Nature - Issue - nature.com science feeds
De novo design of miniproteins targeting GPCRs Edin Muratspahić · David Feldman · David E. Kim · Xiangli Qu · Ana-Maria Bratovianu · Paula Rivera-Sánchez · Jan Hendrik Voss · Emil P. T. Hertz · Mads Jeppesen · Federica Dimitri · Kensuke Sakamoto · Amrita Nallathambi · Pia Peceli · Jianjun Cao · Brian P. Cary · Matthew J. Belousoff · Peter Keov · Phuc N. H. Trinh · Qingchao Chen · Yue Ren · Justyn Fine · Sudha Mishra · Annu Dalal · Shachie Sinha · Ramanuj Banerjee · Manisankar Ganguly · Karthik Varappalayam Karuppusamy · Isaac Sappington · Thomas Schlichthaerle · Jason Z. Zhang · Arvind Pillai · Brian Coventry · Ljubica Mihaljević · Magnus Bauer · Susana Vázquez Torres · Amir Motmaen · Gyu Rie Lee · Long Tran · Xinru Wang · Inna Goreshnik · Dionne K. Vafeados · Justin E. Svendsen · Parisa Hosseinzadeh · Nicolai Lindegaard · Matthäus Brandt · Yann Waltenspühl · Kristine Deibler · Lukas Deweid · Anja Bennett · Jendrik Schöppe · Tiantang Dong · Xiaoli Yan · Luke Oostdyk · William Cao · Lakshmi Anantharaman · Johan J. Weisser · Jesper Frank Bastlund · Christoffer Bundgaard · Ayodeji A. Asuni · Justin G. Englis
Nature, Published online: 21 May 2026; doi:10.1038/s41586-026-10656-8De novo design of miniproteins targeting GPCRs
21 May 2026 at 08:00

De novo design of miniproteins targeting GPCRs

Nature - Issue - nature.com science feeds

By: Edin Muratspahić · David Feldman · David E. Kim · Xiangli Qu · Ana-Maria Bratovianu · Paula Rivera-Sánchez · Jan Hendrik Voss · Emil P. T. Hertz · Mads Jeppesen · Federica Dimitri · Kensuke Sakamoto · Amrita Nallathambi · Pia Peceli · Jianjun Cao · Brian P. Cary · Matthew J. Belousoff · Peter Keov · Phuc N. H. Trinh · Qingchao Chen · Yue Ren · Justyn Fine · Sudha Mishra · Annu Dalal · Shachie Sinha · Ramanuj Banerjee · Manisankar Ganguly · Karthik Varappalayam Karuppusamy · Isaac Sappington · Thomas Schlichthaerle · Jason Z. Zhang · Arvind Pillai · Brian Coventry · Ljubica Mihaljević · Magnus Bauer · Susana Vázquez Torres · Amir Motmaen · Gyu Rie Lee · Long Tran · Xinru Wang · Inna Goreshnik · Dionne K. Vafeados · Justin E. Svendsen · Parisa Hosseinzadeh · Nicolai Lindegaard · Matthäus Brandt · Yann Waltenspühl · Kristine Deibler · Lukas Deweid · Anja Bennett · Jendrik Schöppe · Tiantang Dong · Xiaoli Yan · Luke Oostdyk · William Cao · Lakshmi Anantharaman · Johan J. Weisser · Jesper Frank Bastlund · Christoffer Bundgaard · Ayodeji A. Asuni · Justin G. Englis

21 May 2026 at 08:00

Nature, Published online: 21 May 2026; doi:10.1038/s41586-026-10656-8

Oncogene - Issue - nature.com science feeds
circPARPBP promotes cancer stemness and chemoresistance in triple-negative breast cancer through recruiting SRCAP complex to activate CCL20 transcription Bo Chen · Kang Ma · Wenhuan Zhong · Yunjie Wang · Cheng Long · Xueyan Mao · Hailin Tang · Xudong Zhu · Anli Yang · Peng Liu
Oncogene, Published online: 21 May 2026; doi:10.1038/s41388-026-03819-4circPARPBP promotes cancer stemness and chemoresistance in triple-negative breast cancer through recruiting SRCAP complex to activate CCL20 transcription
21 May 2026 at 08:00

circPARPBP promotes cancer stemness and chemoresistance in triple-negative breast cancer through recruiting SRCAP complex to activate CCL20 transcription

Oncogene - Issue - nature.com science feeds

By: Bo Chen · Kang Ma · Wenhuan Zhong · Yunjie Wang · Cheng Long · Xueyan Mao · Hailin Tang · Xudong Zhu · Anli Yang · Peng Liu

21 May 2026 at 08:00

Oncogene, Published online: 21 May 2026; doi:10.1038/s41388-026-03819-4

circPARPBP promotes cancer stemness and chemoresistance in triple-negative breast cancer through recruiting SRCAP complex to activate CCL20 transcription

Nature - Issue - nature.com science feeds
Clinical application of base editing for treating β-thalassaemia Yongrong Lai · Rongrong Liu · Lijie Wang · Xu-Kai Ma · Yaliang Li · Gaohui Yang · Lingling Shi · Yi-Lin Guo · Zhenbin Wei · Xuemei Zhou · Wenchao Xu · Yaofeng Hou · Annarita Miccio · Bei Yang · Xiaodun Mou · Li Yang · Jia Chen
Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10342-9A clinical phase 1 trial of a single infusion of CS-101, CD34+ cells modified using a transformer base editor to reactivate fetal haemoglobin production, led to early and enduring transfusion independence in patients with β-thalassaemia.
8 April 2026 at 08:00

Clinical application of base editing for treating β-thalassaemia

Nature - Issue - nature.com science feeds

By: Yongrong Lai · Rongrong Liu · Lijie Wang · Xu-Kai Ma · Yaliang Li · Gaohui Yang · Lingling Shi · Yi-Lin Guo · Zhenbin Wei · Xuemei Zhou · Wenchao Xu · Yaofeng Hou · Annarita Miccio · Bei Yang · Xiaodun Mou · Li Yang · Jia Chen

8 April 2026 at 08:00

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10342-9

A clinical phase 1 trial of a single infusion of CS-101, CD34+ cells modified using a transformer base editor to reactivate fetal haemoglobin production, led to early and enduring transfusion independence in patients with β-thalassaemia.