Most Recent Articles: Clinical Epigenetics
Clinical performance evaluation of a plasma dual-target methylation test for the detection of primary liver cancer: a multicenter study Zhigao Xu · Wanping Chen · Hongsheng Wei · Kui Tan · Lianglu Zhang · Lanlan Dong · Wenjin Liang · Xin Zhou · Tao Zhang · Jian Chen · Chuang Peng · Zhongxin Wang · Shaojun Ye and Qifa Ye
Primary liver cancer (PLC) is a global health concern. The plasma dual-target methylation (PDTM) test, which interrogates the methylation status of GNB4 and Riplet, exhibits a commendable ability to discriminate ...
7 July 2025 at 08:00

Clinical performance evaluation of a plasma dual-target methylation test for the detection of primary liver cancer: a multicenter study

Most Recent Articles: Clinical Epigenetics

By: Zhigao Xu · Wanping Chen · Hongsheng Wei · Kui Tan · Lianglu Zhang · Lanlan Dong · Wenjin Liang · Xin Zhou · Tao Zhang · Jian Chen · Chuang Peng · Zhongxin Wang · Shaojun Ye and Qifa Ye

7 July 2025 at 08:00

Primary liver cancer (PLC) is a global health concern. The plasma dual-target methylation (PDTM) test, which interrogates the methylation status of GNB4 and Riplet, exhibits a commendable ability to discriminate ...

Oncogene - Issue - nature.com science feeds
Using prognostic signatures and machine learning to identify core features associated with response to CDK4/6 inhibitor-based therapy in metastatic breast cancer Agnieszka K. Witkiewicz · Jianxin Wang · Emily Schultz · Thomas N. O’Connor · Tracey O’Connor · Ellis Levine · Erik S. Knudsen
Oncogene, Published online: 26 February 2025; doi:10.1038/s41388-025-03308-0Using prognostic signatures and machine learning to identify core features associated with response to CDK4/6 inhibitor-based therapy in metastatic breast cancer
26 February 2025 at 08:00

Using prognostic signatures and machine learning to identify core features associated with response to CDK4/6 inhibitor-based therapy in metastatic breast cancer

Oncogene - Issue - nature.com science feeds

By: Agnieszka K. Witkiewicz · Jianxin Wang · Emily Schultz · Thomas N. O’Connor · Tracey O’Connor · Ellis Levine · Erik S. Knudsen

26 February 2025 at 08:00

Oncogene, Published online: 26 February 2025; doi:10.1038/s41388-025-03308-0

Using prognostic signatures and machine learning to identify core features associated with response to CDK4/6 inhibitor-based therapy in metastatic breast cancer

Nature - Issue - nature.com science feeds
Reprogramming tumour-associated macrophages to outcompete cancer cells Xian Zhang · Shun Li · Isha Malik · Mytrang H. Do · Liangliang Ji · Chun Chou · Wei Shi · Kristelle J. Capistrano · Jing Zhang · Ting-Wei Hsu · Briana G. Nixon · Ke Xu · Xinxin Wang · Andrea Ballabio · Laura S. Schmidt · W. Marston Linehan · Ming O. Li
Nature, Published online: 28 June 2023; doi:10.1038/s41586-023-06256-5In a mouse model of breast cancer, a low-protein diet induces engulfment activities and mTORC1 signalling in tumour-associated macrophages to suppress engulfment-dependent mTORC1 signalling in MYC-overexpressing cancer cells through cell competition, serving as an innate immune defence mechanism to slow tumour growth.
28 June 2023 at 08:00

Reprogramming tumour-associated macrophages to outcompete cancer cells

Nature - Issue - nature.com science feeds

By: Xian Zhang · Shun Li · Isha Malik · Mytrang H. Do · Liangliang Ji · Chun Chou · Wei Shi · Kristelle J. Capistrano · Jing Zhang · Ting-Wei Hsu · Briana G. Nixon · Ke Xu · Xinxin Wang · Andrea Ballabio · Laura S. Schmidt · W. Marston Linehan · Ming O. Li

28 June 2023 at 08:00

Nature, Published online: 28 June 2023; doi:10.1038/s41586-023-06256-5

In a mouse model of breast cancer, a low-protein diet induces engulfment activities and mTORC1 signalling in tumour-associated macrophages to suppress engulfment-dependent mTORC1 signalling in MYC-overexpressing cancer cells through cell competition, serving as an innate immune defence mechanism to slow tumour growth.

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