Nature Medicine, Published online: 10 September 2026; doi:10.1038/s41591-026-04703-0CRISP, a vision-based pathology foundation model developed exclusively from frozen section slides, supports treatment decision-making throughout the surgical workflow with superior performance to current foundation models and extensive validation, including in a prospective cohort.

Nature, Published online: 07 September 2026; doi:10.1038/s41586-026-11094-2Author Correction: A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution

Oncogene, Published online: 04 September 2026; doi:10.1038/s41388-026-03966-8ITGA5 promotes homologous recombination mediated radioresistance in esophageal squamous cell carcinoma by upregulating RAD51AP1 expression

Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10572-xA fungal long non-coding RNA from Magnaporthe oryzae translocates into rice cells to sequester a host microRNA that normally represses PKR1, a negative immunity regulator, thereby facilitating infection and revealing a widespread RNA-based pathogen–host interaction mechanism.

Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10464-0Researchers designed two-component proteins forming quasisymmetric cages via geometric frustration, enabling tunable virus-like assemblies for cargo delivery, cellular uptake and studying intracellular diffusion and protein localization.

Nature, Published online: 14 April 2026; doi:10.1038/s41586-026-10493-9Polyclonal selection of immune checkpoint mutations in thyroid autoimmunity

Severe COVID-19 is associated with an increased subsequent risk of lung cancer. Viral pneumonia induces durable lung epigenetic imprinting that promotes tumor-supportive neutrophils and impairs T cell immunity, which is reversible with combined CXCR2 inhibition and PD-L1 blockade.