Oncogene, Published online: 04 April 2026; doi:10.1038/s41388-026-03763-3

Trisomy 8 alters chromatin conformations and activates Y chromosome genes in stem cells to drive a pre-leukemic state

Oncogene, Published online: 04 April 2026; doi:10.1038/s41388-026-03747-3

Pre-operative circulating tumor cells predict worse treatment outcome in patients with high-grade serous ovarian cancer

Oncogene, Published online: 04 April 2026; doi:10.1038/s41388-026-03766-0

S100A6 promotes liver metastasis by activating FGFR3 signaling in BAP1-deficient uveal melanoma

Oncogene, Published online: 04 April 2026; doi:10.1038/s41388-026-03742-8

Deciphering functional intra-tumoral heterogeneity in BRAF^V600E-driven mouse thyroid cancer reveals EMT trajectory and metabolic remodeling

Oncogene, Published online: 04 April 2026; doi:10.1038/s41388-026-03764-2

Spliceosomal component SNRPE drives cell proliferation by regulating CTP synthase 1 mRNA splicing in ovarian cancer

npj Digital Medicine, Published online: 04 April 2026; doi:10.1038/s41746-026-02586-6

Comparison of AI-generated radiology impressions: a multi-stakeholder evaluation

npj Digital Medicine, Published online: 04 April 2026; doi:10.1038/s41746-026-02596-4

Decipher-MR: a vision-language foundation model for 3D MRI representations

npj Digital Medicine, Published online: 04 April 2026; doi:10.1038/s41746-026-02594-6

A neural-symbolic AI agent system for biomedical concept mapping

npj Digital Medicine, Published online: 04 April 2026; doi:10.1038/s41746-026-02573-x

HoloTrauma 3X Triadic AI Co reasoning for robot assisted emergency maxillofacial reconstruction

npj Digital Medicine, Published online: 04 April 2026; doi:10.1038/s41746-026-02571-z

Developing psychosocial phenotypes to understand engagement with digital health technologies for heart failure

npj Digital Medicine, Published online: 04 April 2026; doi:10.1038/s41746-026-02584-8

We re-evaluated GPT-5 using our published pipelines: 500 emergency vignettes across 32 sociodemographic labels for bias, and adversarial prompts with fabricated details. GPT-5 showed no measurable improvement over GPT-4o in sociodemographic-linked decision variation, with several LGBTQIA+ groups flagged for mental-health screening in 100% of cases. Adversarial hallucination rates were higher (65% vs 53% for GPT-4o); a mitigation prompt reduced this to 7.67%.

Nature Medicine, Published online: 03 April 2026; doi:10.1038/s41591-026-04256-2

Whole-genome phylogenetic analyses have identified a case of monkeypox virus clade IIb lineage in the Republic of the Congo and co-circulation of three clade lineages, emphasizing the importance of improved surveillance given the risk of possible recombination events in the future.

Nature Medicine, Published online: 03 April 2026; doi:10.1038/s41591-026-04302-z

Exposome analyses across 34 countries showed that social exposures were associated with faster functional brain aging and physical exposures with faster structural brain aging.

Nature Medicine, Published online: 03 April 2026; doi:10.1038/s41591-026-04305-w

To accelerate therapeutic development and equip stakeholders with clear benchmarks, the authors outline target product profiles for therapies designed to delay or prevent the onset of clinical symptoms of Alzheimer’s disease.

npj Digital Medicine, Published online: 03 April 2026; doi:10.1038/s41746-026-02544-2

User-preference alignment with uncertainty-aware interactive rectification for liver organ and tumor segmentation and analysis from CT images

Nature Cancer, Published online: 03 April 2026; doi:10.1038/s43018-026-01138-x

Leptomeningeal metastases are a devastating complication of solid tumors; how this niche becomes pro-metastatic remains poorly understood. A study now reveals that tumor cells prime a pre-metastatic niche within the leptomeninges via exosome-derived 5-HIAA, triggering vascular leakiness and accumulation of disseminated tumor cells.

Nature Cancer, Published online: 03 April 2026; doi:10.1038/s43018-026-01145-y

Huang, Hou, Yang et al. demonstrate that leptomeningeal metastatic cells favor the formation of a premetastatic niche by remodeling the choroid plexus vasculature through the serotonin metabolite 5-hydroxyindoleacetic acid, which signals into endothelial cells through the aryl hydrocarbon receptor.

Nature Cancer, Published online: 03 April 2026; doi:10.1038/s43018-026-01141-2

Li et al. present PRET, a few-shot system for pan-cancer detection not requiring model fine-tuning, validated it in multicenter datasets and found that it outperformed existing approaches across tasks and pathologists in lymph node metastasis detection.

Nature Cancer, Published online: 03 April 2026; doi:10.1038/s43018-026-01142-1

Izar and colleagues review the insights into cancer biology gained via single-cell analyses and spatial profiling and overview the challenges and opportunities associated with the implementation of these approaches to guide clinical discovery.

Background: Generative artificial intelligence (GenAI) is increasingly used in mental health care, from client-facing chatbots to clinician-facing documentation aids. Psychotherapists’ willingness to rely on—or withhold reliance from—these tools has significant implications for care quality, yet little is known about how practicing clinicians calibrate trust and distrust in GenAI across tasks and contexts. Given that the therapeutic relationship is central to psychotherapy outcomes, understanding how GenAI intersects with this relational foundation is essential for responsible integration. Objective: This study aims to examine (1) psychotherapists’ experiences with, perceptions of, and trust or distrust in GenAI in therapeutic contexts and (2) how they perceive the role of GenAI within the therapeutic relationship and how their perceptions shape their trust and distrust in GenAI. Methods: We conducted a qualitative interview study using semistructured interviews with 18 actively practicing psychotherapists in the United States between January and May 2025. Participants were recruited through professional mailing lists, social media, and snowball sampling. Interviews (≈60 min each) were conducted via Zoom and explored psychotherapists’ experiences with, perceptions of, and trust or distrust in GenAI in therapeutic contexts. Data were analyzed using the general inductive approach, with iterative coding and team-based interpretation to identify themes. Results: Our findings show that psychotherapists’ GenAI adoption was highly individualized and contingent on maintaining professional role integrity—not merely technical oversight. Trust was sustained when GenAI operated in clinician-supervised, supportive roles for low-stakes tasks (eg, documentation and brainstorming), but diminished when control shifted, tasks involved high-stakes clinical judgment, or GenAI threatened to encroach on the authentic human connection central to therapy. Participants articulated conditions for trust that went beyond “human-in-the-loop” monitoring to include preservation of interpretive authority, ethical responsibility, and relational primacy. Distrust also extended to the broader sociotechnical ecosystem, including concerns about commercial incentives, insurance pressures, and the absence of clear organizational guidelines. Conclusions: Psychotherapists’ perspectives offer critical insights into GenAI’s current usages in their professional practices and the conditions under which they are willing to trust and distrust GenAI tools. Their experiences highlight the importance of maintaining clinician control, ensuring contextual appropriateness, and preserving the human connection central to psychotherapy. Future work should further examine how therapeutic orientation, professional experience, and client characteristics shape trust and distrust in GenAI. As GenAI becomes more embedded in mental health care, research is also needed to explore how specific GenAI system features can be responsibly designed to support clinical workflows and enhance therapeutic relationships. Organizational and policy frameworks will be essential to ensure responsible, ethically aligned, and human-centered GenAI deployment in psychotherapy.