A vasoactive intestinal peptide (VIP)-based protein carrier self-assembles with respiratory syncytial virus circular RNA vaccines for intranasal delivery, inducing systemic antibodies, mucosal IgA, and Th1-biased protection in mice. This platform offers a protein-guided strategy for respiratory mucosal RNA vaccination and broadens the application of VIP in vaccine delivery.

arXiv:2609.10177v1 Announce Type: new Abstract: In-context learning (ICL) is widely used in multimodal large language models (MLLMs) and achieves strong performance across a wide range of multimodal tasks. However, existing multimodal ICL methods often rely on surface level imitation of in-context demonstrations, making it difficult for MLLMs to align their responses with the reasoning path required by the given multimodal input. This limitation becomes more pronounced in complex multimodal tasks, thereby restricting further improvements in MLLM performance. To address this issue, we propose a new multimodal ICL framework that combines contrastive demonstration modeling with the self-refinement capability of MLLMs. Specifically, our framework reformulates each demonstration by explicitly contrasting a suboptimal response with a better response under the same input, together with a reasoning path that reveals how the response should be refined. This contrastive formulation makes the reasoning path toward the desired response more explicit and guides the MLLM beyond superficial imitation. Furthermore, because effective refinement depends on the current response, we introduce a response-conditioned retrieval mechanism to select demonstrations whose reasoning paths are more relevant to the current response. In addition, we use a lightweight alignment controller to predict response quality and determine whether further refinement is needed. Experiments on three types of multimodal tasks show that the proposed framework consistently improves MLLM performance, with particularly notable gains on visual question answering (VQA).

arXiv:2609.10108v1 Announce Type: cross Abstract: Aging clocks quantify biological aging and help characterize individual health status. What protein interactions are important for accurate aging clocks, and are they zeroth-order or higher-order? Addressing these questions requires learning from large molecular datasets distributed across medical centers, where privacy constraints prevent centralized data sharing. Federated learning offers a natural solution but faces four challenges in this setting: limited local sample sizes, sparse and directional inter-center trust, the need to retain discriminative age prediction while supporting interpretation, and model drift and forgetting under heterogeneous cross-center data. We propose TNFL, a trust-network-based federated learning framework that progressively propagates models along directed pairwise trust relations without centralized aggregation. TNFL combines an age-aware mixture-of-experts model with generative replay to preserve previously learned information and reduce forgetting and drift. Experiments across multiple molecular datasets show that TNFL enables effective aging-clock prediction with limited local data, provides interpretable age-dependent prediction patterns, and maintains stable performance across interaction orders. To investigate the biological questions, we analyze TNFL-identified pairwise protein interactions and their higher-order organization through functional and network analyses. The identified interactions repeatedly form coordinated higher-order subnetworks spanning multiple aging-related biological systems, with several proteins recurring across subnetworks. These findings suggest that TNFL captures molecular relationships beyond isolated pairwise associations and reveals coherent higher-order biological organization associated with aging.

arXiv:2606.08653v2 Announce Type: replace-cross Abstract: Action-supervised fine-tuning of vision-language-action (VLA) policies fits demonstrations effectively but constrains only the directions that change predicted actions, leaving visual structure consistent across action-equivalent states free to collapse. We formalize this as residual visual collapse along local action fibers and propose FiberTune, a training-time objective that preserves teacher-structured visual residuals without adding inference-time overhead. FiberTune uses an online action probe to estimate action-predictive feature directions, filters them from intermediate visual-token representations, and aligns the resulting probe-filtered residuals to a frozen visual teacher while regularizing their effective rank. Under identical training conditions, FiberTune improves over task-loss-only fine-tuning in every one of six controlled simulation settings spanning two benchmarks and two architectures (pi_0.5 and OpenVLA-OFT), as well as on physical SO-101 pick-place; representative gains include +10.7 percentage points SR(5) on long-horizon CALVIN ABC-to-D and physical SO-101 task success rising from 72.7% to 78.1%. Residual diagnostics show that these gains coincide with increased probe-filtered residual teacher alignment and effective rank, consistent with the action-fiber motivation.