Normal view
-
Cell
-
Transposable element exonization generates a reservoir of evolving and functional protein isoforms
Transposable element exonization by unannotated splicing events produces stable protein isoforms with acquired functions that are subject to evolutionary selection.
-
Cell
-
Cancer biomarkers: Emerging trends and clinical implications for personalized treatment
Cancer biomarkers have transformed oncology, enabling treatments tailored to each tumor’s unique profile. This review highlights the field’s progress due to advancements in understanding cancer biology, testing methods, and understanding of the immune microenvironment to advance precision oncology for improved patient outcomes.
Cancer biomarkers: Emerging trends and clinical implications for personalized treatment
-
Nature - Issue - nature.com science feeds
-
‘All of Us’ genetics chart stirs unease over controversial depiction of race
Nature, Published online: 23 February 2024; doi:10.1038/d41586-024-00568-wDebate over figure connecting genes, race and ethnicity reignites concerns among geneticists about how to represent human diversity.
‘All of Us’ genetics chart stirs unease over controversial depiction of race
Nature, Published online: 23 February 2024; doi:10.1038/d41586-024-00568-w
Debate over figure connecting genes, race and ethnicity reignites concerns among geneticists about how to represent human diversity.-
Nature - Issue - nature.com science feeds
-
Author Correction: Genotyping, sequencing and analysis of 140,000 adults from Mexico City
Nature, Published online: 08 February 2024; doi:10.1038/s41586-024-07051-6Author Correction: Genotyping, sequencing and analysis of 140,000 adults from Mexico City
Author Correction: Genotyping, sequencing and analysis of 140,000 adults from Mexico City
Nature, Published online: 08 February 2024; doi:10.1038/s41586-024-07051-6
Author Correction: Genotyping, sequencing and analysis of 140,000 adults from Mexico City-
Nature - Issue - nature.com science feeds
-
NIH researchers vote to form a union for the first time
Nature, Published online: 07 December 2023; doi:10.1038/d41586-023-03898-3The new bargaining group will represent thousands of early-career scientists at the US National Institutes of Health.
NIH researchers vote to form a union for the first time
Nature, Published online: 07 December 2023; doi:10.1038/d41586-023-03898-3
The new bargaining group will represent thousands of early-career scientists at the US National Institutes of Health.-
Nature - Issue - nature.com science feeds
-
Are your organs ageing well? The blood holds clues
Nature, Published online: 06 December 2023; doi:10.1038/d41586-023-03821-wOne organ in a person’s body can age faster than the rest — with implications for health and mortality.
Are your organs ageing well? The blood holds clues
Nature, Published online: 06 December 2023; doi:10.1038/d41586-023-03821-w
One organ in a person’s body can age faster than the rest — with implications for health and mortality.-
Nature - Issue - nature.com science feeds
-
AI ‘breakthrough’: neural net has human-like ability to generalize language
Nature, Published online: 25 October 2023; doi:10.1038/d41586-023-03272-3A neural-network-based artificial intelligence outperforms ChatGPT at quickly folding new words into its lexicon, a key aspect of human intelligence.
AI ‘breakthrough’: neural net has human-like ability to generalize language
Nature, Published online: 25 October 2023; doi:10.1038/d41586-023-03272-3
A neural-network-based artificial intelligence outperforms ChatGPT at quickly folding new words into its lexicon, a key aspect of human intelligence.-
Oncogene - Issue - nature.com science feeds
-
Translation of tissue-based artificial intelligence into clinical practice: from discovery to adoption
Oncogene, Published online: 24 October 2023; doi:10.1038/s41388-023-02857-6Translation of tissue-based artificial intelligence into clinical practice: from discovery to adoption
Translation of tissue-based artificial intelligence into clinical practice: from discovery to adoption
Oncogene, Published online: 24 October 2023; doi:10.1038/s41388-023-02857-6
Translation of tissue-based artificial intelligence into clinical practice: from discovery to adoption-
Nature - Issue - nature.com science feeds
-
Histone demethylase KDM5D upregulation drives sex differences in colon cancer
Nature, Published online: 21 June 2023; doi:10.1038/s41586-023-06254-7A murine colorectal cancer (CRC) model shows that mutant KRAS-STAT4-mediated upregulation of Y chromosome KDM5D contributes to the sex differences in KRAS-mutant CRC, providing an actionable therapeutic strategy for metastasis risk reduction for men afflicted with KRAS-mutant CRC.
Histone demethylase KDM5D upregulation drives sex differences in colon cancer
Nature, Published online: 21 June 2023; doi:10.1038/s41586-023-06254-7
A murine colorectal cancer (CRC) model shows that mutant KRAS-STAT4-mediated upregulation of Y chromosome KDM5D contributes to the sex differences in KRAS-mutant CRC, providing an actionable therapeutic strategy for metastasis risk reduction for men afflicted with KRAS-mutant CRC.-
Nature - Issue - nature.com science feeds
-
COVID-origins data from Wuhan market published: what scientists think
Nature, Published online: 05 April 2023; doi:10.1038/d41586-023-00998-yFirst peer-reviewed analysis of the Chinese swabs confirms animal DNA was present in samples that tested positive for SARS-CoV-2.
COVID-origins data from Wuhan market published: what scientists think
Nature, Published online: 05 April 2023; doi:10.1038/d41586-023-00998-y
First peer-reviewed analysis of the Chinese swabs confirms animal DNA was present in samples that tested positive for SARS-CoV-2.-
Nature - Issue - nature.com science feeds
-
Spatial epigenome–transcriptome co-profiling of mammalian tissues
Nature, Published online: 15 March 2023; doi:10.1038/s41586-023-05795-1The authors present two technologies for spatially resolved, genome-wide, joint profiling of the epigenome and transcriptome by cosequencing chromatin accessibility and gene expression, or histone modifications and gene expression on the same tissue section at near-single-cell resolution.
Spatial epigenome–transcriptome co-profiling of mammalian tissues
Nature, Published online: 15 March 2023; doi:10.1038/s41586-023-05795-1
The authors present two technologies for spatially resolved, genome-wide, joint profiling of the epigenome and transcriptome by cosequencing chromatin accessibility and gene expression, or histone modifications and gene expression on the same tissue section at near-single-cell resolution.-
Nature - Issue - nature.com science feeds
-
The mice with two dads: scientists create eggs from male cells
Nature, Published online: 09 March 2023; doi:10.1038/d41586-023-00717-7Proof-of-concept mouse experiment will have a long road before use in humans is possible.
The mice with two dads: scientists create eggs from male cells
Nature, Published online: 09 March 2023; doi:10.1038/d41586-023-00717-7
Proof-of-concept mouse experiment will have a long road before use in humans is possible.-
Nature - Issue - nature.com science feeds
-
FDA to require diversity plan for clinical trials
Nature, Published online: 16 February 2023; doi:10.1038/d41586-023-00469-4US regulatory agency makes ‘big change’ to increase the number of participants from under-represented groups in drug testing.
FDA to require diversity plan for clinical trials
Nature, Published online: 16 February 2023; doi:10.1038/d41586-023-00469-4
US regulatory agency makes ‘big change’ to increase the number of participants from under-represented groups in drug testing.-
Most Recent Articles: Clinical Epigenetics
-
Epigenetic aging in patients diagnosed with coronary artery disease: results of the LipidCardio study
People age biologically at different rates. Epigenetic clock-derived DNA methylation age acceleration (DNAmAA) is among the most promising markers proposed to assess the interindividual differences in biologic...
Epigenetic aging in patients diagnosed with coronary artery disease: results of the LipidCardio study
-
Most Recent Articles: Clinical Epigenetics
-
DNA methylation in human gastric epithelial cells defines regional identity without restricting lineage plasticity
Epigenetic modifications in mammalian DNA are commonly manifested by DNA methylation. In the stomach, altered DNA methylation patterns have been observed following chronic Helicobacter pylori infections and in ga...
DNA methylation in human gastric epithelial cells defines regional identity without restricting lineage plasticity
-
Nature - Issue - nature.com science feeds
-
The co-evolution of the genome and epigenome in colorectal cancer
Nature, Published online: 26 October 2022; doi:10.1038/s41586-022-05202-1A study maps genetic and epigenetic heterogeneity of primary colorectal adenomas and cancers at single-clone resolution through spatial multi-omic profiling of individual glands and adjacent normal tissue.
The co-evolution of the genome and epigenome in colorectal cancer
Nature, Published online: 26 October 2022; doi:10.1038/s41586-022-05202-1
A study maps genetic and epigenetic heterogeneity of primary colorectal adenomas and cancers at single-clone resolution through spatial multi-omic profiling of individual glands and adjacent normal tissue.-
Nature - Issue - nature.com science feeds
-
Phenotypic plasticity and genetic control in colorectal cancer evolution
Nature, Published online: 26 October 2022; doi:10.1038/s41586-022-05311-xIntratumour genetic ancestry only infrequently affects gene expression traits and subclonal evolution in colorectal cancer, with most genetic intratumour variation having no detected phenotypic consequence and transcriptional plasticity being widespread within a tumour.
Phenotypic plasticity and genetic control in colorectal cancer evolution
Nature, Published online: 26 October 2022; doi:10.1038/s41586-022-05311-x
Intratumour genetic ancestry only infrequently affects gene expression traits and subclonal evolution in colorectal cancer, with most genetic intratumour variation having no detected phenotypic consequence and transcriptional plasticity being widespread within a tumour.-
Nature - Issue - nature.com science feeds
-
Billion-dollar US health agency gets new chief — but its direction remains in limbo
Nature, Published online: 12 September 2022; doi:10.1038/d41586-022-02934-yBiologist Renee Wegrzyn will take the reins at ARPA-H as lawmakers battle over its culture and priorities.
Billion-dollar US health agency gets new chief — but its direction remains in limbo
Nature, Published online: 12 September 2022; doi:10.1038/d41586-022-02934-y
Biologist Renee Wegrzyn will take the reins at ARPA-H as lawmakers battle over its culture and priorities.