Oncogene, Published online: 01 April 2026; doi:10.1038/s41388-026-03754-4Targeting FTO shows therapeutic potential in esophageal squamous cell carcinoma by modulating microRNA biogenesis

β-hydroxybutyrate (BHB), the ketone body associated with a ketogenic diet, metabolically reprograms and fuels CAR T cells to achieve proliferation, cytokine production, and superior tumor control. These findings suggest that BHB supplementation may be a practical way to boost adoptive cancer immunotherapy.

Nature Biotechnology, Published online: 13 March 2026; doi:10.1038/s41587-026-03057-9A trispecific macrophage engager amplifies the antitumor response of macrophages in solid tumors.