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Liver-specific <i>SIRT1</i> knockout-induced hyperglycemia promotes spontaneous lung adenocarcinomas through HSF1-MDM2

Oncogene, Published online: 24 May 2026; doi:10.1038/s41388-026-03826-5

Liver-specific SIRT1 knockout-induced hyperglycemia promotes spontaneous lung adenocarcinomas through HSF1-MDM2

Mapping convergent regulators of melanoma drug resistance by PerturbFate

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10367-0

PerturbFate is a high-throughput, cost-effective, single-cell platform that systematically profiles CRISPR interference perturbations to reveal common regulatory nodes and convergent phenotypic states across diverse genetic alterations linked to vemurafenib resistance in melanoma cells.

The importance of competition and facilitation for global tree diversity

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10349-2

Across 17 forest plots (2.7 million trees, 5,400 species), competition dominated overall, but facilitation was relatively stronger near the equator and declined towards higher latitudes, partly linked to temperature, legumes, mycorrhizal associations and canopy nursing effect.
  • ✇Nature Cancer
  • A functional map of m<sup>6</sup>A sites in cancer Yalong Wang · Han Xu
    Nature Cancer, Published online: 13 March 2026; doi:10.1038/s43018-026-01137-yRNA N6-methyladenosine (m6A) is the most abundant internal RNA modification, yet its functional landscape in cancer remains poorly defined. A study now introduces a METTL3-based RNA base-editing screen that maps functional m6A sites and reveals m6A-dependent translational activation of the tumor suppressor CHD9 in prostate cancer and beyond.
     

A functional map of m<sup>6</sup>A sites in cancer

13 March 2026 at 08:00

Nature Cancer, Published online: 13 March 2026; doi:10.1038/s43018-026-01137-y

RNA N6-methyladenosine (m6A) is the most abundant internal RNA modification, yet its functional landscape in cancer remains poorly defined. A study now introduces a METTL3-based RNA base-editing screen that maps functional m6A sites and reveals m6A-dependent translational activation of the tumor suppressor CHD9 in prostate cancer and beyond.
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