Science, Ahead of Print.

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10384-zThermoCas9, a genome-editing enzyme that is sensitive to the DNA methylation status of the target locus, is characterized and shows promise for targeting hypomethylated DNA regions in cancer cells.

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10416-8A genome-to-genome association study identifies host and viral risk factors that interact to drive nasopharyngeal carcinoma endemicity in southern China.

A mitochondrial transplantation approach rescues mitochondrial deficiency and prevents mitochondrial DNA depletion syndrome, Leigh syndrome, and Parkinson’s disease in cellular and mouse models.

(Cell 188, 6283–6300.e1–e10; October 30, 2025)

Enhancing circadian amplitude in mouse hypothalamic paraventricular nucleus neurons by 3′-deoxyadenosine treatment alleviates age-related pathologies and extends lifespan.

Nature, Published online: 31 March 2026; doi:10.1038/s41586-026-10442-6Structure of the mouse cytoplasmic lattice

Cell Death Discovery, Published online: 12 March 2026; doi:10.1038/s41420-026-02995-2CSF1R T567M mutation induces microglial dysfunction and synaptic impairment in patient iPSC-derived cerebral organoids of CSF1R-related disorder

Oncogene, Published online: 06 March 2026; doi:10.1038/s41388-026-03708-wDexamethasone promotes neutrophil ROS-mediated tumor killing through the glucocorticoid receptor