Normal view
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cs.AI, q-bio.NC updates on arXiv.org
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CACARA: Cross-Modal Alignment Leveraging a Text-Centric Approach for Cost-Effective Multimodal and Multilingual Learning
arXiv:2512.00496v1 Announce Type: cross Abstract: As deep learning models evolve, new applications and challenges are rapidly emerging. Tasks that once relied on a single modality, such as text, images, or audio, are now enriched by seamless interactions between multimodal data. These connections bridge information gaps: an image can visually materialize a text, while audio can add context to an image. Researchers have developed numerous multimodal models, but most rely on resource-intensive tr
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cs.AI, q-bio.NC updates on arXiv.org
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Slovak Conceptual Dictionary
arXiv:2512.00579v1 Announce Type: cross Abstract: When solving tasks in the field of natural language processing, we sometimes need dictionary tools, such as lexicons, word form dictionaries or knowledge bases. However, the availability of dictionary data is insufficient in many languages, especially in the case of low resourced languages. In this article, we introduce a new conceptual dictionary for the Slovak language as the first linguistic tool of this kind. Since Slovak language is a langu
Slovak Conceptual Dictionary
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cs.AI, q-bio.NC updates on arXiv.org
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Wikontic: Constructing Wikidata-Aligned, Ontology-Aware Knowledge Graphs with Large Language Models
arXiv:2512.00590v1 Announce Type: cross Abstract: Knowledge graphs (KGs) provide structured, verifiable grounding for large language models (LLMs), but current LLM-based systems commonly use KGs as auxiliary structures for text retrieval, leaving their intrinsic quality underexplored. In this work, we propose Wikontic, a multi-stage pipeline that constructs KGs from open-domain text by extracting candidate triplets with qualifiers, enforcing Wikidata-based type and relation constraints, and nor
Wikontic: Constructing Wikidata-Aligned, Ontology-Aware Knowledge Graphs with Large Language Models
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cs.AI, q-bio.NC updates on arXiv.org
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Deep Learning-Based Computer Vision Models for Early Cancer Detection Using Multimodal Medical Imaging and Radiogenomic Integration Frameworks
arXiv:2512.00714v1 Announce Type: cross Abstract: Early cancer detection remains one of the most critical challenges in modern healthcare, where delayed diagnosis significantly reduces survival outcomes. Recent advancements in artificial intelligence, particularly deep learning, have enabled transformative progress in medical imaging analysis. Deep learning-based computer vision models, such as convolutional neural networks (CNNs), transformers, and hybrid attention architectures, can automatic
Deep Learning-Based Computer Vision Models for Early Cancer Detection Using Multimodal Medical Imaging and Radiogenomic Integration Frameworks
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cs.AI, q-bio.NC updates on arXiv.org
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Multi-Modal AI for Remote Patient Monitoring in Cancer Care
arXiv:2512.00949v1 Announce Type: cross Abstract: For patients undergoing systemic cancer therapy, the time between clinic visits is full of uncertainties and risks of unmonitored side effects. To bridge this gap in care, we developed and prospectively trialed a multi-modal AI framework for remote patient monitoring (RPM). This system integrates multi-modal data from the HALO-X platform, such as demographics, wearable sensors, daily surveys, and clinical events. Our observational trial is one o
Multi-Modal AI for Remote Patient Monitoring in Cancer Care
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cs.AI, q-bio.NC updates on arXiv.org
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Will Humanity Be Rendered Obsolete by AI?
arXiv:2510.22814v3 Announce Type: replace Abstract: This article analyzes the existential risks artificial intelligence (AI) poses to humanity, tracing the trajectory from current AI to ultraintelligence. Drawing on Irving J. Good and Nick Bostrom's theoretical work, plus recent publications (AI 2027; If Anyone Builds It, Everyone Dies), it explores AGI and superintelligence. Considering machines' exponentially growing cognitive power and hypothetical IQs, it addresses the ethical and existenti
Will Humanity Be Rendered Obsolete by AI?
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cs.AI, q-bio.NC updates on arXiv.org
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Life-Code: Central Dogma Modeling with Multi-Omics Sequence Unification
arXiv:2502.07299v3 Announce Type: replace-cross Abstract: The interactions between DNA, RNA, and proteins are fundamental to biological processes, as illustrated by the central dogma of molecular biology. Although modern biological pre-trained models have achieved great success in analyzing these macromolecules individually, their interconnected nature remains underexplored. This paper follows the guidance of the central dogma to redesign both the data and model pipeline and offers a comprehens
Life-Code: Central Dogma Modeling with Multi-Omics Sequence Unification
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cs.AI, q-bio.NC updates on arXiv.org
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The AI Productivity Index (APEX)
arXiv:2509.25721v3 Announce Type: replace-cross Abstract: We present an extended version of the AI Productivity Index (APEX-v1-extended), a benchmark for assessing whether frontier models are capable of performing economically valuable tasks in four jobs: investment banking associate, management consultant, big law associate, and primary care physician (MD). This technical report details the extensions to APEX-v1, including an increase in the held-out evaluation set from n = 50 to n = 100 cases
The AI Productivity Index (APEX)
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STAT

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Opinion: Racial bias in medicine can be as simple as dismissing Black patients as a ‘hard stick’
I was moments away from a routine screening colonoscopy when it happened again. The warm and professional pre-procedure nurse began preparing for intravenous insertion. She tied the tourniquet loosely around my arm, took a quick glance, and untied it within seconds. “I can’t find a vein. You must be dehydrated,” she said, moving immediately to the back of my hand. I paused. I didn’t feel dehydrated. Yes, I had followed the bowel prep instructions, consuming only liquids the day before, but I
Opinion: Racial bias in medicine can be as simple as dismissing Black patients as a ‘hard stick’
I was moments away from a routine screening colonoscopy when it happened again. The warm and professional pre-procedure nurse began preparing for intravenous insertion. She tied the tourniquet loosely around my arm, took a quick glance, and untied it within seconds. “I can’t find a vein. You must be dehydrated,” she said, moving immediately to the back of my hand.
I paused. I didn’t feel dehydrated. Yes, I had followed the bowel prep instructions, consuming only liquids the day before, but I had no signs of dehydration. I knew my body. I knew my veins.


© AIZAR RALDES/AFP via Getty Images
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npj Digital Medicine
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The role of digital twins in P4 medicine: A paradigm for modern healthcare
npj Digital Medicine, Published online: 01 December 2025; doi:10.1038/s41746-025-02115-xThe role of digital twins in P4 medicine: A paradigm for modern healthcare
The role of digital twins in P4 medicine: A paradigm for modern healthcare
npj Digital Medicine, Published online: 01 December 2025; doi:10.1038/s41746-025-02115-x
The role of digital twins in P4 medicine: A paradigm for modern healthcare-
MRD
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DNA-Based Liquid Biopsy for Evaluating Surgical and Postsurgical Outcomes in Gynecologic Malignancies: A Systematic Review
J Clin Lab Anal. 2025 Dec 1:e70139. doi: 10.1002/jcla.70139. Online ahead of print.ABSTRACTINTRODUCTION: DNA-based liquid biopsies, including circulating tumor DNA (ctDNA) and cell-free DNA (cfDNA), are emerging as minimally invasive biomarkers for monitoring surgical and postsurgical outcomes in gynecologic malignancies. These tools offer the potential to guide early intervention, refine risk stratification, and improve prognostic accuracy. This systematic review aimed to assess the clinical ut
DNA-Based Liquid Biopsy for Evaluating Surgical and Postsurgical Outcomes in Gynecologic Malignancies: A Systematic Review
J Clin Lab Anal. 2025 Dec 1:e70139. doi: 10.1002/jcla.70139. Online ahead of print.
ABSTRACT
INTRODUCTION: DNA-based liquid biopsies, including circulating tumor DNA (ctDNA) and cell-free DNA (cfDNA), are emerging as minimally invasive biomarkers for monitoring surgical and postsurgical outcomes in gynecologic malignancies. These tools offer the potential to guide early intervention, refine risk stratification, and improve prognostic accuracy. This systematic review aimed to assess the clinical utility of DNA-based liquid biopsies in evaluating recurrence, surgical success, and preoperative diagnosis in gynecologic cancers.
METHODS: A systematic review was conducted in accordance with PRISMA guidelines, covering studies published from 2017 to 2025. Literature searches were performed in PubMed, Scopus, and Web of Science. A total of 32 eligible observational studies involving 3210 patients with ovarian, endometrial, uterine, and other gynecologic malignancies were included. Study quality was assessed using the Newcastle-Ottawa Scale (NOS).
RESULTS: The studies showed a broad geographic and methodological diversity, with a median NOS score of 7. CtDNA and cfDNA demonstrated promise in three key areas: (1) Recurrence prediction-postoperative ctDNA positivity was associated with higher relapse rates and reduced disease-free survival; (2) Monitoring surgical outcomes and treatment response-ctDNA dynamics more accurately reflected tumor burden than traditional markers like CA125; (3) Preoperative diagnostic support-cfDNA methylation profiling and cfDNA/CA125 models enhanced malignancy detection and risk stratification. Ovarian and endometrial cancers were most frequently studied.
CONCLUSIONS: DNA-based liquid biopsies show strong potential in perioperative care for gynecologic cancers. Their integration into clinical workflows could improve the detection of minimal residual disease and inform individualized surgical planning.
PMID:41327898 | DOI:10.1002/jcla.70139
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Journal of Medical Internet Research
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Acceptability of Health Information Technology by Health Care Professionals: Where We Are Now and How We Can Fill the Gap
Digital health is expected to improve efficiency and quality of health. Health information technologies (HIT) imply allocated time, appropriate training and new types of responsibility whose physical and mental impact on healthcare professionals (HCPs) has emerged as an important issue. The present review provides updated data and opinions about such potential impact and discusses the relevance of ongoing programs established to better characterize barriers and facilitators of HIT implementation
Acceptability of Health Information Technology by Health Care Professionals: Where We Are Now and How We Can Fill the Gap
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Journal of Medical Internet Research
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AI-Enhanced Social Robotic Versus Computer-Based Virtual Patients for Clinical Reasoning Training in Medical Education: Observational Crossover Cohort Study
Background: Virtual patient (VP) simulations can be used to practice clinical reasoning (CR) in controlled learning environments. Traditional computer-based VP platforms often lack the authenticity and interactivity required for effective CR training. Artificial intelligence (AI)–enhanced social robotic VPs can enhance realism and engagement; however, quantitative evidence comparing them with conventional VP platforms remains limited. Objective: We compared medical students’ experience of an AI-
AI-Enhanced Social Robotic Versus Computer-Based Virtual Patients for Clinical Reasoning Training in Medical Education: Observational Crossover Cohort Study
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MRD
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Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer
Mol Oncol. 2025 Nov 27. doi: 10.1002/1878-0261.70170. Online ahead of print.ABSTRACTBreast cancer is known for late recurrences, yet current follow-up lacks radiological or blood-based monitoring for systemic relapse. This study evaluated circulating tumor DNA (ctDNA) monitoring for early detection of systemic relapse after curative treatment. In this case-control study of 70 patients with operable breast cancer (35 with relapse and 35 without relapse), blood samples were collected every 6-12 mo
Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer
Mol Oncol. 2025 Nov 27. doi: 10.1002/1878-0261.70170. Online ahead of print.
ABSTRACT
Breast cancer is known for late recurrences, yet current follow-up lacks radiological or blood-based monitoring for systemic relapse. This study evaluated circulating tumor DNA (ctDNA) monitoring for early detection of systemic relapse after curative treatment. In this case-control study of 70 patients with operable breast cancer (35 with relapse and 35 without relapse), blood samples were collected every 6-12 months during a median 8.3-year follow-up. ctDNA was analyzed by targeted DNA sequencing using Oncomine™ Breast cfDNA Research Assay v2, and results were compared to genetic analysis of tumor and metastasis biopsies. ctDNA was detected at relapse in 19 of 35 (54%) patients with disease relapse and preceded clinical or radiological relapse detection in 17, with a median lead time of 10.3 months. In 13 (68%) patients, there was concordance with tumor mutations, and in seven patients, there was also concordance with metastasis. Among the relapse-free patients, seven were ctDNA-positive postsurgery, and only one of them had a match among the tumor variants. These findings suggest serial ctDNA analysis may enable earlier detection of systemic relapse in patients with operable breast cancer.
PMID:41307327 | DOI:10.1002/1878-0261.70170
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npj Digital Medicine
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Research progress in computer-aided diagnosis systems for lung cancer
npj Digital Medicine, Published online: 26 November 2025; doi:10.1038/s41746-025-02101-3Research progress in computer-aided diagnosis systems for lung cancer
Research progress in computer-aided diagnosis systems for lung cancer
npj Digital Medicine, Published online: 26 November 2025; doi:10.1038/s41746-025-02101-3
Research progress in computer-aided diagnosis systems for lung cancer-
cs.AI, q-bio.NC updates on arXiv.org
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Cognitive bias in LLM reasoning compromises interpretation of clinical oncology notes
arXiv:2511.20680v1 Announce Type: cross Abstract: Despite high performance on clinical benchmarks, large language models may reach correct conclusions through faulty reasoning, a failure mode with safety implications for oncology decision support that is not captured by accuracy-based evaluation. In this two-cohort retrospective study, we developed a hierarchical taxonomy of reasoning errors from GPT-4 chain-of-thought responses to real oncology notes and tested its clinical relevance. Using br
Cognitive bias in LLM reasoning compromises interpretation of clinical oncology notes
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cs.AI, q-bio.NC updates on arXiv.org
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Rigor in AI: Doing Rigorous AI Work Requires a Broader, Responsible AI-Informed Conception of Rigor
arXiv:2506.14652v2 Announce Type: replace-cross Abstract: In AI research and practice, rigor remains largely understood in terms of methodological rigor -- such as whether mathematical, statistical, or computational methods are correctly applied. We argue that this narrow conception of rigor has contributed to the concerns raised by the responsible AI community, including overblown claims about the capabilities of AI systems. Our position is that a broader conception of what rigorous AI researc
Rigor in AI: Doing Rigorous AI Work Requires a Broader, Responsible AI-Informed Conception of Rigor
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(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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Smart spatial omics (S2-omics) optimizes region of interest selection to capture molecular heterogeneity in diverse tissues
Nat Cell Biol. 2025 Nov 26. doi: 10.1038/s41556-025-01811-w. Online ahead of print.ABSTRACTSpatial omics technologies have transformed biomedical research by enabling high-resolution molecular profiling while preserving the native tissue architecture. These advances provide unprecedented insights into tissue structure and function. However, the high cost and time-intensive nature of spatial omics experiments necessitate careful experimental design, particularly in selecting regions of interest (
Smart spatial omics (S2-omics) optimizes region of interest selection to capture molecular heterogeneity in diverse tissues
Nat Cell Biol. 2025 Nov 26. doi: 10.1038/s41556-025-01811-w. Online ahead of print.
ABSTRACT
Spatial omics technologies have transformed biomedical research by enabling high-resolution molecular profiling while preserving the native tissue architecture. These advances provide unprecedented insights into tissue structure and function. However, the high cost and time-intensive nature of spatial omics experiments necessitate careful experimental design, particularly in selecting regions of interest (ROIs) from large tissue sections. Currently, ROI selection is performed manually, which introduces subjectivity, inconsistency and a lack of reproducibility. Previous studies have shown strong correlations between spatial molecular patterns and histological features, suggesting that readily available and cost-effective histology images can be leveraged to guide spatial omics experiments. Here we present Smart Spatial omics (S2-omics), an end-to-end workflow that automatically selects ROIs from histology images with the goal of maximizing molecular information content in the ROIs. Through comprehensive evaluations across multiple spatial omics platforms and tissue types, we demonstrate that S2-omics enables systematic and reproducible ROI selection and enhances the robustness and impact of downstream biological discovery.
PMID:41298871 | DOI:10.1038/s41556-025-01811-w
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npj Digital Medicine
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Information content as a health system screening tool for rare diseases
npj Digital Medicine, Published online: 25 November 2025; doi:10.1038/s41746-025-02096-xInformation content as a health system screening tool for rare diseases
Information content as a health system screening tool for rare diseases
npj Digital Medicine, Published online: 25 November 2025; doi:10.1038/s41746-025-02096-x
Information content as a health system screening tool for rare diseases-
cs.AI, q-bio.NC updates on arXiv.org
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Toward explainable AI approaches for breast imaging: adapting foundation models to diverse populations
arXiv:2511.17828v1 Announce Type: cross Abstract: Foundation models hold promise for specialized medical imaging tasks, though their effectiveness in breast imaging remains underexplored. This study leverages BiomedCLIP as a foundation model to address challenges in model generalization. BiomedCLIP was adapted for automated BI-RADS breast density classification using multi-modality mammographic data (synthesized 2D images, digital mammography, and digital breast tomosynthesis). Using 96,995 ima