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A Human Audit of OpenAIs AI-Generated Mathematical Proofs
AtlasNLP: A Country-Aware Atlas of Dataset Representation in NLP
PLA2G2D in tumour-draining lymph nodes regulates anti-tumour immunity
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10954-1
A specific population of macrophages that express high levels of the enzyme PLA2G2D in tumour-draining lymph nodes is associated with poor prognosis in patients, and inhibiting PLA2G2D improves anti-tumour immunity in mouse models.Foaming photopolymers as a high-resolution biomimetic printing platform
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10968-9
Deep-foam photolithography uses light-controlled polymer foaming to create high-resolution, multifunctional microstructures with tunable optical, wetting and fluid-handling properties for advanced manufacturing applications.Advancing conflict research and response through satellite-derived data
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11004-6
Integrating satellite-derived war-damage data with text-based fatality records through improvement, enrichment and fusion mitigates limitations inherent in each source, revealing complex violence dynamics beyond fatality-centric paradigms, as case studies from Ukraine and Myanmar illustrate.Imaging cellular activity across all organs reveals body-wide circuits
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10979-6
An imaging system developed to record cellular activity throughout the whole body of zebrafish captures cellular organ dynamics and identifies multiple distributed circuits.Proximity-guided graph learning reveals tumour-associated proximity antigens
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11003-7
A proximity-mapping atlas defines tumour-associated proximity antigens, revealing disease-associated membrane spatial communities, and identifies EGFR–CDCP1 as a co-target pair that enhances tumour killing by multispecific therapeutics.Integration of proteomic aging clocks in a phase 2a clinical trial supports simultaneous geroprotective assessment
Nature Biotechnology, Published online: 07 September 2026; doi:10.1038/s41587-026-03286-y
Six proteomic clocks are applied in a clinical trial to assess anti-aging effects.Arrest of human spermatogenesis at the pachytene stage is frequently accompanied by disruption of the piRNA pathway
Cell Death Discovery, Published online: 03 September 2026; doi:10.1038/s41420-026-03327-0
Arrest of human spermatogenesis at the pachytene stage is frequently accompanied by disruption of the piRNA pathwayTranscriptomic profiling reveals complement activation in chronic pancreatitis adjacent to pancreatic ductal adenocarcinoma
Immunobiology. 2026 Aug 28;231(5):153239. doi: 10.1016/j.imbio.2026.153239. Online ahead of print.
ABSTRACT
Chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC) frequently coexist, yet distinguishing inflammatory changes secondary to malignancy from primary pancreatitis remains challenging. Here, we present an integrated multi-omics analysis of spatially distinct pancreatic tissue compartments obtained from a single patient undergoing pancreaticoduodenectomy for PDAC, combining histopathology, transcriptomics, immunofluorescence, and meta-transcriptomic microbial profiling. Morphological assessment identified tumor tissue, adjacent CP, and normal pancreas. Transcriptomic profiling of macro-dissected samples revealed differential gene expression and enrichment of the classical complement pathway in the CP compartment, which was qualitatively supported by immunofluorescent detection of C1q and C3 along the ductal epithelium. Meta-transcriptomic analysis detected a limited number of bacterial taxa and no viral RNA; these findings were interpreted conservatively given the constraints of low-biomass tissue profiling and the single-patient design. Although causal inference and generalizability are limited by the single-patient design, this study demonstrates the feasibility of integrating pathology with transcriptomic and microbial analyses to generate a hypothesis-generating, multi-omics framework for exploring inflammatory-malignant interactions in pancreatic disease.
PMID:42679433 | DOI:10.1016/j.imbio.2026.153239