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DGCPath: Distribution-Aware Generative Contrastive Framework for Self-supervised Path Representation Learning -- Extended Version

arXiv:2609.07316v2 Announce Type: replace Abstract: Due to the proliferation of vehicle trajectory data enabled by advanced sensing technologies, path representation learning has become a pivotal task in intelligent transportation systems. Although existing self-supervised approaches have achieved promising performance, their dependence on deterministic contrastive learning paradigms and handcrafted view augmentation strategies inherently restricts their cross-scenario generalization capabilities. To address these limitations, we present DGCPath, an innovative Distribution-aware Generative Contrastive learning framework for Path representation. This framework establishes a synergistic connection between generative modeling and distributional contrastive learning, enabling the acquisition of robust and transferable feature embeddings. Specifically, our framework incorporates: (1) a diffusion-based view generator that autonomously produces semantically coherent yet diverse trajectory views from Gaussian noise; (2) a variational contrastive mechanism that enforces latent feature alignment at the distribution level, transcending conventional instance-wise consistency; and (3) a novel generative cross-supervision module that reinforces view-level consistency through cross-view reconstruction learning. Comprehensive evaluations on three real-world trajectory datasets demonstrate that DGCPath outperforms state-of-the-art baselines on two distinct downstream tasks, validating its enhanced generalization capability and representation effectiveness.
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DHCR24<sup>+</sup> tumor epithelial cells drive cisplatin resistance in bladder cancer by enhancing cholesterol metabolism to activate lipid raft-associated MAPK signaling

Oncogene, Published online: 29 August 2026; doi:10.1038/s41388-026-03967-7

DHCR24+ tumor epithelial cells drive cisplatin resistance in bladder cancer by enhancing cholesterol metabolism to activate lipid raft-associated MAPK signaling
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Complete biosynthesis of the anticancer cephalotaxinone and homoerythratine

Complete biosynthetic pathways for cephalotaxinone and homoerythratine were elucidated from the endangered plant Cephalotaxus fortunei. Thirteen key enzymes were identified, including two homologous cytochrome P450 enzymes that catalyze a rare divergent oxidation process governing alkaloid scaffold diversification. Full pathway reconstitution in Nicotiana benthamiana establishes a foundation for the sustainable production of the anticancer agent homoharringtonine.
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