Normal view
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cs.AI, q-bio.NC updates on arXiv.org
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MemSearcher: Training LLMs to Reason, Search and Manage Memory via End-to-End Reinforcement Learning
arXiv:2511.02805v1 Announce Type: cross Abstract: Typical search agents concatenate the entire interaction history into the LLM context, preserving information integrity but producing long, noisy contexts, resulting in high computation and memory costs. In contrast, using only the current turn avoids this overhead but discards essential information. This trade-off limits the scalability of search agents. To address this challenge, we propose MemSearcher, an agent workflow that iteratively maint
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Cell Death Discovery nature.com science feeds
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Protein lipoylation in cancer: metabolic reprogramming and therapeutic potential
Cell Death Discovery, Published online: 02 September 2025; doi:10.1038/s41420-025-02718-zProtein lipoylation in cancer: metabolic reprogramming and therapeutic potential
Protein lipoylation in cancer: metabolic reprogramming and therapeutic potential
Cell Death Discovery, Published online: 02 September 2025; doi:10.1038/s41420-025-02718-z
Protein lipoylation in cancer: metabolic reprogramming and therapeutic potential-
(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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An organoid co-culture model for probing systemic anti-tumor immunity in lung cancer
Cell Stem Cell. 2025 Jun 6:S1934-5909(25)00191-2. doi: 10.1016/j.stem.2025.05.011. Online ahead of print.ABSTRACTDeciphering interactions between tumor micro- and systemic immune macroenvironments is essential for developing more effective cancer diagnosis and therapeutic strategies. Here, we established a gel-liquid interface (GLI) co-culture model of lung cancer organoids (LCOs) and paired peripheral-blood mononuclear cells (PBMCs), featuring enhanced interactions between immune cells and tumo
An organoid co-culture model for probing systemic anti-tumor immunity in lung cancer
Cell Stem Cell. 2025 Jun 6:S1934-5909(25)00191-2. doi: 10.1016/j.stem.2025.05.011. Online ahead of print.
ABSTRACT
Deciphering interactions between tumor micro- and systemic immune macroenvironments is essential for developing more effective cancer diagnosis and therapeutic strategies. Here, we established a gel-liquid interface (GLI) co-culture model of lung cancer organoids (LCOs) and paired peripheral-blood mononuclear cells (PBMCs), featuring enhanced interactions between immune cells and tumor organoids for optimized simulation of in vivo systemic anti-tumor immunity. By constructing a cohort of lung cancer patients, we demonstrated that the responses of GLI models under αPD1 treatment reflected the immunotherapy outcomes of the corresponding patients precisely. Furthermore, we dissected the various tumor immune processes mediated by PBMC-derived T cells within GLI models through functional multi-omics analyses, along with the characterization of circulating tumor-reactive T cells (GNLY+CD44+CD9+) with effector memory-like phenotypes as a potential indicator of immunotherapy efficacy. Our findings indicate that the GLI co-culture model can be used to develop diagnostic strategies for precision immunotherapies, as well as understanding the underlying mechanisms.
PMID:40513558 | DOI:10.1016/j.stem.2025.05.011
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Oncogene - Issue - nature.com science feeds
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Identification of novel germline mutations in <i>FUT7</i> and <i>EXT1</i> linked with hereditary multiple exostoses
Oncogene, Published online: 17 December 2024; doi:10.1038/s41388-024-03254-3Identification of novel germline mutations in FUT7 and EXT1 linked with hereditary multiple exostoses
Identification of novel germline mutations in <i>FUT7</i> and <i>EXT1</i> linked with hereditary multiple exostoses
Oncogene, Published online: 17 December 2024; doi:10.1038/s41388-024-03254-3
Identification of novel germline mutations in FUT7 and EXT1 linked with hereditary multiple exostoses-
Nature - Issue - nature.com science feeds
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Synthesis of portimines reveals the basis of their anti-cancer activity
Nature, Published online: 20 September 2023; doi:10.1038/s41586-023-06535-1A scalable total synthesis of portimines enables structural reassignment of portimine B and in-depth functional evaluation of portimine A, revealing that portimine A induces translation inhibition selectively in human cancer cells and is efficacious in vivo tumour-clearance models.
Synthesis of portimines reveals the basis of their anti-cancer activity
Nature, Published online: 20 September 2023; doi:10.1038/s41586-023-06535-1
A scalable total synthesis of portimines enables structural reassignment of portimine B and in-depth functional evaluation of portimine A, revealing that portimine A induces translation inhibition selectively in human cancer cells and is efficacious in vivo tumour-clearance models.-
Nature - Issue - nature.com science feeds
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Scientific discovery in the age of artificial intelligence
Nature, Published online: 02 August 2023; doi:10.1038/s41586-023-06221-2The advances in artificial intelligence over the past decade are examined, with a discussion on how artificial intelligence systems can aid the scientific process and the central issues that remain despite advances.
Scientific discovery in the age of artificial intelligence
Nature, Published online: 02 August 2023; doi:10.1038/s41586-023-06221-2
The advances in artificial intelligence over the past decade are examined, with a discussion on how artificial intelligence systems can aid the scientific process and the central issues that remain despite advances.