Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10112-7
Genome-wide analysis shows European dogs existed by 14,200 years ago, were already genetically distinct, received less Neolithic Southwest Asian admixture than humans did and contributed substantially to later European dogs.
Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10270-8
Single-nucleus chromatin and RNA sequencing identifies epigenetic chromatin domains that confer vulnerability to paediatric brain tumours such as ependymomas, providing insight into the development of such tumours despite ‘quiet’ genomes.
Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10266-4
Insights into the mechanism by which phosphatidylserine functions as a non-classical inhibitory molecule during T cell exhaustion, and how phosphatidylserine-targeting antibodies enhance T cell responses are explored.
Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10255-7
Cas9 structures explain topology sensing and off-target activation.
Nature Medicine, Published online: 25 March 2026; doi:10.1038/s41591-026-04299-5
Results of the phase 2 POLAR trial show that biomarker-guided treatment in patients with metastatic pancreatic cancer based on homologous repair deficiency leads to encouraging clinical response rates in immune cell-infiltrated tumors.
Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10300-5
At present, only 13.4% of the global land surface meets the World Meteorological Organization requirements for annual precipitation monitoring.
Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10291-3
New evidence suggests that diffusive oxygen transport through the tracheolar–muscle system is not the limiting factor on insect body size.
Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10209-z
Ultrafast electron imaging shows full phase-space dynamics of optical singularities, which can reach superluminal velocities before annihilation and break the particle-like analogy of topological defects.
Nature Medicine, Published online: 24 March 2026; doi:10.1038/s41591-026-04262-4
The first-in-human clinical trial of the LRRK2-targeting antisense oligonucleotide BIIB094 in Parkinson’s disease demonstrates that the treatment is well tolerated and produces dose-dependent reductions in cerebrospinal fluid levels of LRRK2 and phosphorylated Rab10, indicating successful target engagement.
Oncogene, Published online: 23 March 2026; doi:10.1038/s41388-026-03723-x
Aryl hydrocarbon receptor is critical for both AR-dependent and AR-indifferent enzalutamide resistance in castration-resistant prostate cancer
Nature Biotechnology, Published online: 20 March 2026; doi:10.1038/s41587-026-03064-w
This Review discusses the promises and pitfalls of biological AI algorithms and presents a vision for generalist biological artificial intelligence, in which models can perform diverse tasks across biological domains.
Nature Biotechnology, Published online: 20 March 2026; doi:10.1038/s41587-026-03043-1
A tissue-engineered esophageal segment is functional in minipigs.
Nature Cancer, Published online: 18 March 2026; doi:10.1038/s43018-026-01120-7
Murthy and colleagues discussed recent research on the effect of a tucanitib–trastuzumab–capecitabine regimen in patients with HER2+ breast cancer and leptomeningeal metastasis.
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