MNK1 acts as a structural shield on MYH9, preventing YAP1-mediated platelet activation. Developing MD2 to lock this MNK1-MYH9 complex introduces a safe antithrombotic strategy, shifting the therapeutic paradigm from kinase inhibition to stabilizing protein-protein interactions against immunothrombosis.

Nature, Published online: 07 September 2026; doi:10.1038/s41586-026-11094-2

Author Correction: A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution