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Cancer biomarkers: Emerging trends and clinical implications for personalized treatment

Cancer biomarkers have transformed oncology, enabling treatments tailored to each tumor’s unique profile. This review highlights the field’s progress due to advancements in understanding cancer biology, testing methods, and understanding of the immune microenvironment to advance precision oncology for improved patient outcomes.

Translation of tissue-based artificial intelligence into clinical practice: from discovery to adoption

Oncogene, Published online: 24 October 2023; doi:10.1038/s41388-023-02857-6

Translation of tissue-based artificial intelligence into clinical practice: from discovery to adoption

Histone demethylase KDM5D upregulation drives sex differences in colon cancer

Nature, Published online: 21 June 2023; doi:10.1038/s41586-023-06254-7

A murine colorectal cancer (CRC) model shows that mutant KRAS-STAT4-mediated upregulation of Y chromosome KDM5D contributes to the sex differences in KRAS-mutant CRC, providing an actionable therapeutic strategy for metastasis risk reduction for men afflicted with KRAS-mutant CRC.

Spatial epigenome–transcriptome co-profiling of mammalian tissues

Nature, Published online: 15 March 2023; doi:10.1038/s41586-023-05795-1

The authors present two technologies for spatially resolved, genome-wide, joint profiling of the epigenome and transcriptome by cosequencing chromatin accessibility and gene expression, or histone modifications and gene expression on the same tissue section at near-single-cell resolution.

Epigenetic aging in patients diagnosed with coronary artery disease: results of the LipidCardio study

People age biologically at different rates. Epigenetic clock-derived DNA methylation age acceleration (DNAmAA) is among the most promising markers proposed to assess the interindividual differences in biologic...

DNA methylation in human gastric epithelial cells defines regional identity without restricting lineage plasticity

Epigenetic modifications in mammalian DNA are commonly manifested by DNA methylation. In the stomach, altered DNA methylation patterns have been observed following chronic Helicobacter pylori infections and in ga...

The co-evolution of the genome and epigenome in colorectal cancer

Nature, Published online: 26 October 2022; doi:10.1038/s41586-022-05202-1

A study maps genetic and epigenetic heterogeneity of primary colorectal adenomas and cancers at single-clone resolution through spatial multi-omic profiling of individual glands and adjacent normal tissue.

Phenotypic plasticity and genetic control in colorectal cancer evolution

Nature, Published online: 26 October 2022; doi:10.1038/s41586-022-05311-x

Intratumour genetic ancestry only infrequently affects gene expression traits and subclonal evolution in colorectal cancer, with most genetic intratumour variation having no detected phenotypic consequence and transcriptional plasticity being widespread within a tumour.
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