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Normal view

Deubiquitinase USP35 regulates MDM4 degradation to promote endothelial ferroptosis and renal injury progression

Cell Death Discovery, Published online: 25 May 2026; doi:10.1038/s41420-026-03128-5

Deubiquitinase USP35 regulates MDM4 degradation to promote endothelial ferroptosis and renal injury progression

A pathogen lncRNA secreted into rice sequesters a host miRNA for virulence

Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10572-x

A fungal long non-coding RNA from Magnaporthe oryzae translocates into rice cells to sequester a host microRNA that normally represses PKR1, a negative immunity regulator, thereby facilitating infection and revealing a widespread RNA-based pathogen–host interaction mechanism.

Pyruvate is a natural suppressor of interferon signaling by inducing STAT1 protein pyruvylation

Yibo et al. identify protein pyruvylation as a post-translational modification that can modulate immune signaling and host antiviral response.

TRIM21-mediated degradation of HILPDA overcomes anti-PD-1 immunotherapy resistance in breast cancer by limiting PD-L1 palmitoylation

Oncogene, Published online: 24 March 2026; doi:10.1038/s41388-026-03728-6

TRIM21-mediated degradation of HILPDA overcomes anti-PD-1 immunotherapy resistance in breast cancer by limiting PD-L1 palmitoylation

PAK4 functions as an immune suppressor by reprogramming the phosphatidylcholine metabolism of CD8 + T cells within the glioblastoma tumor microenvironment

Oncogene, Published online: 23 March 2026; doi:10.1038/s41388-026-03734-8

PAK4 functions as an immune suppressor by reprogramming the phosphatidylcholine metabolism of CD8 + T cells within the glioblastoma tumor microenvironment

C-Jun-activated S100A10 promotes malignant progression via in diminishing ubiquitin-dependent degradation of vimentin in gastric cancer

Oncogene, Published online: 06 March 2026; doi:10.1038/s41388-026-03720-0

C-Jun-activated S100A10 promotes malignant progression via in diminishing ubiquitin-dependent degradation of vimentin in gastric cancer
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