Oncogene, Published online: 04 October 2026; doi:10.1038/s41388-026-04002-5
KDM4A drives TGCT metastasis by inducing focal adhesion disassembly via STAT1-mediated CCL3 transcriptional activation
Oncogene, Published online: 02 October 2026; doi:10.1038/s41388-026-03990-8
Colorectal cancer is often treated with oxaliplatin, but many tumors become less responsive over time, making treatment harder. This study aimed to understand one way cancer cells escape oxaliplatin and to identify a possible way to restore drug response. The researchers studied colorectal cancer cells, drug-resistant cells, mouse tumor models, and tumor-like structures grown from patient samples. They found that oxaliplatin stress lowers a mitochondrial protein called TFAM. This allows mitochondrial DNA to leak into the cell fluid and switch on a survival signal involving TBK1. This signal helps cancer cells clear damaged cell parts and survive treatment. Blocking TBK1 reduced this protective response and made resistant tumors more sensitive to oxaliplatin. These findings suggest that combining oxaliplatin with a TBK1-blocking treatment may help overcome drug resistance in colorectal cancer in the future.
Oncogene, Published online: 01 October 2026; doi:10.1038/s41388-026-04001-6
Nuclear cathepsin L induces DNA damage by regulating DNA repair factors in ovarian cancer
Oncogene, Published online: 30 September 2026; doi:10.1038/s41388-026-03995-3
ACTB promotes ESCC progression by regulating the AKT–mTOR signaling pathway through an m6A-dependent mechanism
Oncogene, Published online: 28 September 2026; doi:10.1038/s41388-026-03996-2
SPTLC2-driven sphingolipid reprogramming of neutrophils impairs anti-tumour immunity and drives liver cancer progression
Oncogene, Published online: 27 September 2026; doi:10.1038/s41388-026-03930-6
Metabolites and cancer metastasis
Oncogene, Published online: 25 September 2026; doi:10.1038/s41388-026-03992-6
A positive feedback loop between YTHDC1 and EP300 drives multiple myeloma tumorigenesis
Oncogene, Published online: 25 September 2026; doi:10.1038/s41388-026-03998-0
KIFC1 engages RUNX2/TGF-β signaling to promote lung cancer bone metastasis via disrupting bone homeostasis
Oncogene, Published online: 12 September 2026; doi:10.1038/s41388-026-03985-5
Development and preclinical evaluation of a decoy DLL4-encoding oncolytic HSV-1 for high-grade glioma
Oncogene, Published online: 12 September 2026; doi:10.1038/s41388-026-03988-2
Circular RNA MCM3 recruits USP49 to stabilize PTBP1 and promote cisplatin resistance in cervical squamous cell carcinoma
Oncogene, Published online: 11 September 2026; doi:10.1038/s41388-026-03986-4
CircRHBDD1(4,5) drives malignant progression of oral squamous cell carcinoma by enhancing DKK1 mRNA stability through facilitating m6A-dependent IGF2BP2 binding
Oncogene, Published online: 11 September 2026; doi:10.1038/s41388-026-03976-6
Tumor-derived CTHRC1 mediates ITGB3-dependent osteoclast differentiation to promote prostate cancer bone metastasis
Oncogene, Published online: 11 September 2026; doi:10.1038/s41388-026-03979-3
Propionyl-CoA catabolism is a metabolic gatekeeper for fatty acid oxidation in pancreatic cancer
Oncogene, Published online: 04 September 2026; doi:10.1038/s41388-026-03966-8
ITGA5 promotes homologous recombination mediated radioresistance in esophageal squamous cell carcinoma by upregulating RAD51AP1 expression
Oncogene, Published online: 04 September 2026; doi:10.1038/s41388-026-03964-w
A step-wise, deterministic and fatal mouse model of myeloid neoplasm with spontaneous acquisition of patient-relevant RTK–RAS mutations
Oncogene, Published online: 03 September 2026; doi:10.1038/s41388-026-03959-7
The RNA-binding protein La/SSB is associated with HNSCC progression and TFAP2C/FSCN1-linked transcriptional regulation
Oncogene, Published online: 01 September 2026; doi:10.1038/s41388-026-03958-8
The GSEC-encoded polypeptide GESP drives colorectal cancer tumorigenesis via NPM1-c-Myc-mediated repression of NDRG1
Oncogene, Published online: 01 September 2026; doi:10.1038/s41388-026-03969-5
Neuromedin U ‘innervation’ reprograms myeloid immunosuppression in neuroendocrine prostate cancer
Oncogene, Published online: 31 August 2026; doi:10.1038/s41388-026-03974-8
Frequently amplified SHANK2 promotes esophageal squamous cell carcinoma progression through the DVL/YAP axis
Oncogene, Published online: 31 August 2026; doi:10.1038/s41388-026-03973-9
POC1A promotes the proliferation, metastasis and stemness of bladder cancer by stabilizing BMI1 via USP7
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