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Functional RNA splitting drove the evolutionary emergence of type V CRISPR-Cas systems from transposons
(Cell 188, 6283β6300.e1βe10; October 30, 2025)
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Efficient amyloid-Ξ² degradation in Alzheimerβs disease using SPYTACs
SPYTAC is a synthetic peptide-programmed targeted protein degradation platform harnessing LRP1 to drive lysosomal degradation of extracellular amyloid-Ξ² in the brain and periphery. In 5ΓFAD mice, SPYTAC treatment efficiently degrades amyloid-Ξ², preserves neurons, and improves cognition with reduced neuroinflammation and microhemorrhage when compared with antibody therapy.
