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Normal view

Synthesis of portimines reveals the basis of their anti-cancer activity

Nature, Published online: 20 September 2023; doi:10.1038/s41586-023-06535-1

A scalable total synthesis of portimines enables structural reassignment of portimine B and in-depth functional evaluation of portimine A, revealing that portimine A induces translation inhibition selectively in human cancer cells and is efficacious in vivo tumour-clearance models.

Scientific discovery in the age of artificial intelligence

Nature, Published online: 02 August 2023; doi:10.1038/s41586-023-06221-2

The advances in artificial intelligence over the past decade are examined, with a discussion on how artificial intelligence systems can aid the scientific process and the central issues that remain despite advances.

Epigenetically regulated gene expression profiles decipher four molecular subtypes with prognostic and therapeutic implications in gastric cancer

Gastric cancer (GC) is one of the most common malignant tumors of the digestive tract which seriously endangers the health of human beings worldwide. Transcriptomic deregulation by epigenetic mechanisms plays ...

Predicting disease-free survival in colorectal cancer by circulating tumor DNA methylation markers

Recurrence represents a well-known poor prognostic factor for colorectal cancer (CRC) patients. This study aimed to establish an effective prognostic prediction model based on noninvasive circulating tumor DNA...
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