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Multi-Agent Agentic Graph Learning via Structural Signatures

arXiv:2609.09565v1 Announce Type: new Abstract: Agentic graph learning (AGL) has recently achieved promising results on graph reasoning tasks, where an agent powered by a large language model (LLM) sequentially samples the graph as evidence to support its final prediction. Existing methods either employ a single agent or orchestrate multiple role-based agents to reason and learn over the entire graph, but both essentially rely on a shared reasoning policy across different graph regions, which can be suboptimal for graphs with heterogeneous structural and semantic patterns. Inspired by the progress of multi-agent collaboration on complex reasoning tasks, a natural remedy is to let multiple agents own different memory and collaborate; however, applying this paradigm to graphs directly faces two challenges. First, existing AGL methods typically verbalize graph structures into natural-language descriptions for LLM agents, making the reasoning process sensitive to the ordering of structural information and thereby breaking the permutation-invariant nature of graphs. Second, incorporating increasingly large sampled neighborhoods leads to rapidly growing contexts. To address these challenges, this paper introduces a multi-agent agentic graph learning (i.e., MAAGL) framework. MAAGL partitions the graph into communities and assigns an independent agent to each community for region-specific specialization. MAAGL represents structural and semantic evidence separately. Structural evidence is summarized by a dynamically updated structural signature that is permutation-invariant and fixed in size, while semantic evidence is filtered to the top-k nodes ranked by relevance. Based on historical trajectories with similar signatures, agents estimate their confidence and trigger debate-style collaboration when needed. Extensive experiments on four benchmark datasets show that MAAGL outperforms SOTA AGL methods.
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Commensal <i>Nakaseomyces glabratus</i> migrates into prostate tumors to accelerate cancer progression

Nature Cancer, Published online: 09 September 2026; doi:10.1038/s43018-026-01229-9

Lai et al. show that Nakaseomyces glabratus is enriched in fecal and tumor samples of patients with castration-resistant prostate cancer and that administration of the fungus accelerates cancer progression in prostate cancer-bearing castrated mice.
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Lipotoxicity-induced ER-mitochondrial hypercoupling activates the mtDNA-cGAS-STING-NF-κB axis to drive follicular arrest in metabolically compromised PCOS

Cell Death Discovery, Published online: 08 September 2026; doi:10.1038/s41420-026-03339-w

Lipotoxicity-induced ER-mitochondrial hypercoupling activates the mtDNA-cGAS-STING-NF-κB axis to drive follicular arrest in metabolically compromised PCOS
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