Transduction efficiency is a critical determinant of CAR T-cell manufacturing quality. Analysis of 204 clinical CAR T-cell products revealed that transduction efficiency is shaped primarily by manufacturing workflows and protocol-dependent starting material composition. Higher transduction efficiency was associated with early memory-like cellular states, providing insights into optimizing CAR T-cell.

This study developed a multi-layer inducible RNA switch that achieves transient expression of gene-delivery vectors in hepatic and non-hepatic tissues. As an exemplary application, this RNA switch triggers pulsive expression of gene editors that reduces the off-target effects and immunotoxicity of gene editing.

Nature Biomedical Engineering, Published online: 07 September 2026; doi:10.1038/s41551-026-01794-5

Author Correction: A base editor for the long-term restoration of auditory function in mice with recessive profound deafness

arXiv:2609.09578v1 Announce Type: new Abstract: Urban planning is a real-world spatial optimization problem that requires selecting feasible actions from large candidate spaces under practical objectives such as cost and service quality. Existing optimization and reinforcement learning methods are effective for fixed formulations, but often depend on task-specific representations and constraint handling. We propose \emph{CityPlanner}, a sandbox-agent framework for executable urban planning. CityPlanner introduces \emph{UrbanSandbox}, a unified file-based environment where agents inspect task files, generate plans, run evaluators, and revise decisions based on executable feedback. To make learning tractable, we further propose atomic-task reinforcement learning, which decomposes long sandbox trajectories into \emph{BuildPlan} for initial construction and \emph{ImprovePlan} for feedback-based refinement. Experiments on a real-world benchmark show that CityPlanner consistently outperforms heuristic, task-specific RL, and general LLM-agent baselines. Ablations verify the contributions of UrbanSandbox, atomic-task RL, and iterative deployment. We release the code and dataset at https://anonymous.4open.science/r/co-agent-C1C8

arXiv:2608.30935v2 Announce Type: replace-cross Abstract: Embodied navigation requires agents to translate heterogeneous goals and visual observations into actions across tasks, environments, and robot embodiments. Modern vision-language models (VLMs) already encode spatial priors for visual grounding, spatial reasoning, and pointing, but these capabilities are rarely elicited directly for robot control. Existing navigation systems instead rely on task- or embodiment-specific components, fragmenting perception, reasoning, and action while offering limited generalization. Here we present LightNav-0, a compact generalist embodied navigation model that elicits the spatial intelligence of a pretrained VLM and aligns it with navigation, without task-specific prediction heads. LightNav-0 represents diverse navigation tasks through a unified token interface: dual-channel pointing expresses task-, scene-, and embodiment-agnostic spatial intent, while a residual vector-quantized action tokenizer maps this intent to precise, embodiment-specific trajectories. Together with temporally aware visual history compression, ER mid-training, supervised fine-tuning, and reinforcement learning, this formulation supports instruction following, open-vocabulary object navigation, and visual tracking within a single model. The navigation training corpus spans 2K+ scenes and 4K+ hours of embodied navigation data. LightNav-ER, the embodied-reasoning checkpoint used to initialize LightNav-0, attains the highest complete-set average across 8 embodied-reasoning benchmarks, while LightNav-0 achieves state-of-the-art monocular success rates across all 10 public navigation simulation settings. Real-world evaluations further demonstrate zero-shot generalization across robot embodiments, diverse scenes, and static and dynamic targets. These results establish compact VLMs as a unified and transferable backbone for generalist embodied navigation.

arXiv:2609.04867v2 Announce Type: replace-cross Abstract: Text-to-audio-video (T2AV) generation has advanced rapidly, but its evaluation still underestimates the audio modality. Existing benchmarks either treat audio as an auxiliary component of video quality or assess it in isolation from audiovisual grounding, making it difficult to diagnose where current systems truly succeed or fail in audio generation. We present PRISM-Bench, the first audio-centric diagnostic benchmark for T2AV generation. Built from a rigorously curated dataset of 900 human-verified samples, PRISM-Bench factorizes audio evaluation along two orthogonal axes: audio type (Speech, Music, and Sound) and sound-source visibility (On-screen vs. Off-screen). It evaluates generated content across four perceptual dimensions (Audio-Visual Coherence, Audio Quality, Audio Expressiveness, and Prompt Following) with 35 fine-grained criteria. To ensure reliable assessment, we adopt an enhanced MLLM-as-a-Judge protocol based on blind, side-by-side comparison against ground-truth references, demonstrating strong alignment (over 70% mean agreement) with human raters. Our evaluation of recent T2AV systems highlights a significant performance gap between frontier and open-source models. Furthermore, we demonstrate that current generation paradigms overfit to perceptual fidelity while struggling with complex grounding and control tasks, particularly in generating music and synchronized On-screen audio.