npj Digital Medicine, Published online: 04 April 2026; doi:10.1038/s41746-026-02571-z
Developing psychosocial phenotypes to understand engagement with digital health technologies for heart failure
Oncogene, Published online: 03 April 2026; doi:10.1038/s41388-026-03743-7
TWIST1 mediated transcriptional activation of SPON2 drives colorectal cancer peritoneal metastasis through stromal cell signaling network
Nature Medicine, Published online: 03 April 2026; doi:10.1038/s41591-026-04256-2
Whole-genome phylogenetic analyses have identified a case of monkeypox virus clade IIb lineage in the Republic of the Congo and co-circulation of three clade lineages, emphasizing the importance of improved surveillance given the risk of possible recombination events in the future.
npj Digital Medicine, Published online: 03 April 2026; doi:10.1038/s41746-026-02557-x
Label-free pathological subtyping of non-small cell lung cancer using deep classification and virtual immunohistochemical staining
Cell Death Discovery, Published online: 02 April 2026; doi:10.1038/s41420-026-03009-x
Correction: The cytotoxicity of gomesin peptides is mediated by the glycosphingolipid pathway and lipid-cholesterol interactions
Nature, Published online: 02 April 2026; doi:10.1038/d41586-026-01054-1
Two analyses suggest that quantum computers could crack ubiquitous security keys and cryptocurrencies before the decade is over.
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10446-2
Structural modifications in strain-engineered bilayer nickelate thin films
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10310-3
DNA damage burden and inadequate repair in CUX2+ cortical layer 2/3 excitatory neurons contributes to selective vulnerability in neuroinflammatory injury.
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10313-0
Findings suggest that neural crest fate bias predominantly emerges within the neural tube, and that only a minor subset of delaminated progenitors retain multipotency to generate both sensory and sympathetic derivatives.
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10299-9
N-desethyl-fluornitrazene is a µ-opioid receptor agonist derived from nitazenes that has supramaximal intrinsic efficacy that produces analgesia with minimal adverse effects in rodent models.
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10290-4
The transcription factor ATF4 is shown to regulate double-stranded DNA repair within vulnerable CUX2+ upper-layer 2/3 cortical neurons, enabling their survival during development.
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10203-5
A study of reproducibility in a stratified random sample of 600 papers published from 2009 to 2018 in 62 journals spanning the social and behavioural sciences finds higher reproducibility among more recent papers and papers from journals that require data sharing.
Nature, Published online: 01 April 2026; doi:10.1038/s41586-025-10078-y
A large-scale study on the replicability of claims from social and behavioural science journals reports that about half of the results replicate in the same patterns as the original study.
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10312-1
The rate of axon ensheathment varies within individual myelinating processes, resulting in chains of myelin sheaths connected by bridges consisting of thin cytoplasmic processes that provide flexibility for myelination of highly branched axons.
Nature, Published online: 01 April 2026; doi:10.1038/s41586-025-09844-9
When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10284-2
Megachelicerax cousteaui gen. et sp. nov. is a large soft-bodied arthropod from the middle Cambrian of Utah featuring massive three-segmented chelicerae, along with five pairs of pseudobiramous prosomal limbs with non-foliaceous exopodal rami, and plate-like lamellae-bearing opisthosomal appendages.
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