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Received — 27 May 2026 ⏭ Oncogene - Issue - nature.com science feeds

Oncogene - Issue - nature.com science feeds
GPX8<sup>+</sup> cancer-associated fibroblast-derived lactate contributes to lenvatinib resistance by facilitating BRPF1 expression through histone H3 lysine 18 lactylation in hepatocellular carcinoma Qinsi Wan · Jie Li · Mengzhou Guo · Jiahao Hu · Liangliang Bai · Meixia Zhang · Bimin Li · Yuan Fang · Xiaojing Du · Xingxing Zhang · Li Song · Sinuo Chen · Zhuoran Qi · Jinglin Xia · Bei Lv · Mingyan He
Oncogene, Published online: 22 May 2026; doi:10.1038/s41388-026-03711-1GPX8+ cancer-associated fibroblast-derived lactate contributes to lenvatinib resistance by facilitating BRPF1 expression through histone H3 lysine 18 lactylation in hepatocellular carcinoma
22 May 2026 at 08:00

GPX8<sup>+</sup> cancer-associated fibroblast-derived lactate contributes to lenvatinib resistance by facilitating BRPF1 expression through histone H3 lysine 18 lactylation in hepatocellular carcinoma

Oncogene - Issue - nature.com science feeds

By: Qinsi Wan · Jie Li · Mengzhou Guo · Jiahao Hu · Liangliang Bai · Meixia Zhang · Bimin Li · Yuan Fang · Xiaojing Du · Xingxing Zhang · Li Song · Sinuo Chen · Zhuoran Qi · Jinglin Xia · Bei Lv · Mingyan He

22 May 2026 at 08:00

Oncogene, Published online: 22 May 2026; doi:10.1038/s41388-026-03711-1

GPX8⁺ cancer-associated fibroblast-derived lactate contributes to lenvatinib resistance by facilitating BRPF1 expression through histone H3 lysine 18 lactylation in hepatocellular carcinoma