MNK1 acts as a structural shield on MYH9, preventing YAP1-mediated platelet activation. Developing MD2 to lock this MNK1-MYH9 complex introduces a safe antithrombotic strategy, shifting the therapeutic paradigm from kinase inhibition to stabilizing protein-protein interactions against immunothrombosis.

Latent HIV reservoirs evade both antiviral therapy and immune surveillance. Luo and colleagues develop a multifunctional fusion protein that couples reservoir reactivation with targeted immune engagement and clearance, offering a coordinated strategy to expose and eliminate persistent HIV-infected cells.

Nature Biomedical Engineering, Published online: 31 August 2026; doi:10.1038/s41551-026-01782-9

A protein engineering strategy enables nitric oxide-triggered reactivation of proteins using genetically encoded caged amino acids, allowing inflammation-localized control of protein activity, viral gene delivery and biosensing in vivo.

arXiv:2609.09928v1 Announce Type: new Abstract: Latent reasoning approaches enhance token-level efficiency and robustness by replacing verbose, explicit chain-of-thought (CoT) tokens with compact continuous-space embeddings. However, existing methods lack direct process supervision over these latent embeddings, which often leads to representation collapse and uneven information distribution. To address this, we propose Prototype-Mediated Process Supervision (PMPS), which introduces learnable reasoning prototypes as semantic anchors to provide structural process-level supervision for latent reasoning. PMPS projects latent embeddings and explicit CoT embeddings into a shared prototype space, achieving many-to-many soft alignment between unequal-length representations through prototype assignment. Meanwhile, we introduce a Progressive Sequential Alignment (PSA) module to further guide training: positional priors initially encourage sequential alignment structure, then gradually relax to permit adaptive matching. Experimental results show that PMPS compresses output token length to under 50% of explicit CoT on GSM8K-Aug. Compared to leading baseline SIM-CoT, our method achieves average accuracy gains of 2.08% across different model families. On GPT-2, PMPS even surpasses CoT-SFT. On larger models and a more challenging task, PMPS consistently attains the highest accuracy among all latent reasoning methods with comparable output length.

arXiv:2609.09396v1 Announce Type: cross Abstract: As Vision-Language Models (VLMs) advance toward physical deployment, the focus has remained on action-oriented Embodied AI evaluated on subject-centric consumer video. This overlooks a pervasive class of Physical AI: Infrastructure AI, which relies on fixed cameras for open-loop insights like safety monitoring and operational logging. We introduce VANTAGE-Bench, a benchmark measuring this "Infrastructure AI Gap." It spans three operational domains (Logistics, Transportation, and Smart Spaces), unifies image and video evaluation across semantic, spatial, temporal, and spatio-temporal capabilities, and moves beyond multiple-choice to eight task formulations including dense captioning and spatio-temporal grounding. It adds a single-pass trajectory protocol for Single Object Tracking and, to our knowledge, the first such evaluation on fixed-camera infrastructure video, scored against specialist trackers. Annotation spans three regimes over 3,346 media assets: 3,342 video-task annotations, 4,281 image-grounding annotations, and 27,404 detection boxes. Evaluating 17 models zero-shot, we find the shortfall relative to consumer-centric benchmarks is concentrated, not general. Event verification, referring expressions, and temporal localization fall roughly 9 to 24 points at every model scale, while video question answering stays within 5.3 points of VideoMME and 2D spatial pointing shows no shortfall against BLINK. The temporal pillar is weakest in absolute terms: no system exceeds 55.7 mIoU on temporal localization or 37.3 SODA_c on dense video captioning. On tracking, frontier models come within roughly 5 points of specialist trackers over short horizons but separate as the horizon extends. Open-weight models lead 2D object localization outright, so neither scale nor proprietary access explains the pattern. Data, evaluation harness, and leaderboard: https://vantage-bench.org/

arXiv:2608.24979v2 Announce Type: replace Abstract: Scientific agents increasingly analyze data, execute code, and produce research artifacts, yet most benchmarks emphasize final answers, isolated programs, or a single domain. We introduce FrontierChallenge, a cross-domain benchmark comprising 300 end-to-end scientific workflows. In this paper, we release and evaluate 97 of these tasks, spanning quantum chemistry, molecular dynamics, materials characterization, analytical chemistry, life science, and electrochemistry/environment. Each task provides fixed inputs and specifies a bundle of required scientific deliverables. We evaluate twelve frontier models with three agent scaffolds. Pass Rate measures the fraction of tasks satisfying the full-completion criterion, while Avg. Score captures partial progress. Each of the best-performing configurations completed only 20 of the 97 released tasks, yielding a Pass Rate of 20.6%. Partial progress translated especially poorly into complete delivery in analytical chemistry and electrochemistry/environment: Avg. Scores reached 87.6 and 94.9, but the highest Pass Rates were only 4% and 0%. Among non-passing Claude Code trajectories, 75.5% still ended with language claiming completion. Complementary HDS6 process scores correlate strongly with task outcomes, supporting FrontierChallenge as a benchmark of Heavy Duty Solver capabilities. These findings show that neither high partial scores nor confident claims of completion reliably indicate that a scientific task has been fully delivered, highlighting the need to evaluate end-to-end workflow execution and the completeness of scientific deliverables together.

arXiv:2608.30935v2 Announce Type: replace-cross Abstract: Embodied navigation requires agents to translate heterogeneous goals and visual observations into actions across tasks, environments, and robot embodiments. Modern vision-language models (VLMs) already encode spatial priors for visual grounding, spatial reasoning, and pointing, but these capabilities are rarely elicited directly for robot control. Existing navigation systems instead rely on task- or embodiment-specific components, fragmenting perception, reasoning, and action while offering limited generalization. Here we present LightNav-0, a compact generalist embodied navigation model that elicits the spatial intelligence of a pretrained VLM and aligns it with navigation, without task-specific prediction heads. LightNav-0 represents diverse navigation tasks through a unified token interface: dual-channel pointing expresses task-, scene-, and embodiment-agnostic spatial intent, while a residual vector-quantized action tokenizer maps this intent to precise, embodiment-specific trajectories. Together with temporally aware visual history compression, ER mid-training, supervised fine-tuning, and reinforcement learning, this formulation supports instruction following, open-vocabulary object navigation, and visual tracking within a single model. The navigation training corpus spans 2K+ scenes and 4K+ hours of embodied navigation data. LightNav-ER, the embodied-reasoning checkpoint used to initialize LightNav-0, attains the highest complete-set average across 8 embodied-reasoning benchmarks, while LightNav-0 achieves state-of-the-art monocular success rates across all 10 public navigation simulation settings. Real-world evaluations further demonstrate zero-shot generalization across robot embodiments, diverse scenes, and static and dynamic targets. These results establish compact VLMs as a unified and transferable backbone for generalist embodied navigation.