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CausalFlow: Causal Attribution and Counterfactual Repair for LLM Agent Failures

arXiv:2605.25338v1 Announce Type: cross Abstract: Large language model (LLM) agents frequently fail on multi-step tasks involving reasoning, tool use, and environment interaction. While such failures are typically logged or retried heuristically, they contain structured signals about where execution broke down. We introduce CausalFlow, an interventional framework that converts failed agent traces into minimal counterfactual repairs and reusable supervision. CausalFlow models execution traces as sequential chains of dependent steps and computes Causal Responsibility Scores(CRS) via step-level counterfactual intervention to identify failure-inducing steps. For these steps, we generate minimally edited repairs that flip the final outcome to success, producing validated contrastive pairs of the form (wrong step, corrected step). CausalFlow supports two complementary uses: targeted test-time repair that recovers from failures with minimal behavioral drift, and training-time supervision suitable for offline preference optimization or reward modeling. Across four benchmarks spanning mathematical reasoning, code generation, question answering, and medical browsing, CausalFlow converts failed executions into validated minimal repairs with high minimality and causal-consensus scores, and demonstrates that causal attribution is necessary for reliable improvement across diverse agent tasks, outperforming heuristic refinement in complex retrieval settings while producing more localized repairs throughout. These results demonstrate that interventional analysis over structured execution traces provides a principled and scalable mechanism for transforming agent failures into reliability gains and learning-ready supervision.
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De novo design of quasisymmetric two-component protein cages

Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10464-0

Researchers designed two-component proteins forming quasisymmetric cages via geometric frustration, enabling tunable virus-like assemblies for cargo delivery, cellular uptake and studying intracellular diffusion and protein localization.
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Editorial Expression of Concern: Disruption of transforming growth factor-<i>β</i> signaling through <i>β</i>-spectrin ELF leads to hepatocellular cancer through cyclin D1 activation

Oncogene, Published online: 11 May 2026; doi:10.1038/s41388-026-03821-w

Editorial Expression of Concern: Disruption of transforming growth factor-β signaling through β-spectrin ELF leads to hepatocellular cancer through cyclin D1 activation
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Correction to: Targeting Lyn regulates Snail family shuttling and inhibits metastasis

Oncogene, Published online: 15 April 2026; doi:10.1038/s41388-026-03789-7

Correction to: Targeting Lyn regulates Snail family shuttling and inhibits metastasis
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