Nature Medicine, Published online: 16 September 2026; doi:10.1038/s41591-026-04636-8In this single-arm phase 1 trial, an AAV gene therapy carrying the Padua variant of factor IX was well tolerated in 11 adolescents with hemophilia B and led to reductions in annualized bleeding rate.

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11001-9Temporal protein-abundance measurements from systematically perturbed breast cancer cell lines were generated to develop ProteinTalks, a virtual cell model that functions as an operational tool for diverse drug discovery tasks.

Oncogene, Published online: 03 September 2026; doi:10.1038/s41388-026-03959-7The RNA-binding protein La/SSB is associated with HNSCC progression and TFAP2C/FSCN1-linked transcriptional regulation

Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10572-xA fungal long non-coding RNA from Magnaporthe oryzae translocates into rice cells to sequester a host microRNA that normally represses PKR1, a negative immunity regulator, thereby facilitating infection and revealing a widespread RNA-based pathogen–host interaction mechanism.

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10324-xIn situ microscopic single-particle imaging demonstrates the significance of rationally engineered metal–support interfaces for activating the oxygen in bulk catalyst, helping elucidate reaction pathways in catalytic conversions.

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10302-3Author Correction: Gut stem cell necroptosis by genome instability triggers bowel inflammation

Nature Biotechnology, Published online: 11 March 2026; doi:10.1038/s41587-026-03047-xA lysosomal barcoding strategy to quantify endosomal escape of nucleic acids in vivo assesses the performance of branched ionizable lipids for potent liver delivery.