Oncogene, Published online: 01 April 2026; doi:10.1038/s41388-026-03756-2
Correction: The multifunctional RNA helicase DDX39A drives glioblastoma progression by modulating WISP1 alternative splicing that induces an immunosuppressive macrophage polarization
Oncogene, Published online: 01 April 2026; doi:10.1038/s41388-026-03737-5
LDHA-driven lactate metabolism promotes MDSC activation and immunosuppressive microenvironment in prostate cancer
Oncogene, Published online: 01 April 2026; doi:10.1038/s41388-026-03754-4
Targeting FTO shows therapeutic potential in esophageal squamous cell carcinoma by modulating microRNA biogenesis
Oncogene, Published online: 01 April 2026; doi:10.1038/s41388-026-03740-w
X-linked cancer-associated polypeptide (XCP) from lncRNA1456 modulates PHF8 histone demethylase activity to regulate the epigenome, gene expression, and cellular pathways in breast cancer
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10446-2
Structural modifications in strain-engineered bilayer nickelate thin films
Oncogene, Published online: 01 April 2026; doi:10.1038/s41388-026-03752-6
STAT3-mediated transactivation of NOVA2 promotes lung adenocarcinoma metastasis by splicing SMAD4
Nature, Published online: 01 April 2026; doi:10.1038/d41586-026-01052-3
In-flight experiment suggests lowering soot emissions might not reduce contrail formation — plus, what can be learnt from fakery in science.
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10310-3
DNA damage burden and inadequate repair in CUX2+ cortical layer 2/3 excitatory neurons contributes to selective vulnerability in neuroinflammatory injury.
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10315-y
Development of the pangenome-informed genome assembly (PIGA) workflow enabled the generation of 1,116 diploid genome assemblies (55 de novo and 1,061 pangenome-informed), representing an extensive resource of medically relevant genic variations.
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10322-z
Combining single-cell parallel profiling of genome conformation, histone modifications, chromatin accessibility and gene expression reveals dynamics and intranuclear spatial clustering of epigenome profiles, enabling sophisticated analysis of the regulatory landscape across cell types and tissues.
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10313-0
Findings suggest that neural crest fate bias predominantly emerges within the neural tube, and that only a minor subset of delaminated progenitors retain multipotency to generate both sensory and sympathetic derivatives.
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10301-4
Longitudinal tracking of mice reveals that stable, specialized social roles emerge spontaneously within groups during a foraging task, with dopaminergic activity in the ventral tegmental area driving sex-divergent patterns of specialization.
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10299-9
N-desethyl-fluornitrazene is a µ-opioid receptor agonist derived from nitazenes that has supramaximal intrinsic efficacy that produces analgesia with minimal adverse effects in rodent models.
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10325-w
Researchers created a moiré superlattice in Sb2Te3/FeTe bilayers, producing spatially modulated superconducting gaps directly imaged with Josephson scanning tunnelling microscopy and spectroscopy, tunable by replacing Sb2Te3 with Bi2Te3.
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10304-1
Long-range interactions mediated by protein electric dipole moments have a role in driving the assembly and disassembly of super-signalling complex I for promoting NF-κB signalling.
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10359-0
LIGO–Virgo–KAGRA’s fourth Gravitational-Wave Transient Catalog shows evidence of a clear pair-instability gap in the distribution of binary black-hole secondary masses but is absent in the larger primary masses.
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10290-4
The transcription factor ATF4 is shown to regulate double-stranded DNA repair within vulnerable CUX2+ upper-layer 2/3 cortical neurons, enabling their survival during development.
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10295-z
AhR functions as a neuronal brake on axon regeneration, integrating environmental sensing, protein homeostasis and metabolic signalling to control the balance between stress adaptation and axonal repair.
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10286-0
In-flight observations show that the use of lean-burn combustion succeeds in reducing soot emissions from aircraft—yet contrail ice crystals still form and nucleate on volatile particles.
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10203-5
A study of reproducibility in a stratified random sample of 600 papers published from 2009 to 2018 in 62 journals spanning the social and behavioural sciences finds higher reproducibility among more recent papers and papers from journals that require data sharing.
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