arXiv:2510.22998v1 Announce Type: new Abstract: ProfileXAI is a model- and domain-agnostic framework that couples post-hoc explainers (SHAP, LIME, Anchor) with retrieval - augmented LLMs to produce explanations for different types of users. The system indexes a multimodal knowledge base, selects an explainer per instance via quantitative criteria, and generates grounded narratives with chat-enabled prompting. On Heart Disease and Thyroid Cancer datasets, we evaluate fidelity, robustness, parsimony, token use, and perceived quality. No explainer dominates: LIME achieves the best fidelity--robustness trade-off (Infidelity $\le 0.30$, $L

arXiv:2510.23578v1 Announce Type: new Abstract: The rapid adoption of generative artificial intelligence (GenAI) technologies has led many organizations to integrate AI into their products and services, often without considering user preferences. Yet, public attitudes toward AI use, especially in impactful decision-making scenarios, are underexplored. Using a large-scale two-wave survey study (n_wave1=1514, n_wave2=1488) representative of the Swiss population, we examine shifts in public attitudes toward AI before and after the launch of ChatGPT. We find that the GenAI boom is significantly associated with reduced public acceptance of AI (see Figure 1) and increased demand for human oversight in various decision-making contexts. The proportion of respondents finding AI "not acceptable at all" increased from 23% to 30%, while support for human-only decision-making rose from 18% to 26%. These shifts have amplified existing social inequalities in terms of widened educational, linguistic, and gender gaps post-boom. Our findings challenge industry assumptions about public readiness for AI deployment and highlight the critical importance of aligning technological development with evolving public preferences.

arXiv:2510.21810v1 Announce Type: cross Abstract: Diabetic Retinopathy (DR), a vision-threatening complication of Dia-betes Mellitus (DM), is a major global concern, particularly in India, which has one of the highest diabetic populations. Prolonged hyperglycemia damages reti-nal microvasculature, leading to DR symptoms like microaneurysms, hemor-rhages, and fluid leakage, which, if undetected, cause irreversible vision loss. Therefore, early screening is crucial as DR is asymptomatic in its initial stages. Fundus imaging aids precise diagnosis by detecting subtle retinal lesions. This paper introduces a hybrid diagnostic framework combining traditional feature extraction and deep learning (DL) to enhance DR detection. While handcrafted features capture key clinical markers, DL automates hierarchical pattern recog-nition, improving early diagnosis. The model synergizes interpretable clinical data with learned features, surpassing standalone DL approaches that demon-strate superior classification and reduce false negatives. This multimodal AI-driven approach enables scalable, accurate DR screening, crucial for diabetes-burdened regions.

arXiv:2510.22003v1 Announce Type: cross Abstract: Generative AI (GenAI) is reshaping enterprise architecture work in agile software organizations, yet evidence on its effects remains scattered. We report a systematic literature review (SLR), following established SLR protocols of Kitchenham and PRISMA, of 1,697 records, yielding 33 studies across enterprise, solution, domain, business, and IT architect roles. GenAI most consistently supports (i) design ideation and trade-off exploration; (ii) rapid creation and refinement of artifacts (e.g., code, models, documentation); and (iii) architectural decision support and knowledge retrieval. Reported risks include opacity and bias, contextually incorrect outputs leading to rework, privacy and compliance concerns, and social loafing. We also identify emerging skills and competencies, including prompt engineering, model evaluation, and professional oversight, and organizational enablers around readiness and adaptive governance. The review contributes with (1) a mapping of GenAI use cases and risks in agile architecting, (2) implications for capability building and governance, and (3) an initial research agenda on human-AI collaboration in architecture. Overall, the findings inform responsible adoption of GenAI that accelerates digital transformation while safeguarding architectural integrity.

arXiv:2510.22206v1 Announce Type: cross Abstract: Execution algorithms are vital to modern trading, they enable market participants to execute large orders while minimising market impact and transaction costs. As these algorithms grow more sophisticated, optimising them becomes increasingly challenging. In this work, we present a reinforcement learning (RL) framework for discovering optimal execution strategies, evaluated within a reactive agent-based market simulator. This simulator creates reactive order flow and allows us to decompose slippage into its constituent components: market impact and execution risk. We assess the RL agent's performance using the efficient frontier based on work by Almgren and Chriss, measuring its ability to balance risk and cost. Results show that the RL-derived strategies consistently outperform baselines and operate near the efficient frontier, demonstrating a strong ability to optimise for risk and impact. These findings highlight the potential of reinforcement learning as a powerful tool in the trader's toolkit.

arXiv:2510.22620v1 Announce Type: cross Abstract: AI agents powered by large language models (LLMs) are being deployed at scale, yet we lack a systematic understanding of how the choice of backbone LLM affects agent security. The non-deterministic sequential nature of AI agents complicates security modeling, while the integration of traditional software with AI components entangles novel LLM vulnerabilities with conventional security risks. Existing frameworks only partially address these challenges as they either capture specific vulnerabilities only or require modeling of complete agents. To address these limitations, we introduce threat snapshots: a framework that isolates specific states in an agent's execution flow where LLM vulnerabilities manifest, enabling the systematic identification and categorization of security risks that propagate from the LLM to the agent level. We apply this framework to construct the $\operatorname{b}^3$ benchmark, a security benchmark based on 194331 unique crowdsourced adversarial attacks. We then evaluate 31 popular LLMs with it, revealing, among other insights, that enhanced reasoning capabilities improve security, while model size does not correlate with security. We release our benchmark, dataset, and evaluation code to facilitate widespread adoption by LLM providers and practitioners, offering guidance for agent developers and incentivizing model developers to prioritize backbone security improvements.

arXiv:2508.02630v2 Announce Type: replace Abstract: Online marketplaces will be transformed by autonomous AI agents acting on behalf of consumers. Rather than humans browsing and clicking, AI agents can parse webpages or interact through APIs to evaluate products, and transact. This raises a fundamental question: what do AI agents buy-and why? We develop ACES, a sandbox environment that pairs a platform-agnostic agent with a fully programmable mock marketplace to study this. We first explore aggregate choices, revealing that modal choices can differ across models, with AI agents sometimes concentrating on a few products, raising competition questions. We then analyze the drivers of choices through rationality checks and randomized experiments on product positions and listing attributes. Models show sizeable and heterogeneous position effects: all favor the top row, yet different models prefer different columns, undermining the assumption of a universal ``top'' rank. They penalize sponsored tags, reward endorsements, and sensitivities to price, ratings, and reviews are directionally as expected, but vary sharply across models. Finally, we find that a seller-side agent that makes minor tweaks to product descriptions can deliver substantial market-share gains by targeting AI buyer preferences. Our findings reveal how AI agents behave in e-commerce, and surface concrete seller strategy, platform design, and regulatory questions.

arXiv:2507.22030v2 Announce Type: replace-cross Abstract: We introduce ReXGroundingCT, the first publicly available dataset linking free-text findings to pixel-level 3D segmentations in chest CT scans. The dataset includes 3,142 non-contrast chest CT scans paired with standardized radiology reports from CT-RATE. Construction followed a structured three-stage pipeline. First, GPT-4 was used to extract and standardize findings, descriptors, and metadata from reports originally written in Turkish and machine-translated into English. Second, GPT-4o-mini categorized each finding into a hierarchical ontology of lung and pleural abnormalities. Third, 3D annotations were produced for all CT volumes: the training set was quality-assured by board-certified radiologists, and the validation and test sets were fully annotated by board-certified radiologists. Additionally, a complementary chain-of-thought dataset was created to provide step-by-step hierarchical anatomical reasoning for localizing findings within the CT volume, using GPT-4o and localization coordinates derived from organ segmentation models. ReXGroundingCT contains 16,301 annotated entities across 8,028 text-to-3D-segmentation pairs, covering diverse radiological patterns from 3,142 non-contrast CT scans. About 79% of findings are focal abnormalities and 21% are non-focal. The dataset includes a public validation set of 50 cases and a private test set of 100 cases, both annotated by board-certified radiologists. The dataset establishes a foundation for enabling free-text finding segmentation and grounded radiology report generation in CT imaging. Model performance on the private test set is hosted on a public leaderboard at https://rexrank.ai/ReXGroundingCT. The dataset is available at https://huggingface.co/datasets/rajpurkarlab/ReXGroundingCT.

The RAG paradigm redefines AI: it combines generative models and business data for accurate, contextualised responses. The article shows how to integrate Spring Boot, Spring AI, MongoDB Atlas and OpenAI into a powerful and flexible pipeline capable of transforming the way businesses access and create value from data, with applications ranging from finance and healthcare to customer service.

By Matteo Rossi

npj Digital Medicine, Published online: 27 October 2025; doi:10.1038/s41746-025-01996-2

Benchmarking large language models for personalized, biomarker-based health intervention recommendations

arXiv:2510.21027v1 Announce Type: new Abstract: Harmonizing medication data across Electronic Health Record (EHR) systems is a persistent barrier to monitoring medications for opioid use disorder (MOUD). In heterogeneous EHR systems, key prescription attributes are scattered across differently formatted fields and freetext notes. We present a practical framework that customizes open source large language models (LLMs), including Llama, Qwen, Gemma, and MedGemma, to extract a unified set of MOUD prescription attributes (prescription date, drug name, duration, total quantity, daily quantity, and refills) from heterogeneous, site specific data and compute a standardized metric of medication coverage, \emph{MOUD days}, per patient. Our pipeline processes records directly in a fixed JSON schema, followed by lightweight normalization and cross-field consistency checks. We evaluate the system on prescription level EHR data from five clinics in a national OUD study (25{,}605 records from 1{,}257 patients), using a previously annotated benchmark of 10{,}369 records (776 patients) as the ground truth. Performance is reported as coverage (share of records with a valid, matchable output) and record-level exact-match accuracy. Larger models perform best overall: Qwen2.5-32B achieves \textbf{93.4\%} coverage with \textbf{93.0\%} exact-match accuracy across clinics, and MedGemma-27B attains \textbf{93.1\%}/\textbf{92.2\%}. A brief error review highlights three common issues and fixes: imputing missing dosage fields using within-drug norms, handling monthly/weekly injectables (e.g., Vivitrol) by setting duration from the documented schedule, and adding unit checks to prevent mass units (e.g., ``250 g'') from being misread as daily counts. By removing brittle, site-specific ETL and supporting local, privacy-preserving deployment, this approach enables consistent cross-site analyses of MOUD exposure, adherence, and retention in real-world settings.

arXiv:2510.21285v1 Announce Type: new Abstract: Large Reasoning Models (LRMs) demonstrate remarkable capabilities on complex reasoning tasks but remain vulnerable to severe safety risks, including harmful content generation and jailbreak attacks. Existing mitigation strategies rely on injecting heuristic safety signals during training, which often suppress reasoning ability and fail to resolve the safety-reasoning trade-off. To systematically investigate this issue, we analyze the reasoning trajectories of diverse LRMs and uncover a phenomenon we term Self-Jailbreak, where models override their own risk assessments and justify responding to unsafe prompts. This finding reveals that LRMs inherently possess the ability to reject unsafe queries, but this ability is compromised, resulting in harmful outputs. Building on these insights, we propose the Chain-of-Guardrail (CoG), a training framework that recomposes or backtracks unsafe reasoning steps, steering the model back onto safe trajectories while preserving valid reasoning chains. Extensive experiments across multiple reasoning and safety benchmarks demonstrate that CoG substantially improves the safety of current LRMs while preserving comparable reasoning ability, significantly outperforming prior methods that suffer from severe safety-reasoning trade-offs.

arXiv:2510.21293v1 Announce Type: new Abstract: Background: Trustworthy AI serves as a foundational pillar for two major AI ethics conferences: AIES and FAccT. However, current research often adopts techno-centric approaches, focusing primarily on technical attributes such as reliability, robustness, and fairness, while overlooking the sociotechnical dimensions critical to understanding AI trustworthiness in real-world contexts. Objectives: This scoping review aims to examine how the AIES and FAccT communities conceptualize, measure, and validate AI trustworthiness, identifying major gaps and opportunities for advancing a holistic understanding of trustworthy AI systems. Methods: We conduct a scoping review of AIES and FAccT conference proceedings to date, systematically analyzing how trustworthiness is defined, operationalized, and applied across different research domains. Our analysis focuses on conceptualization approaches, measurement methods, verification and validation techniques, application areas, and underlying values. Results: While significant progress has been made in defining technical attributes such as transparency, accountability, and robustness, our findings reveal critical gaps. Current research often predominantly emphasizes technical precision at the expense of social and ethical considerations. The sociotechnical nature of AI systems remains less explored and trustworthiness emerges as a contested concept shaped by those with the power to define it. Conclusions: An interdisciplinary approach combining technical rigor with social, cultural, and institutional considerations is essential for advancing trustworthy AI. We propose actionable measures for the AI ethics community to adopt holistic frameworks that genuinely address the complex interplay between AI systems and society, ultimately promoting responsible technological development that benefits all stakeholders.

arXiv:2510.21436v1 Announce Type: new Abstract: This study presents AutoOpt-11k, a unique image dataset of over 11,000 handwritten and printed mathematical optimization models corresponding to single-objective, multi-objective, multi-level, and stochastic optimization problems exhibiting various types of complexities such as non-linearity, non-convexity, non-differentiability, discontinuity, and high-dimensionality. The labels consist of the LaTeX representation for all the images and modeling language representation for a subset of images. The dataset is created by 25 experts following ethical data creation guidelines and verified in two-phases to avoid errors. Further, we develop AutoOpt framework, a machine learning based automated approach for solving optimization problems, where the user just needs to provide an image of the formulation and AutoOpt solves it efficiently without any further human intervention. AutoOpt framework consists of three Modules: (i) M1 (Image_to_Text)- a deep learning model performs the Mathematical Expression Recognition (MER) task to generate the LaTeX code corresponding to the optimization formulation in image; (ii) M2 (Text_to_Text)- a small-scale fine-tuned LLM generates the PYOMO script (optimization modeling language) from LaTeX code; (iii) M3 (Optimization)- a Bilevel Optimization based Decomposition (BOBD) method solves the optimization formulation described in the PYOMO script. We use AutoOpt-11k dataset for training and testing of deep learning models employed in AutoOpt. The deep learning model for MER task (M1) outperforms ChatGPT, Gemini and Nougat on BLEU score metric. BOBD method (M3), which is a hybrid approach, yields better results on complex test problems compared to common approaches, like interior-point algorithm and genetic algorithm.

arXiv:2510.21652v1 Announce Type: new Abstract: AI agents hold the potential to revolutionize scientific productivity by automating literature reviews, replicating experiments, analyzing data, and even proposing new directions of inquiry; indeed, there are now many such agents, ranging from general-purpose "deep research" systems to specialized science-specific agents, such as AI Scientist and AIGS. Rigorous evaluation of these agents is critical for progress. Yet existing benchmarks fall short on several fronts: they (1) fail to provide holistic, product-informed measures of real-world use cases such as science research; (2) lack reproducible agent tools necessary for a controlled comparison of core agentic capabilities; (3) do not account for confounding variables such as model cost and tool access; (4) do not provide standardized interfaces for quick agent prototyping and evaluation; and (5) lack comprehensive baseline agents necessary to identify true advances. In response, we define principles and tooling for more rigorously benchmarking agents. Using these, we present AstaBench, a suite that provides the first holistic measure of agentic ability to perform scientific research, comprising 2400+ problems spanning the entire scientific discovery process and multiple scientific domains, and including many problems inspired by actual user requests to deployed Asta agents. Our suite comes with the first scientific research environment with production-grade search tools that enable controlled, reproducible evaluation, better accounting for confounders. Alongside, we provide a comprehensive suite of nine science-optimized classes of Asta agents and numerous baselines. Our extensive evaluation of 57 agents across 22 agent classes reveals several interesting findings, most importantly that despite meaningful progress on certain individual aspects, AI remains far from solving the challenge of science research assistance.

arXiv:2510.18212v2 Announce Type: replace Abstract: The lack of a concrete definition for Artificial General Intelligence (AGI) obscures the gap between today's specialized AI and human-level cognition. This paper introduces a quantifiable framework to address this, defining AGI as matching the cognitive versatility and proficiency of a well-educated adult. To operationalize this, we ground our methodology in Cattell-Horn-Carroll theory, the most empirically validated model of human cognition. The framework dissects general intelligence into ten core cognitive domains-including reasoning, memory, and perception-and adapts established human psychometric batteries to evaluate AI systems. Application of this framework reveals a highly "jagged" cognitive profile in contemporary models. While proficient in knowledge-intensive domains, current AI systems have critical deficits in foundational cognitive machinery, particularly long-term memory storage. The resulting AGI scores (e.g., GPT-4 at 27%, GPT-5 at 57%) concretely quantify both rapid progress and the substantial gap remaining before AGI.

Background: The adoption of new technologies and data modernization approaches in public health aims to enhance the use of health data to inform decision-making and improve population health. However, public health departments struggle with legacy systems, siloed data, and privacy concerns, hampering new technology adoption and data sharing with stakeholders. This paper maps how to address these shortcomings by identifying data modernization challenges, initiatives, and progress. Objective: To characterize the evidence for data modernization associated gaps and best practices in public health. Methods: This scoping review was conducted using the five-stage framework developed by Arksey and O’Malley and was reported according to the PRISMA-ScR guidelines. A structured search was performed in databases PubMed, Scopus, CINAHL, PsycINFO, and was complemented by a further search in the Google Scholar search engine, covering publications from January 1, 2019, to April 30, 2024. Eligible studies were peer-reviewed, published in English, and focused on data modernization initiatives within U.S. public health and reported on best practices, challenges, and outcomes. Search terms combined concepts such as “Data Modernization,” “Interoperability,” and “Public Health” using Boolean operators. Two reviewers independently screened titles, abstracts, and full texts using Rayyan QCRI, with conflicts resolved through consultation with a third reviewer. Data was extracted into Microsoft Excel and thematically analyzed. Results: This review analyzed 22 studies focused on public health data modernization. Across the literature, common components included transitioning to cloud-based systems, consolidating fragmented data into unified platforms, applying governance frameworks, and implementing analytics tools to support decision-making. Primary data sources were electronic health records, insurance claims, and disease surveillance registries. Key challenges identified across studies involved data quality issues, lack of interoperability, and limited resources, particularly in underfunded settings. Notable benefits included more timely and accessible data, improved integration across systems, and enhanced analytical capabilities, which collectively support more responsive and effective public health interventions when guided by clear standards and policy alignment. Conclusions: Progress hinges on balancing local adaptability with national coordination, improving data governance practices, and enhancing collaboration across institutions. These steps are vital to ensure public health systems can deliver timely, accurate, and actionable information to support effective public health efforts.

arXiv:2510.20568v1 Announce Type: new Abstract: The worlds people have strong opinions about artificial intelligence (AI), and they want policymakers to listen. Governments are inviting public comment on AI, but as they translate input into policy, much of what citizens say is lost. Policymakers are missing a critical opportunity to build trust in AI and its governance. This paper compares three countries, Australia, Colombia, and the United States, that invited citizens to comment on AI risks and policies. Using a landscape analysis, the authors examined how each government solicited feedback and whether that input shaped governance. Yet in none of the three cases did citizens and policymakers establish a meaningful dialogue. Governments did little to attract diverse voices or publicize calls for comment, leaving most citizens unaware or unprepared to respond. In each nation, fewer than one percent of the population participated. Moreover, officials showed limited responsiveness to the feedback they received, failing to create an effective feedback loop. The study finds a persistent gap between the promise and practice of participatory AI governance. The authors conclude that current approaches are unlikely to build trust or legitimacy in AI because policymakers are not adequately listening or responding to public concerns. They offer eight recommendations: promote AI literacy; monitor public feedback; broaden outreach; hold regular online forums; use innovative engagement methods; include underrepresented groups; respond publicly to input; and make participation easier.

arXiv:2510.20721v1 Announce Type: cross Abstract: Large language models (LLMs) have seen rapid adoption for tasks such as drafting emails, summarizing meetings, and answering health questions. In such uses, users may need to share private information (e.g., health records, contact details). To evaluate LLMs' ability to identify and redact such private information, prior work developed benchmarks (e.g., ConfAIde, PrivacyLens) with real-life scenarios. Using these benchmarks, researchers have found that LLMs sometimes fail to keep secrets private when responding to complex tasks (e.g., leaking employee salaries in meeting summaries). However, these evaluations rely on LLMs (proxy LLMs) to gauge compliance with privacy norms, overlooking real users' perceptions. Moreover, prior work primarily focused on the privacy-preservation quality of responses, without investigating nuanced differences in helpfulness. To understand how users perceive the privacy-preservation quality and helpfulness of LLM responses to privacy-sensitive scenarios, we conducted a user study with 94 participants using 90 scenarios from PrivacyLens. We found that, when evaluating identical responses to the same scenario, users showed low agreement with each other on the privacy-preservation quality and helpfulness of the LLM response. Further, we found high agreement among five proxy LLMs, while each individual LLM had low correlation with users' evaluations. These results indicate that the privacy and helpfulness of LLM responses are often specific to individuals, and proxy LLMs are poor estimates of how real users would perceive these responses in privacy-sensitive scenarios. Our results suggest the need to conduct user-centered studies on measuring LLMs' ability to help users while preserving privacy. Additionally, future research could investigate ways to improve the alignment between proxy LLMs and users for better estimation of users' perceived privacy and utility.

arXiv:2510.16206v2 Announce Type: replace Abstract: Since the rapid expansion of large language models (LLMs), people have begun to rely on them for information retrieval. While traditional search engines display ranked lists of sources shaped by search engine optimization (SEO), advertising, and personalization, LLMs typically provide a synthesized response that feels singular and authoritative. While both approaches carry risks of bias and omission, LLMs may amplify the effect by collapsing multiple perspectives into one answer, reducing users ability or inclination to compare alternatives. This concentrates power over information in a few LLM vendors whose systems effectively shape what is remembered and what is overlooked. As a result, certain narratives, individuals or groups, may be disproportionately suppressed, while others are disproportionately elevated. Over time, this creates a new threat: the gradual erasure of those with limited digital presence, and the amplification of those already prominent, reshaping collective memory. To address these concerns, this paper presents a concept of the Right To Be Remembered (RTBR) which encompasses minimizing the risk of AI-driven information omission, embracing the right of fair treatment, while ensuring that the generated content would be maximally truthful.