Nature, Published online: 08 May 2024; doi:10.1038/s41586-024-07370-8
Enhanced light–molecule interactions in high-finesse fibre-based Fabry–Pérot microcavities are used to detect and profile individual unlabelled solution-phase biomolecules, leading to potential applications in the life and chemical sciences.
Nature, Published online: 01 May 2024; doi:10.1038/s41586-024-07359-3
Quantitative multimodal 3D reconstruction of human pancreatic tissue at single-cell resolution reveals a high burden of multifocal, genetically heterogeneous pancreatic intraepithelial neoplasias in the normal adult pancreas.
Cell Death Discovery, Published online: 30 April 2024; doi:10.1038/s41420-024-01883-x
Molecular profiling of a bladder cancer with very high tumour mutational burden
Nature, Published online: 08 April 2024; doi:10.1038/s41586-024-07379-z
Tumor-selective activity of RAS-GTP inhibition in pancreatic cancer
Nature, Published online: 20 March 2024; doi:10.1038/s41586-024-07224-3
A synthetic proteome-scale strategy enables the identification of a diverse range of human proteins that can induce the degradation or stabilization of a target protein in a proximity-dependent way.
Nature, Published online: 13 March 2024; doi:10.1038/s41586-024-07177-7
We uncover key processes of the genomic evolution of small cell lung cancer under therapy, identify the common ancestor as the source of clonal diversity at relapse and show central genomic patterns associated with drug response.
Nature, Published online: 15 January 2024; doi:10.1038/s41586-024-07050-7
Author Correction: A genomic mutational constraint map using variation in 76,156 human genomes
Nature, Published online: 08 December 2023; doi:10.1038/d41586-023-03394-8
Researchers who are as skilled in the studio as they are in the lab are forced to choose between disciplines.
Oncogene, Published online: 29 November 2023; doi:10.1038/s41388-023-02903-3
The RORɣ/SREBP2 pathway is a master regulator of cholesterol metabolism and serves as potential therapeutic target in t(4;11) leukemia
Nature Biotechnology, Published online: 18 October 2023; doi:10.1038/s41587-023-02025-x
Author Correction: Enhancing untargeted metabolomics using metadata-based source annotation
Nature Biotechnology, Published online: 04 September 2023; doi:10.1038/s41587-023-01937-y
Metabolites and RNA in a tissue section are profiled simultaneously.
Nature, Published online: 10 May 2023; doi:10.1038/s41586-023-05896-x
An initial draft of the human pangenome is presented and made publicly available by the Human Pangenome Reference Consortium; the draft contains 94 de novo haplotype assemblies from 47 ancestrally diverse individuals.
Nature, Published online: 30 November 2022; doi:10.1038/s41586-022-05448-9
Exome sequence data from 628,388 individuals was used to identify 24 risk loci in 40,208 carriers of clonal haematopoiesis of indeterminate potential and link them to other conditions including COVID-19, cardiovascular disease and cancer.
Cell Death Discovery, Published online: 02 September 2022; doi:10.1038/s41420-022-01165-4
Pharmacological inhibition and reversal of pancreatic acinar ductal metaplasia
Nature, Published online: 17 August 2022; doi:10.1038/s41586-022-05046-9
Live-seq, a single-cell transcriptome profiling approach that preserves cell viability during RNA extraction using fluidic force microscopy, can address a range of biological questions by transforming scRNA-seq from an end-point to a temporal analysis approach.
Nature, Published online: 10 August 2022; doi:10.1038/s41586-022-05066-5
Truncation of exon 18 of FGFR2 (FGFR2ΔE18) is a potent driver mutation in mice and humans, and FGFR-targeted therapy should be considered for patients with cancer expressing stable FGFR2ΔE18 variants.
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