:2603.29902v1 Announce Type: new Abstract: Interleaved text-and-image generation represents a significant frontier for Multimodal Large Language Models (MLLMs), offering a more intuitive way to convey complex information. Current paradigms rely on either image generation or retrieval augmentation, yet they typically treat the two as mutually exclusive paths, failing to unify factuality with creativity. We argue that the next milestone in this field is Agentic Tool Planning, where the model serves as a central controller that autonomously determines when, where, and which tools to invoke to produce interleaved responses for visual-critical queries. To systematically evaluate this paradigm, we introduce ATP-Bench, a novel benchmark comprising 7,702 QA pairs (including 1,592 VQA pairs) across eight categories and 25 visual-critical intents, featuring human-verified queries and ground truths. Furthermore, to evaluate agentic planning independent of end-to-end execution and changing tool backends, we propose a Multi-Agent MLLM-as-a-Judge (MAM) system. MAM evaluates tool-call precision, identifies missed opportunities for tool use, and assesses overall response quality without requiring ground-truth references. Our extensive experiments on 10 state-of-the-art MLLMs reveal that models struggle with coherent interleaved planning and exhibit significant variations in tool-use behavior, highlighting substantial room for improvement and providing actionable guidance for advancing interleaved generation. Dataset and code are available at https://github.com/Qwen-Applications/ATP-Bench.
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C-TRAIL: A Commonsense World Framework for Trajectory Planning in Autonomous Driving

arXiv:2603.29908v1 Announce Type: new Abstract: Trajectory planning for autonomous driving increasingly leverages large language models (LLMs) for commonsense reasoning, yet LLM outputs are inherently unreliable, posing risks in safety-critical applications. We propose C-TRAIL, a framework built on a Commonsense World that couples LLM-derived commonsense with a trust mechanism to guide trajectory planning. C-TRAIL operates through a closed-loop Recall, Plan, and Update cycle: the Recall module queries an LLM for semantic relations and quantifies their reliability via a dual-trust mechanism; the Plan module injects trust-weighted commonsense into Monte Carlo Tree Search (MCTS) through a Dirichlet trust policy; and the Update module adaptively refines trust scores and policy parameters from environmental feedback. Experiments on four simulated scenarios in Highway-env and two real-world levelXData datasets (highD, rounD) show that C-TRAIL consistently outperforms state-of-the-art baselines, reducing ADE by 40.2%, FDE by 51.7%, and improving SR by 16.9 percentage points on average. The source code is available at https://github.com/ZhihongCui/CTRAIL.
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Human-Like Lifelong Memory: A Neuroscience-Grounded Architecture for Infinite Interaction

arXiv:2603.29023v1 Announce Type: cross Abstract: Large language models lack persistent, structured memory for long-term interaction and context-sensitive retrieval. Expanding context windows does not solve this: recent evidence shows that context length alone degrades reasoning by up to 85% - even with perfect retrieval. We propose a bio-inspired memory framework grounded in complementary learning systems theory, cognitive behavioral therapy's belief hierarchy, dual-process cognition, and fuzzy-trace theory, organized around three principles: (1) Memory has valence, not just content - pre-computed emotional-associative summaries (valence vectors) organized in an emergent belief hierarchy inspired by Beck's cognitive model enable instant orientation before deliberation; (2) Retrieval defaults to System 1 with System 2 escalation - automatic spreading activation and passive priming as default, with deliberate retrieval only when needed, and graded epistemic states that address hallucination structurally; and (3) Encoding is active, present, and feedback-dependent - a thalamic gateway tags and routes information between stores, while the executive forms gists through curiosity-driven investigation, not passive exposure. Seven functional properties specify what any implementation must satisfy. Over time, the system converges toward System 1 processing - the computational analog of clinical expertise - producing interactions that become cheaper, not more expensive, with experience.
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Efficient and Scalable Granular-ball Graph Coarsening Method for Large-scale Graph Node Classification

arXiv:2603.29148v1 Announce Type: cross Abstract: Graph Convolutional Network (GCN) is a model that can effectively handle graph data tasks and has been successfully applied. However, for large-scale graph datasets, GCN still faces the challenge of high computational overhead, especially when the number of convolutional layers in the graph is large. Currently, there are many advanced methods that use various sampling techniques or graph coarsening techniques to alleviate the inconvenience caused during training. However, among these methods, some ignore the multi-granularity information in the graph structure, and the time complexity of some coarsening methods is still relatively high. In response to these issues, based on our previous work, in this paper, we propose a new framework called Efficient and Scalable Granular-ball Graph Coarsening Method for Large-scale Graph Node Classification. Specifically, this method first uses a multi-granularity granular-ball graph coarsening algorithm to coarsen the original graph to obtain many subgraphs. The time complexity of this stage is linear and much lower than that of the exiting graph coarsening methods. Then, subgraphs composed of these granular-balls are randomly sampled to form minibatches for training GCN. Our algorithm can adaptively and significantly reduce the scale of the original graph, thereby enhancing the training efficiency and scalability of GCN. Ultimately, the experimental results of node classification on multiple datasets demonstrate that the method proposed in this paper exhibits superior performance. The code is available at https://anonymous.4open.science/r/1-141D/.
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IMPACT: Influence Modeling for Open-Set Time Series Anomaly Detection

arXiv:2603.29183v1 Announce Type: cross Abstract: Open-set anomaly detection (OSAD) is an emerging paradigm designed to utilize limited labeled data from anomaly classes seen in training to identify both seen and unseen anomalies during testing. Current approaches rely on simple augmentation methods to generate pseudo anomalies that replicate unseen anomalies. Despite being promising in image data, these methods are found to be ineffective in time series data due to the failure to preserve its sequential nature, resulting in trivial or unrealistic anomaly patterns. They are further plagued when the training data is contaminated with unlabeled anomalies. This work introduces $\textbf{IMPACT}$, a novel framework that leverages $\underline{\textbf{i}}$nfluence $\underline{\textbf{m}}$odeling for o$\underline{\textbf{p}}$en-set time series $\underline{\textbf{a}}$nomaly dete$\underline{\textbf{ct}}$ion, to tackle these challenges. The key insight is to $\textbf{i)}$ learn an influence function that can accurately estimate the impact of individual training samples on the modeling, and then $\textbf{ii)}$ leverage these influence scores to generate semantically divergent yet realistic unseen anomalies for time series while repurposing high-influential samples as supervised anomalies for anomaly decontamination. Extensive experiments show that IMPACT significantly outperforms existing state-of-the-art methods, showing superior accuracy under varying OSAD settings and contamination rates.
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AGFT: Alignment-Guided Fine-Tuning for Zero-Shot Adversarial Robustness of Vision-Language Models

arXiv:2603.29410v1 Announce Type: cross Abstract: Pre-trained vision-language models (VLMs) exhibit strong zero-shot generalization but remain vulnerable to adversarial perturbations. Existing classification-guided adversarial fine-tuning methods often disrupt pre-trained cross-modal alignment, weakening visual-textual correspondence and degrading zero-shot performance. In this paper, we propose an Alignment-Guided Fine-Tuning (AGFT) framework that enhances zero-shot adversarial robustness while preserving the cross-modal semantic structure. Unlike label-based methods that rely on hard labels and fail to maintain the relative relationships between image and text, AGFT leverages the probabilistic predictions of the original model for text-guided adversarial training, which aligns adversarial visual features with textual embeddings via soft alignment distributions, improving zero-shot adversarial robustness. To address structural discrepancies introduced by fine-tuning, we introduce a distribution consistency calibration mechanism that adjusts the robust model output to match a temperature-scaled version of the pre-trained model predictions. Extensive experiments across multiple zero-shot benchmarks demonstrate that AGFT outperforms state-of-the-art methods while significantly improving zero-shot adversarial robustness.
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MacTok: Robust Continuous Tokenization for Image Generation

arXiv:2603.29634v1 Announce Type: cross Abstract: Continuous image tokenizers enable efficient visual generation, and those based on variational frameworks can learn smooth, structured latent representations through KL regularization. Yet this often leads to posterior collapse when using fewer tokens, where the encoder fails to encode informative features into the compressed latent space. To address this, we introduce \textbf{MacTok}, a \textbf{M}asked \textbf{A}ugmenting 1D \textbf{C}ontinuous \textbf{Tok}enizer that leverages image masking and representation alignment to prevent collapse while learning compact and robust representations. MacTok applies both random masking to regularize latent learning and DINO-guided semantic masking to emphasize informative regions in images, forcing the model to encode robust semantics from incomplete visual evidence. Combined with global and local representation alignment, MacTok preserves rich discriminative information in a highly compressed 1D latent space, requiring only 64 or 128 tokens. On ImageNet, MacTok achieves a competitive gFID of 1.44 at 256$\times$256 and a state-of-the-art 1.52 at 512$\times$512 with SiT-XL, while reducing token usage by up to 64$\times$. These results confirm that masking and semantic guidance together prevent posterior collapse and achieve efficient, high-fidelity tokenization.
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Scalable AI-assisted Workflow Management for Detector Design Optimization Using Distributed Computing

arXiv:2603.30014v1 Announce Type: cross Abstract: The Production and Distributed Analysis (PanDA) system, originally developed for the ATLAS experiment at the CERN Large Hadron Collider (LHC), has evolved into a robust platform for orchestrating large-scale workflows across distributed computing resources. Coupled with its intelligent Distributed Dispatch and Scheduling (iDDS) component, PanDA supports AI/ML-driven workflows through a scalable and flexible workflow engine. We present an AI-assisted framework for detector design optimization that integrates multi-objective Bayesian optimization with the PanDA--iDDS workflow engine to coordinate iterative simulations across heterogeneous resources. The framework addresses the challenge of exploring high-dimensional parameter spaces inherent in modern detector design. We demonstrate the framework using benchmark problems and realistic studies of the ePIC and dRICH detectors for the Electron-Ion Collider (EIC). Results show improved automation, scalability, and efficiency in multi-objective optimization. This work establishes a flexible and extensible paradigm for AI-driven detector design and other computationally intensive scientific applications.
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Trace2Skill: Distill Trajectory-Local Lessons into Transferable Agent Skills

arXiv:2603.25158v3 Announce Type: replace Abstract: Equipping Large Language Model (LLM) agents with domain-specific skills is critical for tackling complex tasks. Yet, manual authoring creates a severe scalability bottleneck. Conversely, automated skill generation often yields fragile or fragmented results because it either relies on shallow parametric knowledge or sequentially overfits to non-generalizable trajectory-local lessons. To overcome this, we introduce Trace2Skill, a framework that mirrors how human experts author skills: by holistically analyzing broad execution experience before distilling it into a single, comprehensive guide. Instead of reacting sequentially to individual trajectories, Trace2Skill dispatches a parallel fleet of sub-agents to analyze a diverse pool of executions. It extracts trajectory-specific lessons and hierarchically consolidates them into a unified, conflict-free skill directory via inductive reasoning. Trace2Skill supports both deepening existing human-written skills and creating new ones from scratch. Experiments in challenging domains, such as spreadsheet, VisionQA and math reasoning, show that Trace2Skill significantly improves upon strong baselines, including Anthropic's official xlsx skills. Crucially, this trajectory-grounded evolution does not merely memorize task instances or model-specific quirks: evolved skills transfer across LLM scales and generalize to OOD settings. For example, skills evolved by Qwen3.5-35B on its own trajectories improved a Qwen3.5-122B agent by up to 57.65 absolute percentage points on WikiTableQuestions. Ultimately, our results demonstrate that complex agent experience can be packaged into highly transferable, declarative skills -- requiring no parameter updates, no external retrieval modules, and utilizing open-source models as small as 35B parameters.
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Balancing Efficiency and Empathy: Healthcare Providers' Perspectives on AI-Supported Workflows for Serious Illness Conversations in the Emergency Department

arXiv:2506.00241v2 Announce Type: replace-cross Abstract: Serious Illness Conversations (SICs), discussions about values and care preferences for patients with life-threatening illness, rarely occur in Emergency Departments (EDs), despite evidence that early conversations improve care alignment and reduce unnecessary interventions. We interviewed 11 ED providers to identify challenges in SICs and opportunities for technology support, with a focus on AI. Our analysis revealed a four-stage SIC workflow (identification, preparation, conduction, documentation) and barriers at each stage, including fragmented patient information, limited time and space, lack of conversational guidance, and burdensome documentation. Providers expressed interest in AI systems for synthesizing information, supporting real-time conversations, and automating documentation, but emphasized concerns about preserving human connection and clinical autonomy. This tension highlights the need for technologies that enhance efficiency without undermining the interpersonal nature of SICs. We propose design guidelines for ambient and peripheral AI systems to support providers while preserving the essential humanity of these conversations.
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VLA Models Are More Generalizable Than You Think: Revisiting Physical and Spatial Modeling

arXiv:2512.02902v2 Announce Type: replace-cross Abstract: Vision-language-action (VLA) models achieve strong in-distribution performance but degrade sharply under novel camera viewpoints and visual perturbations. We show that this brittleness primarily arises from misalignment in Spatial Modeling, rather than Physical Modeling. To address this, we propose a one-shot adaptation framework that recalibrates visual representations through lightweight, learnable updates. Our first method, Feature Token Modulation (FTM), applies a global affine transformation to visual tokens and improves Libero viewpoint accuracy from 48.5% to 87.1% with only 4K parameters. Building on this, Feature Linear Adaptation (FLA) introduces low-rank updates to the ViT encoder, achieving 90.8% success with 4.7M parameters -- matching LoRA-scale finetuning at far lower cost. Together, these results reveal substantial untapped robustness in pretrained VLA models and demonstrate that targeted, minimal visual adaptation is sufficient to restore viewpoint generalization.
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Association Between Telemedicine Adoption and Physician Job Satisfaction: Cross-Sectional Study

Background: Telemedicine has expanded rapidly in recent years, with particularly pronounced growth following the COVID-19 pandemic. By improving access to care and offering greater flexibility in service delivery, it has become an important component of health care. Although the benefits of telemedicine for patients are well documented, its effects on physician job satisfaction remain insufficiently understood. Given the importance of job satisfaction for workforce stability, physician well-being, and quality of care, further examination of how telemedicine affects physician job satisfaction is warranted. Objective: This study aims to examine the association between telemedicine adoption and physician job satisfaction and to assess whether the physician-patient relationship mediates this association. Methods: A cross-sectional survey was conducted among health care professionals in Xi’an, China. Data were collected between November 7 and December 8, 2023, via an online questionnaire administered using the REDCap (Research Electronic Data Capture; Vanderbilt University) platform. A total of 12,052 physicians were included in the analysis. Physician job satisfaction was measured using a validated 6-point Likert scale. Telemedicine adoption was assessed through self-report. A partial proportional odds model was used to examine the association between telemedicine adoption and job satisfaction, adjusting for a comprehensive set of potential confounders. Additionally, the Karlson-Holm-Breen (KHB) decomposition method was used to explore the mediating role of physician-patient relationship quality in this association. Results: Among 12,052 surveyed physicians, 1642 (13.62%) reported adopting telemedicine, whereas 10,410 (86.38%) did not. After adjusting for demographic characteristics, work-related factors, psychological factors, and physician-patient relationship, telemedicine adoption was significantly associated with higher job satisfaction (odds ratio [OR] 1.17, 95% CI 1.05‐1.30). Findings were robust across multiple sensitivity analyses. Subgroup analyses indicated that the association did not vary across physician subgroups, and no significant interaction effects were observed. Mediation analysis revealed a total effect of telemedicine on job satisfaction of 0.33 (95% CI 0.17‐0.50), with an indirect effect of 0.10 (95% CI 0.07‐0.13) through improved physician-patient relationships, accounting for 30.30% of the total effect. Conclusions: These findings suggest that telemedicine adoption is positively associated with physician job satisfaction, partially mediated by the physician-patient relationship. Policies should promote telemedicine adoption while prioritizing platform designs that support effective physician-patient interactions to enhance provider well-being and care outcomes.
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Pathogenesis and immune regulation of rheumatoid arthritis-associated interstitial lung disease: from basic research to clinical implications

Front Immunol. 2026 Mar 13;17:1770348. doi: 10.3389/fimmu.2026.1770348. eCollection 2026.

ABSTRACT

Interstitial lung disease (ILD) is one of the most common extra-articular manifestations of rheumatoid arthritis (RA). Some patients with RA-ILD may develop progressive pulmonary fibrosis, leading to severe impairment of lung function and respiratory failure, which impacts quality of life and can even be life-threatening. This review identified genetic susceptibility, environmental factors, and immune dysregulation as key contributors to the etiology and pathogenesis of RA-ILD. We highlight that autoantibodies, adaptive immune abnormalities, and tertiary lymphoid organ formation significantly drive pulmonary inflammation and fibrosis, while pro-inflammatory cytokines and epithelial-mesenchymal transition (EMT) further contribute to lung tissue injury. Current treatment options, including glucocorticoids, immunosuppressants, and antifibrotic agents such as nintedanib and pirfenidone, are often limited by substantial side effects. Additionally, emerging therapies like JAK inhibitors, CAR-T cells, and the upcoming phosphodiesterase-4B inhibitor, nerandomilast, show promise, but no curative treatment exists to date. Future research could focus on multi-omics technologies and conducting multicenter clinical trials to establish therapeutic targets and advance precision medicine for RA-ILD.

PMID:41909710 | PMC:PMC13021622 | DOI:10.3389/fimmu.2026.1770348

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A unified deep learning framework for cross-platform harmonization of multi-tracer PET quantification in neurodegenerative disease

npj Digital Medicine, Published online: 30 March 2026; doi:10.1038/s41746-026-02570-0

A unified deep learning framework for cross-platform harmonization of multi-tracer PET quantification in neurodegenerative disease
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