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Normal view

Received — 8 April 2026 ⏭ Journals

Zodasiran for cholesterol and triglyceride lowering in patients with hyperlipidemia: final report of phase 1 basket trial

✇Nature Medicine
By: Gerald F. Watts · Russell Scott · David Sullivan · John Baker · Peter Clifton · James Hamilton · Bruce Given · Stacey Melquist · Rong Zhou · Daniel Gaudet · Ira J. Goldberg · Joshua W. Knowles · Nicholas J. Leeper · Robert A. Hegele · Christie M. Ballantyne
7 April 2026 at 08:00

Nature Medicine, Published online: 07 April 2026; doi:10.1038/s41591-026-04307-8

In a phase 1 basket trial, the small interfering RNA zodasiran, targeting ANGPTL3, lowered triglycerides in patients with severe hypertriglyceridemia and lowered both triglycerides and low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolemia.

An international mega-analysis of psychedelic drug effects on brain circuit function

✇Nature Medicine
By: Manesh Girn · Manoj K. Doss · Leor Roseman · Katrin H. Preller · Fernanda Palhano-Fontes · Lorenzo Pasquini · Frederick S. Barrett · Pablo Mallaroni · Natasha L. Mason · Christopher Timmermann · Drummond E. McCulloch · Patrick M. Fisher · Brian S. Winston · Flora Moujaes · Felix Muller · Matthias E. Liechti · Franz X. Vollenweider · Johannes G. Ramaekers · Kim Kuypers · Draulio B. Araujo · Olaf Sporns · Joshua Siegel · Nico Dosenbach · David J. Nutt · Robin L. Carhart-Harris · Emmanuel A. Stamatakis · Danilo Bzdok
6 April 2026 at 08:00

Nature Medicine, Published online: 06 April 2026; doi:10.1038/s41591-026-04287-9

Analysis of neuroimaging datasets across five major psychedelics revealed a shared brain signature and provides a comprehensive insight into how these drugs reorganize brain architecture.

Towards a physics informed digital twin to predict cerebral blood flow and cerebral vascular regulation

✇npj Digital Medicine
By: Jennifer K. Briggs · J. N. Stroh · Soojin Park · Brandon Foreman · Michael M. Tymko · Jay Carr · Melike Sirlanci · Philip N. Ainslie · Richard K. P. Benninger · Tellen D. Bennett · David J. Albers
6 April 2026 at 08:00

npj Digital Medicine, Published online: 06 April 2026; doi:10.1038/s41746-026-02600-x

Towards a physics informed digital twin to predict cerebral blood flow and cerebral vascular regulation
Received — 6 April 2026 ⏭ Journals

Developing psychosocial phenotypes to understand engagement with digital health technologies for heart failure

✇npj Digital Medicine
By: Rachel Tunis · Namuun Clifford · Emily West · Elizabeth Heitkemper · Marissa Burgermaster · Kavita Radhakrishnan
4 April 2026 at 08:00

npj Digital Medicine, Published online: 04 April 2026; doi:10.1038/s41746-026-02571-z

Developing psychosocial phenotypes to understand engagement with digital health technologies for heart failure

<i>TWIST1</i> mediated transcriptional activation of <i>SPON2</i> drives colorectal cancer peritoneal metastasis through stromal cell signaling network

✇Oncogene - Issue - nature.com science feeds
By: Zhuan Zhou · Alessandro La Ferlita · Manoj H. Palavalli · Xiongfeng Chen · Lauren Tyler · Aslam Ejaz · Joal Beane · Patricio M. Polanco · Huocong Huang · Alex C. Kim
3 April 2026 at 08:00

Oncogene, Published online: 03 April 2026; doi:10.1038/s41388-026-03743-7

TWIST1 mediated transcriptional activation of SPON2 drives colorectal cancer peritoneal metastasis through stromal cell signaling network
Received — 4 April 2026 ⏭ Journals

Evidence of monkeypox virus clade IIb lineage A.2.2 in the Republic of the Congo and co-circulation of clade Ia, Ib and clade IIb

✇Nature Medicine
By: Felix Koukouikila-Koussounda · Claude Kwe Yinda · Pembe Issamou Mayangue · Dachel Aymard Eyenet Boussam · Reiche Golmard Elenga · Leadisaelle Hosanna Lenguiya · Ghislain Dzeret Indolo · Bani Reize Vishnou Ampiri · Lucette Nathalie Macosso · Igor Judicaël Louzolo · Isaac Samuel Onyakouang · Jordy Exaucé Lyelet Demboux · Jean Medar Kankou · Aristide Gilbert Nianga · Avelin F. Aghokeng · Vincent Jacobus Munster · Fabien Roch Niama
3 April 2026 at 08:00

Nature Medicine, Published online: 03 April 2026; doi:10.1038/s41591-026-04256-2

Whole-genome phylogenetic analyses have identified a case of monkeypox virus clade IIb lineage in the Republic of the Congo and co-circulation of three clade lineages, emphasizing the importance of improved surveillance given the risk of possible recombination events in the future.

Label-free pathological subtyping of non-small cell lung cancer using deep classification and virtual immunohistochemical staining

✇npj Digital Medicine
By: Zhenya Zang · David A. Dorward · Katherine E. Quiohilag · Andrew DJ Wood · James R. Hopgood · Ahsan R. Akram · Qiang Wang
3 April 2026 at 08:00

npj Digital Medicine, Published online: 03 April 2026; doi:10.1038/s41746-026-02557-x

Label-free pathological subtyping of non-small cell lung cancer using deep classification and virtual immunohistochemical staining

Correction: The cytotoxicity of gomesin peptides is mediated by the glycosphingolipid pathway and lipid-cholesterol interactions

✇Cell Death Discovery nature.com science feeds
By: Isabel Fernandez-Carrasco · Javier Moral-Sanz · Sergey Kurdyukov · Èlia Obis · Lissy Maike Hartmann · Silvia Carina Magalhães Novais · Matthew A. Waller · Naomi McKinnon · Felicity Chung · Francisco Javier Salazar Castejón · Daniel P. Rainho · Zoltan Dekan · Thomas Kremsmayr · Bernhard Jandl · Kristina Eleršič Filipič · Reinald Pamplona · Mariona Jové · Manuel A. Fernandez-Rojo · Gregor Anderluh · Markus Muttenthaler · Paul F. A. Alewood · Jan Procházka · G. Gregory Neely · Evelyne Deplazes · Maria P. Ikonomopoulou
2 April 2026 at 08:00

Cell Death Discovery, Published online: 02 April 2026; doi:10.1038/s41420-026-03009-x

Correction: The cytotoxicity of gomesin peptides is mediated by the glycosphingolipid pathway and lipid-cholesterol interactions

The E3-ome gene-centric compendium reveals the human E3 ligase landscape

✇Cell
By: Ngee Kiat Chua · Tania J. González-Robles · Cameron J. Reddington · Jane Dudley-Fraser · Richard W. Birkinshaw · Jiru Han · Ashleigh Solano · Soon Wei Wong · Tomasz Kochańczyk · Joshua J. Peter · Mark A. Nakasone · Florian Aust · Jacob Munro · Yeh Huei Tong · Julie Iskander · Waruni Abeysekera · Alex Garnham · Hannah Huckstep · Matthew E. Ritchie · Ingrid Wertz · Sarah Hymowitz · Sharad Kumar · Ron C. Conaway · Gilbert G. Privé · Alex N. Bullock · Jeffrey J. Babon · Rachel E. Klevit · Sonja Lorenz · Alessio Ciulli · Eric S. Fischer · Nicolas H. Thomä · Radosław P. Nowak · Brenda A. Schulman · Michael Rapé · Katrin Rittinger · Julia K. Pagan · Melanie Bahlo · Joel P. Mackay · Peter D. Mace · Christopher D. Lima · Ronald T. Hay · David Komander · Bernhard C. Lechtenberg · Claudio A.P. Joazeiro · Michele Pagano · Kay Hofmann · Rebecca Feltham
20 March 2026 at 08:00
The E3-ome defines the human repertoire of ubiquitin E3 ligases, creating a unified resource that maps their diversity across the ubiquitin and ubiquitin-like systems. By consolidating fragmented knowledge, this framework provides a foundation for studying ubiquitin signaling and accelerating discovery.

Cell-type-specific transposon demethylation and TAD remodeling in aging mouse brain

✇Cell
By: Qiurui Zeng · Wenliang Wang · Wei Tian · Amit Klein · Anna Bartlett · Hanqing Liu · Joseph R. Nery · Rosa G. Castanon · Julia Osteen · Nicholas D. Johnson · Wubin Ding · Huaming Chen · Jordan Altshul · Mia Kenworthy · Cynthia Valadon · William Owens · Zhanghao Wu · Maria Luisa Amaral · Nathan R. Zemke · Yuru Song · Cindy Tatiana Báez-Becerra · Silvia Cho · Chumo Chen · Jackson Willier · Stella Cao · Jonathan Rink · Jasper Lee · Ariana Barcoma · Jessica Arzavala · Nora Emerson · Yuancheng Ryan Lu · Bing Ren · M. Margarita Behrens · Joseph R. Ecker
11 March 2026 at 08:00
A multi-omic single-cell atlas of the aging mouse brain reveals cell-type-specific transposon methylation changes, strengthening of 3D genome boundaries, and regionally heterogeneous aging signatures. These findings offer a resource to understand the molecular mechanisms of brain aging and guide future research on neurodegeneration.

Nuclear speckles enable processing of RNA from GC-rich isochores

✇Cell
By: Michał Małszycki · Lisa Martina · İbrahim Avşar Ilık · Daniela Salgado Figueroa · Nirmalya Dasgupta · Menşura Feray Çoşar · Keun-Tae Kim · Gil Carraco · Beatrix Fauler · David Meierhofer · Thorsten Mielke · Hiroo Imai · Cantaş Alev · Ferhat Ay · Tuğçe Aktaş
25 February 2026 at 08:00
Nuclear speckles are key subnuclear structures that regulate gene expression in GC-rich regions. This work shows that the evolution and expansion of core speckle proteins were crucial for the increased GC content seen in amniote genomes.

The MicrobeAtlas database: Global trends and insights into Earth’s microbial ecosystems

✇Cell
By: João Frederico Matias Rodrigues · Janko Tackmann · Lukas Malfertheiner · David Patsch · Eugenio Perez-Molphe-Montoya · Nicolas Näpflin · Daniela Gaio · Gregor Rot · Mihai Danaila · Matteo Eustachio Peluso · Marija Dmitrijeva · Thomas Sebastian Benedikt Schmidt · Christian von Mering
25 February 2026 at 08:00
MicrobeAtlas (www.microbeatlas.org) is an integrated, reference-based resource for truly planet-wide microbiomics, analyzing hundreds of thousands of microbial lineages across diverse environments, conditions, and technologies.
Received — 2 April 2026 ⏭ Journals

DNA damage burden causes selective CUX2 neuron loss in neuroinflammation

✇Nature - Issue - nature.com science feeds
By: Laura Morcom · Wenlong Xia · Zhaoyang Xu · Yashika Awasthi · Celine Geywitz · Matthew O. Ellis · Tomas Noli · Amel Zulji · Daniel Yamamoto · Gemma C. Girdler · Li Kai · Keying Zhu · Mingming Wei · Xiao-Yan Tang · Kimberly K. Hoi · Julio Gonzalez-Maya · Greg J. Duncan · Adrien M. Vaquie · Diana Gold Diaz · Riki Kawaguchi · Erdong Liu · Yu Sun · Denny Yang · Gregory D. Jordan · I-Ling Lu · Staffan Holmqvist · Theresa Bartels · Katherine Ridley · Jennifer Ja-Yoon Choi · Santos J. Franco · Eric J. Huang · Ben Emery · Daniel Geschwind · Lucas Schirmer · Gabriel Balmus · Brian Popko · Stephen P. J. Fancy · David H. Rowitch
1 April 2026 at 08:00

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10310-3

DNA damage burden and inadequate repair in CUX2+ cortical layer 2/3 excitatory neurons contributes to selective vulnerability in neuroinflammatory injury.

Developmental organization of sensory and sympathetic ganglia

✇Nature - Issue - nature.com science feeds
By: Keng Ioi Vong · Yanina D. Alvarez · Qingquan Zhang · Jiaming Weng · Geoffroy Noel · Scott T. Barton · Changuk Chung · Robyn Howarth · Naomi Meave · Fiza Jiwani · Sai B. Patarlapalli · Fenyong Yao · Fugui Zhu · Chelsea Barrows · Arzoo Patel · Jian Xiong Wang · Neil C. Chi · Stephen F. Kingsmore · Melanie D. White · Xiaoxu Yang · Joseph G. Gleeson
1 April 2026 at 08:00

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10313-0

Findings suggest that neural crest fate bias predominantly emerges within the neural tube, and that only a minor subset of delaminated progenitors retain multipotency to generate both sensory and sympathetic derivatives.

A µ-opioid receptor superagonist analgesic with minimal adverse effects

✇Nature - Issue - nature.com science feeds
By: Juan L. Gomez · Emilya N. Ventriglia · Zachary J. Frangos · Agnieszka Sulima · Michael J. Robertson · Michael D. Sacco · Reece C. Budinich · Ilinca M. Giosan · Tongzhen Xie · Oscar Solis · Anna E. Tischer · Jennifer M. Bossert · Kiera E. Caldwell · Hannah Bonbrest · Amelie Essmann · Zelai M. Garçon-Poca · Shinbe Choi · Michael R. Noya · Feonil Limiac · Ali Arce · Grant C. Glatfelter · Margaret Robinson · Li Chen · Angelina A. Mullarkey · Dain R. Brademan · Garrett Enten · William Dunne · César Quiroz · Ingrid Schoenborn · Chae Bin Lee · Rana Rais · Daniel P. Holt · Robert F. Dannals · Lei Shi · Ruth Hüttenhain · Sergi Ferré · Eugene Kiyatkin · Jordi Bonaventura · Yavin Shaham · Venetia Zachariou · Michael H. Baumann · Georgios Skiniotis · Kenner C. Rice · Michael Michaelides
1 April 2026 at 08:00

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10299-9

N-desethyl-fluornitrazene is a µ-opioid receptor agonist derived from nitazenes that has supramaximal intrinsic efficacy that produces analgesia with minimal adverse effects in rodent models.

Expansion of outer cortical CUX2 neurons requires adaptations for DNA repair

✇Nature - Issue - nature.com science feeds
By: Wenlong Xia · Laura Morcom · Zhaoyang Xu · I-Ling Lu · Qing Wang · Kimberly K. Hoi · Mingming Wei · Keying Zhu · Gregory Jordan · Xiao-Yan Tang · Julio Gonzalez-Maya · Vanesa S. Mattera · Sophia M. Panigrahi · Riki Kawaguchi · Ben Emery · Santos J. Franco · Daniel H. Geschwind · Brian Popko · David H. Rowitch · Stephen P. J. Fancy
1 April 2026 at 08:00

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10290-4

The transcription factor ATF4 is shown to regulate double-stranded DNA repair within vulnerable CUX2+ upper-layer 2/3 cortical neurons, enabling their survival during development.
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