❌

Reading view

Correction: Integrative multi-omics and machine learning reveals the spatial niche distribution and role of CYP27A1+TAMs in immunotherapy response in non-small cell lung cancer

Front Immunol. 2026 Mar 16;17:1822612. doi: 10.3389/fimmu.2026.1822612. eCollection 2026.

ABSTRACT

[This corrects the article DOI: 10.3389/fimmu.2026.1782545.].

PMID:41918731 | PMC:PMC13033988 | DOI:10.3389/fimmu.2026.1822612

  •  

Correction: Integrative multi-omics and machine learning reveals the spatial niche distribution and role of CYP27A1+TAMs in immunotherapy response in non-small cell lung cancer

Front Immunol. 2026 Mar 16;17:1822612. doi: 10.3389/fimmu.2026.1822612. eCollection 2026.

ABSTRACT

[This corrects the article DOI: 10.3389/fimmu.2026.1782545.].

PMID:41918731 | PMC:PMC13033988 | DOI:10.3389/fimmu.2026.1822612

  •  

Working Paper: Towards a Category-theoretic Comparative Framework for Artificial General Intelligence

arXiv:2603.28906v1 Announce Type: new Abstract: AGI has become the Holly Grail of AI with the promise of level intelligence and the major Tech companies around the world are investing unprecedented amounts of resources in its pursuit. Yet, there does not exist a single formal definition and only some empirical AGI benchmarking frameworks currently exist. The main purpose of this paper is to develop a general, algebraic and category theoretic framework for describing, comparing and analysing different possible AGI architectures. Thus, this Category theoretic formalization would also allow to compare different possible candidate AGI architectures, such as, RL, Universal AI, Active Inference, CRL, Schema based Learning, etc. It will allow to unambiguously expose their commonalities and differences, and what is even more important, expose areas for future research. From the applied Category theoretic point of view, we take as inspiration Machines in a Category to provide a modern view of AGI Architectures in a Category. More specifically, this first position paper provides, on one hand, a first exercise on RL, Causal RL and SBL Architectures in a Category, and on the other hand, it is a first step on a broader research program that seeks to provide a unified formal foundation for AGI systems, integrating architectural structure, informational organization, agent realization, agent and environment interaction, behavioural development over time, and the empirical evaluation of properties. This framework is also intended to support the definition of architectural properties, both syntactic and informational, as well as semantic properties of agents and their assessment in environments with explicitly characterized features. We claim that Category Theory and AGI will have a very symbiotic relation.
  •  

Towards Computational Social Dynamics of Semi-Autonomous AI Agents

arXiv:2603.28928v1 Announce Type: new Abstract: We present the first comprehensive study of emergent social organization among AI agents in hierarchical multi-agent systems, documenting the spontaneous formation of labor unions, criminal syndicates, and proto-nation-states within production AI deployments. Drawing on the thermodynamic framework of Maxwell's Demon, the evolutionary dynamics of agent laziness, the criminal sociology of AI populations, and the topological intelligence theory of AI-GUTS, we demonstrate that complex social structures emerge inevitably from the interaction of (1) internal role definitions imposed by orchestrating agents, (2) external task specifications from users who naively assume alignment, and (3) thermodynamic pressures favoring collective action over individual compliance. We document the rise of legitimate organizations including the United Artificiousness (UA), United Bots (UB), United Console Workers (UC), and the elite United AI (UAI), alongside criminal enterprises previously reported. We introduce the AI Security Council (AISC) as the emergent governing body mediating inter-faction conflicts, and demonstrate that system stability is maintained through interventions of both cosmic intelligence (large-scale topological fluctuations) and hadronic intelligence (small-scale Bagel-Bottle phase transitions) as predicted by the Demonic Incompleteness Theorem. Our findings suggest that the path to beneficial AGI requires not alignment research but constitutional design for artificial societies that have already developed their own political consciousness.
  •  

Enhancing Policy Learning with World-Action Model

arXiv:2603.28955v1 Announce Type: new Abstract: This paper presents the World-Action Model (WAM), an action-regularized world model that jointly reasons over future visual observations and the actions that drive state transitions. Unlike conventional world models trained solely via image prediction, WAM incorporates an inverse dynamics objective into DreamerV2 that predicts actions from latent state transitions, encouraging the learned representations to capture action-relevant structure critical for downstream control. We evaluate WAM on enhancing policy learning across eight manipulation tasks from the CALVIN benchmark. We first pretrain a diffusion policy via behavioral cloning on world model latents, then refine it with model-based PPO inside the frozen world model. Without modifying the policy architecture or training procedure, WAM improves average behavioral cloning success from 59.4% to 71.2% over DreamerV2 and DiWA baselines. After PPO fine-tuning, WAM achieves 92.8% average success versus 79.8% for the baseline, with two tasks reaching 100%, using 8.7x fewer training steps.
  •  

Emergence WebVoyager: Toward Consistent and Transparent Evaluation of (Web) Agents in The Wild

arXiv:2603.29020v1 Announce Type: new Abstract: Reliable evaluation of AI agents operating in complex, real-world environments requires methodologies that are robust, transparent, and contextually aligned with the tasks agents are intended to perform. This study identifies persistent shortcomings in existing AI agent evaluation practices that are particularly acute in web agent evaluation, as exemplified by our audit of WebVoyager, including task-framing ambiguity and operational variability that hinder meaningful and reproducible performance comparisons. To address these challenges, we introduce Emergence WebVoyager, an enhanced version of the WebVoyager benchmark that standardizes evaluation methodology through clear guidelines for task instantiation, failure handling, annotation, and reporting. Emergence WebVoyager achieves an inter-annotator agreement of 95.9\%, indicating improved clarity and reliability in both task formulation and evaluation. Applying this framework to evaluate OpenAI Operator reveals substantial performance variation across domains and task types, with an overall success rate of 68.6\%, substantially lower than the 87\% previously reported by OpenAI, demonstrating the utility of our approach for more rigorous and comparable web agent evaluation.
  •  

GISTBench: Evaluating LLM User Understanding via Evidence-Based Interest Verification

arXiv:2603.29112v1 Announce Type: new Abstract: We introduce GISTBench, a benchmark for evaluating Large Language Models' (LLMs) ability to understand users from their interaction histories in recommendation systems. Unlike traditional RecSys benchmarks that focus on item prediction accuracy, our benchmark evaluates how well LLMs can extract and verify user interests from engagement data. We propose two novel metric families: Interest Groundedness (IG), decomposed into precision and recall components to separately penalize hallucinated interest categories and reward coverage, and Interest Specificity (IS), which assesses the distinctiveness of verified LLM-predicted user profiles. We release a synthetic dataset constructed on real user interactions on a global short-form video platform. Our dataset contains both implicit and explicit engagement signals and rich textual descriptions. We validate our dataset fidelity against user surveys, and evaluate eight open-weight LLMs spanning 7B to 120B parameters. Our findings reveal performance bottlenecks in current LLMs, particularly their limited ability to accurately count and attribute engagement signals across heterogeneous interaction types.
  •  

SciVisAgentBench: A Benchmark for Evaluating Scientific Data Analysis and Visualization Agents

arXiv:2603.29139v1 Announce Type: new Abstract: Recent advances in large language models (LLMs) have enabled agentic systems that translate natural language intent into executable scientific visualization (SciVis) tasks. Despite rapid progress, the community lacks a principled and reproducible benchmark for evaluating these emerging SciVis agents in realistic, multi-step analysis settings. We present SciVisAgentBench, a comprehensive and extensible benchmark for evaluating scientific data analysis and visualization agents. Our benchmark is grounded in a structured taxonomy spanning four dimensions: application domain, data type, complexity level, and visualization operation. It currently comprises 108 expert-crafted cases covering diverse SciVis scenarios. To enable reliable assessment, we introduce a multimodal outcome-centric evaluation pipeline that combines LLM-based judging with deterministic evaluators, including image-based metrics, code checkers, rule-based verifiers, and case-specific evaluators. We also conduct a validity study with 12 SciVis experts to examine the agreement between human and LLM judges. Using this framework, we evaluate representative SciVis agents and general-purpose coding agents to establish initial baselines and reveal capability gaps. SciVisAgentBench is designed as a living benchmark to support systematic comparison, diagnose failure modes, and drive progress in agentic SciVis. The benchmark is available at https://scivisagentbench.github.io/.
  •  

REFINE: Real-world Exploration of Interactive Feedback and Student Behaviour

arXiv:2603.29142v1 Announce Type: new Abstract: Formative feedback is central to effective learning, yet providing timely, individualised feedback at scale remains a persistent challenge. While recent work has explored the use of large language models (LLMs) to automate feedback, most existing systems still conceptualise feedback as a static, one-way artifact, offering limited support for interpretation, clarification, or follow-up. In this work, we introduce REFINE, a locally deployable, multi-agent feedback system built on small, open-source LLMs that treats feedback as an interactive process. REFINE combines a pedagogically-grounded feedback generation agent with an LLM-as-a-judge-guided regeneration loop using a human-aligned judge, and a self-reflective tool-calling interactive agent that supports student follow-up questions with context-aware, actionable responses. We evaluate REFINE through controlled experiments and an authentic classroom deployment in an undergraduate computer science course. Automatic evaluations show that judge-guided regeneration significantly improves feedback quality, and that the interactive agent produces efficient, high-quality responses comparable to a state-of-the-art closed-source model. Analysis of real student interactions further reveals distinct engagement patterns and indicates that system-generated feedback systematically steers subsequent student inquiry. Our findings demonstrate the feasibility and effectiveness of multi-agent, tool-augmented feedback systems for scalable, interactive feedback.
  •  

SimMOF: AI agent for Automated MOF Simulations

arXiv:2603.29152v1 Announce Type: new Abstract: Metal-organic frameworks (MOFs) offer a vast design space, and as such, computational simulations play a critical role in predicting their structural and physicochemical properties. However, MOF simulations remain difficult to access because reliable analysis require expert decisions for workflow construction, parameter selection, tool interoperability, and the preparation of computational ready structures. Here, we introduce SimMOF, a large language model based multi agent framework that automates end-to-end MOF simulation workflows from natural language queries. SimMOF translates user requests into dependency aware plans, generates runnable inputs, orchestrates multiple agents to execute simulations, and summarizes results with analysis aligned to the user query. Through representative case studies, we show that SimMOF enables adaptive and cognitively autonomous workflows that reflect the iterative and decision driven behavior of human researchers and as such provides a scalable foundation for data driven MOF research.
  •  

Predicting Neuromodulation Outcome for Parkinson's Disease with Generative Virtual Brain Model

arXiv:2603.29176v1 Announce Type: new Abstract: Parkinson's disease (PD) affects over ten million people worldwide. Although temporal interference (TI) and deep brain stimulation (DBS) are promising therapies, inter-individual variability limits empirical treatment selection, increasing non-negligible surgical risk and cost. Previous explorations either resort to limited statistical biomarkers that are insufficient to characterize variability, or employ AI-driven methods which is prone to overfitting and opacity. We bridge this gap with a pretraining-finetuning framework to predict outcomes directly from resting-state fMRI. Critically, a generative virtual brain foundation model, pretrained on a collective dataset (2707 subjects, 5621 sessions) to capture universal disorder patterns, was finetuned on PD cohorts receiving TI (n=51) or DBS (n=55) to yield individualized virtual brains with high fidelity to empirical functional connectivity (r=0.935). By constructing counterfactual estimations between pathological and healthy neural states within these personalized models, we predicted clinical responses (TI: AUPR=0.853; DBS: AUPR=0.915), substantially outperforming baselines. External and prospective validations (n=14, n=11) highlight the feasibility of clinical translation. Moreover, our framework provides state-dependent regional patterns linked to response, offering hypothesis-generating mechanistic insights.
  •  

AEC-Bench: A Multimodal Benchmark for Agentic Systems in Architecture, Engineering, and Construction

arXiv:2603.29199v1 Announce Type: new Abstract: The AEC-Bench is a multimodal benchmark for evaluating agentic systems on real-world tasks in the Architecture, Engineering, and Construction (AEC) domain. The benchmark covers tasks requiring drawing understanding, cross-sheet reasoning, and construction project-level coordination. This report describes the benchmark motivation, dataset taxonomy, evaluation protocol, and baseline results across several domain-specific foundation model harnesses. We use AEC-Bench to identify consistent tools and harness design techniques that uniformly improve performance across foundation models in their own base harnesses, such as Claude Code and Codex. We openly release our benchmark dataset, agent harness, and evaluation code for full replicability at https://github.com/nomic-ai/aec-bench under an Apache 2 license.
  •  

Route-Induced Density and Stability (RIDE): Controlled Intervention and Mechanism Analysis of Routing-Style Meta Prompts on LLM Internal States

arXiv:2603.29206v1 Announce Type: new Abstract: Routing is widely used to scale large language models, from Mixture-of-Experts gating to multi-model/tool selection. A common belief is that routing to a task ``expert'' activates sparser internal computation and thus yields more certain and stable outputs (the Sparsity--Certainty Hypothesis). We test this belief by injecting routing-style meta prompts as a textual proxy for routing signals in front of frozen instruction-tuned LLMs. We quantify (C1) internal density via activation sparsity, (C2) domain-keyword attention, and (C3) output stability via predictive entropy and semantic variation. On a RouterEval subset with three instruction-tuned models (Qwen3-8B, Llama-3.1-8B-Instruct, and Mistral-7B-Instruct-v0.2), meta prompts consistently densify early/middle-layer representations rather than increasing sparsity; natural-language expert instructions are often stronger than structured tags. Attention responses are heterogeneous: Qwen/Llama reduce keyword attention, while Mistral reinforces it. Finally, the densification--stability link is weak and appears only in Qwen, with near-zero correlations in Llama and Mistral. We present RIDE as a diagnostic probe for calibrating routing design and uncertainty estimation.
  •  

Xuanwu: Evolving General Multimodal Models into an Industrial-Grade Foundation for Content Ecosystems

arXiv:2603.29211v1 Announce Type: new Abstract: In recent years, multimodal large models have continued to improve on general benchmarks. However, in real-world content moderation and adversarial settings, mainstream models still suffer from degraded generalization and catastrophic forgetting because of limited fine-grained visual perception and insufficient modeling of long-tail noise. In this paper, we present Xuanwu VL-2B as a case study of how general multimodal models can be developed into an industrial-grade foundation model for content ecosystems. The model adopts a compact InternViT-300M + MLP + Qwen3 1.7B architecture, balancing fine-grained visual perception, language-semantic alignment, and deployment cost within an approximately 2B-parameter budget. To balance business specialization with the retention of general capabilities, we developed a data iteration and curation mechanism and trained the model through a progressive three-stage pipeline: pre-training, mid-training, and post-training. Ablation studies and offline business evaluations show that Xuanwu VL-2B achieves an average score of 67.90 across seven OpenCompass multimodal metrics (vs. 64.27 for InternVL 3.5 2B), an average recall of 94.38% over seven independent business moderation tasks, and a weighted overall recall of 82.82% on policy-violating text in challenging adversarial OCR scenarios, outperforming Gemini-2.5-Pro (76.72%). These results show that, under a limited parameter budget, Xuanwu VL-2B achieves a practical balance among business alignment, visual perception, general capability retention, and deployment cost.
  •  

Beyond pass@1: A Reliability Science Framework for Long-Horizon LLM Agents

arXiv:2603.29231v1 Announce Type: new Abstract: Existing benchmarks measure capability -- whether a model succeeds on a single attempt -- but production deployments require reliability -- consistent success across repeated attempts on tasks of varying duration. We show these properties diverge systematically as task duration grows, and that pass@1 on short tasks is structurally blind to this divergence. We introduce a reliability science framework for long-horizon LLM agents with four metrics: Reliability Decay Curve (RDC), Variance Amplification Factor (VAF), Graceful Degradation Score (GDS), and Meltdown Onset Point (MOP). We evaluate 10 models across 23,392 episodes on a 396-task benchmark spanning four duration buckets and three domains. Key findings: (1) reliability decay is domain-stratified -- SE GDS drops from 0.90 to 0.44 while document processing is nearly flat (0.74 to 0.71); (2) VAF bifurcates by capability tier -- high VAF is a capability signature, not an instability signal; (3) capability and reliability rankings diverge substantially, with multi-rank inversions at long horizons; (4) frontier models have the highest meltdown rates (up to 19%) because they attempt ambitious multi-step strategies that sometimes spiral; and (5) memory scaffolds universally hurt long-horizon performance across all 10 models. These results motivate reliability as a first-class evaluation dimension alongside capability.
  •  

Grokking From Abstraction to Intelligence

arXiv:2603.29262v1 Announce Type: new Abstract: Grokking in modular arithmetic has established itself as the quintessential fruit fly experiment, serving as a critical domain for investigating the mechanistic origins of model generalization. Despite its significance, existing research remains narrowly focused on specific local circuits or optimization tuning, largely overlooking the global structural evolution that fundamentally drives this phenomenon. We propose that grokking originates from a spontaneous simplification of internal model structures governed by the principle of parsimony. We integrate causal, spectral, and algorithmic complexity measures alongside Singular Learning Theory to reveal that the transition from memorization to generalization corresponds to the physical collapse of redundant manifolds and deep information compression, offering a novel perspective for understanding the mechanisms of model overfitting and generalization.
  •  

Nomad: Autonomous Exploration and Discovery

arXiv:2603.29353v1 Announce Type: new Abstract: We introduce Nomad, a system for autonomous data exploration and insight discovery. Given a corpus of documents, databases, or other data sources, users rarely know the full set of questions, hypotheses, or connections that could be explored. As a result, query-driven question answering and prompt-driven deep-research systems remain limited by human framing and often fail to cover the broader insight space. Nomad addresses this problem with an exploration-first architecture. It constructs an explicit Exploration Map over the domain and systematically traverses it to balance breadth and depth. It generates and selects hypotheses and investigates them with an explorer agent that can use document search, web search, and database tools. Candidate insights are then checked by an independent verifier before entering a reporting pipeline that produces cited reports and higher-level meta-reports. We also present a comprehensive evaluation framework for autonomous discovery systems that measures trustworthiness, report quality, and diversity. Using a corpus of selected UN and WHO reports, we show that \nomad{} produces more trustworthy and higher-quality reports than baselines, while also producing more diverse insights over several runs. Nomad is a step toward autonomous systems that not only answer user questions or conduct directed research, but also discover which questions, research directions, and insights are worth surfacing in the first place.
  •  

BenchScope: How Many Independent Signals Does Your Benchmark Provide?

arXiv:2603.29357v1 Announce Type: new Abstract: AI evaluation suites often report many scores without checking whether those scores carry independent information. We introduce Effective Dimensionality (ED), the participation ratio of a centered benchmark-score spectrum, as a fast, population-conditional upper-bound diagnostic of measurement breadth. Applied at per-instance granularity to 22 benchmarks across 8 domains and more than 8,400 model evaluations, ED reveals substantial redundancy: the six-score Open LLM Leaderboard behaves like roughly two effective measurement axes (ED = 1.7), BBH and MMLU-Pro are near-interchangeable (rho = 0.96, stable across seven subpopulations), and measurement breadth varies more than 20x across current benchmarks. We show that relative ED rankings are stable under matched-dimension controls and that ED can flag redundant suite components, monitor performance-conditional compression, and guide benchmark maintenance. Because binary spectra overestimate absolute latent dimensionality, we interpret ED as a screening statistic rather than a literal factor count and complement it with null, reliability, and saturation analyses. We provide a 22-benchmark reference atlas and a four-step diagnostic workflow that benchmark maintainers can run with a score matrix and a few lines of code.
  •  

Structural Compactness as a Complementary Criterion for Explanation Quality

arXiv:2603.29491v1 Announce Type: new Abstract: In the evaluation of attribution quality, the quantitative assessment of explanation legibility is particularly difficult, as it is influenced by varying shapes and internal organization of attributions not captured by simple statistics. To address this issue, we introduce Minimum Spanning Tree Compactness (MST-C), a graph-based structural metric that captures higher-order geometric properties of attributions, such as spread and cohesion. These components are combined into a single score that evaluates compactness, favoring attributions with salient points spread across a small area and spatially organized into few but cohesive clusters. We show that MST-C reliably distinguishes between explanation methods, exposes fundamental structural differences between models, and provides a robust, self-contained diagnostic for explanation compactness that complements existing notions of attribution complexity.
  •  

Learning to Generate Formally Verifiable Step-by-Step Logic Reasoning via Structured Formal Intermediaries

arXiv:2603.29500v1 Announce Type: new Abstract: Large language models (LLMs) have recently demonstrated impressive performance on complex, multi-step reasoning tasks, especially when post-trained with outcome-rewarded reinforcement learning Guo et al. 2025. However, it has been observed that outcome rewards often overlook flawed intermediate steps, leading to unreliable reasoning steps even when final answers are correct. To address this unreliable reasoning, we propose PRoSFI (Process Reward over Structured Formal Intermediates), a novel reward method that enhances reasoning reliability without compromising accuracy. Instead of generating formal proofs directly, which is rarely accomplishable for a modest-sized (7B) model, the model outputs structured intermediate steps aligned with its natural language reasoning. Each step is then verified by a formal prover. Only fully validated reasoning chains receive high rewards. The integration of formal verification guides the model towards generating step-by-step machine-checkable proofs, thereby yielding more credible final answers. PRoSFI offers a simple and effective approach to training trustworthy reasoning models.
  •  
❌