NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance
3 July 2024 at 08:00
Nature, Published online: 03 July 2024; doi:10.1038/s41586-024-07620-9
Lactylation of NBS1 by TIP60 promotes homologous recombination-driven DNA repair and resistance to chemotherapy in cancer cells and links altered cancer cell metabolism to increase genome stability.