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Human interpretable grammar encodes multicellular systems biology models to democratize virtual cell laboratories

We developed a plain text modeling language—a cell behavior hypothesis grammar—to easily build virtual cell models and connect them to data, helping scientists to unlock the hidden dynamics of tissues. We provide examples showing how to use them in virtual experiments exploring how cancer responds to the cells in its environment and how the brain forms layers in development.

Google Gemini: Everything you need to know about the generative AI models

27 February 2025 at 10:09

Gemini is Google’s long-promised, next-gen generative AI model family.

© 2024 TechCrunch. All rights reserved. For personal use only.

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  • OpenAI used this subreddit to test AI persuasion Maxwell Zeff
    OpenAI used the subreddit, r/ChangeMyView, to create a test for measuring the persuasive abilities of its AI reasoning models. The company revealed this in a system card — a document outlining how an AI system works — that was released along with its new “reasoning” model, o3-mini, on Friday. Millions of Reddit users are members […] © 2024 TechCrunch. All rights reserved. For personal use only.
     

OpenAI used this subreddit to test AI persuasion

1 February 2025 at 07:47

OpenAI used the subreddit, r/ChangeMyView, to create a test for measuring the persuasive abilities of its AI reasoning models. The company revealed this in a system card — a document outlining how an AI system works — that was released along with its new “reasoning” model, o3-mini, on Friday. Millions of Reddit users are members […]

© 2024 TechCrunch. All rights reserved. For personal use only.

What Trump 2.0 means for science: the likely winners and losers

Nature, Published online: 15 January 2025; doi:10.1038/d41586-025-00052-z

The incoming US president is expected to gut support for research on the environment and infectious diseases, but could buoy work in artificial intelligence, quantum research and space exploration.

Cancer biomarkers: Emerging trends and clinical implications for personalized treatment

Cancer biomarkers have transformed oncology, enabling treatments tailored to each tumor’s unique profile. This review highlights the field’s progress due to advancements in understanding cancer biology, testing methods, and understanding of the immune microenvironment to advance precision oncology for improved patient outcomes.

Translation of tissue-based artificial intelligence into clinical practice: from discovery to adoption

Oncogene, Published online: 24 October 2023; doi:10.1038/s41388-023-02857-6

Translation of tissue-based artificial intelligence into clinical practice: from discovery to adoption

Histone demethylase KDM5D upregulation drives sex differences in colon cancer

Nature, Published online: 21 June 2023; doi:10.1038/s41586-023-06254-7

A murine colorectal cancer (CRC) model shows that mutant KRAS-STAT4-mediated upregulation of Y chromosome KDM5D contributes to the sex differences in KRAS-mutant CRC, providing an actionable therapeutic strategy for metastasis risk reduction for men afflicted with KRAS-mutant CRC.

Spatial epigenome–transcriptome co-profiling of mammalian tissues

Nature, Published online: 15 March 2023; doi:10.1038/s41586-023-05795-1

The authors present two technologies for spatially resolved, genome-wide, joint profiling of the epigenome and transcriptome by cosequencing chromatin accessibility and gene expression, or histone modifications and gene expression on the same tissue section at near-single-cell resolution.

Epigenetic aging in patients diagnosed with coronary artery disease: results of the LipidCardio study

People age biologically at different rates. Epigenetic clock-derived DNA methylation age acceleration (DNAmAA) is among the most promising markers proposed to assess the interindividual differences in biologic...

DNA methylation in human gastric epithelial cells defines regional identity without restricting lineage plasticity

Epigenetic modifications in mammalian DNA are commonly manifested by DNA methylation. In the stomach, altered DNA methylation patterns have been observed following chronic Helicobacter pylori infections and in ga...
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