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cs.AI, q-bio.NC updates on arXiv.org
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Aetheria: A multimodal interpretable content safety framework based on multi-agent debate and collaboration
arXiv:2512.02530v1 Announce Type: new Abstract: The exponential growth of digital content presents significant challenges for content safety. Current moderation systems, often based on single models or fixed pipelines, exhibit limitations in identifying implicit risks and providing interpretable judgment processes. To address these issues, we propose Aetheria, a multimodal interpretable content safety framework based on multi-agent debate and collaboration.Employing a collaborative architecture
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Omics in Hepatocellular
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Leveraging artificial intelligence to validate traditional biomarkers and drug targets in liver cancer recovery: a mini review
Front Pharmacol. 2025 Oct 17;16:1697608. doi: 10.3389/fphar.2025.1697608. eCollection 2025.ABSTRACTHepatocellular carcinoma (HCC) remains a leading cause of cancer death, and recovery after therapy is shaped by heterogeneous etiologies, genomes and microenvironments. Targeted and immunotherapy combinations have broadened first-line options; yet durable benefit is uneven, and serum/imaging anchors (AFP, AFP-L3%, PIVKA-II, LI-RADS/mRECIST) incompletely resolve residual disease or functional restor
Leveraging artificial intelligence to validate traditional biomarkers and drug targets in liver cancer recovery: a mini review
Front Pharmacol. 2025 Oct 17;16:1697608. doi: 10.3389/fphar.2025.1697608. eCollection 2025.
ABSTRACT
Hepatocellular carcinoma (HCC) remains a leading cause of cancer death, and recovery after therapy is shaped by heterogeneous etiologies, genomes and microenvironments. Targeted and immunotherapy combinations have broadened first-line options; yet durable benefit is uneven, and serum/imaging anchors (AFP, AFP-L3%, PIVKA-II, LI-RADS/mRECIST) incompletely resolve residual disease or functional restoration. In this review we summarise AI-enabled radiology, digital pathology and multi-omic/liquid-biopsy analytics that test and refine traditional biomarkers and drug-target readouts, and appraise translational opportunities in composite surveillance and recovery forecasting. We also discuss enduring challenges-including assay standardisation, spectrum bias, data leakage, domain shift and limited prospective external validation-that temper implementation. By integrating established anchors (AFP/AFP-L3%, PIVKA-II, ALBI, contrast-enhanced hallmarks) with AI-derived signals (radiomics/pathomics, cfDNA methylation) and pathway contexts (VEGF-VEGFR, WNT/β-catenin), emerging strategies align predictions with clinical endpoints, individualise therapy and chart hepatic function. Our synthesis provides an appraisal of AI-traditional integration in liver cancer recovery and outlines pragmatic standards-analytical robustness, transparent reporting and prospective, guideline-conformant evaluation-required for clinical adoption. We hope these insights will aid researchers and clinicians as they implement more effective, individualised monitoring and treatment pathways.
PMID:41181592 | PMC:PMC12575369 | DOI:10.3389/fphar.2025.1697608
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Oncogene - Issue - nature.com science feeds
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ScRNA-seq of gastric cancer tissues reveals differences in the immune microenvironment of primary tumors and metastases
Oncogene, Published online: 30 March 2024; doi:10.1038/s41388-024-03012-5ScRNA-seq of gastric cancer tissues reveals differences in the immune microenvironment of primary tumors and metastases
ScRNA-seq of gastric cancer tissues reveals differences in the immune microenvironment of primary tumors and metastases
Oncogene, Published online: 30 March 2024; doi:10.1038/s41388-024-03012-5
ScRNA-seq of gastric cancer tissues reveals differences in the immune microenvironment of primary tumors and metastases-
Cell Death Discovery nature.com science feeds
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N1-Methyladenosine modification of mRNA regulates neuronal gene expression and oxygen glucose deprivation/reoxygenation induction
Cell Death Discovery, Published online: 12 May 2023; doi:10.1038/s41420-023-01458-2N1-Methyladenosine modification of mRNA regulates neuronal gene expression and oxygen glucose deprivation/reoxygenation induction
N1-Methyladenosine modification of mRNA regulates neuronal gene expression and oxygen glucose deprivation/reoxygenation induction
Cell Death Discovery, Published online: 12 May 2023; doi:10.1038/s41420-023-01458-2
N1-Methyladenosine modification of mRNA regulates neuronal gene expression and oxygen glucose deprivation/reoxygenation induction