arXiv:2512.00142v1 Announce Type: cross Abstract: This research introduces the Decentralized Finance (DeFi) TrustBoost Framework, which combines blockchain technology and Explainable AI to address challenges faced by lenders underwriting small business loan applications from low-wealth households. The framework is designed with a strong emphasis on fulfilling four crucial requirements of blockchain and AI systems: confidentiality, compliance with data protection laws, resistance to adversarial attacks, and compliance with regulatory audits. It presents a technique for tamper-proof auditing of automated AI decisions and a strategy for on-chain (inside-blockchain) and off-chain data storage to facilitate collaboration within and across financial organizations.

arXiv:2512.00271v1 Announce Type: cross Abstract: Purpose: To benchmark open-source or commercial medical image-specific VLMs against real-world radiologist-written reports. Methods: This retrospective study included adult patients who presented to the emergency department between January 2022 and April 2025 and underwent same-day CXR and CT for febrile or respiratory symptoms. Reports from five VLMs (AIRead, Lingshu, MAIRA-2, MedGemma, and MedVersa) and radiologist-written reports were randomly presented and blindly evaluated by three thoracic radiologists using four criteria: RADPEER, clinical acceptability, hallucination, and language clarity. Comparative performance was assessed using generalized linear mixed models, with radiologist-written reports treated as the reference. Finding-level analyses were also performed with CT as the reference. Results: A total of 478 patients (median age, 67 years [interquartile range, 50-78]; 282 men [59.0%]) were included. AIRead demonstrated the lowest RADPEER 3b rate (5.3% [76/1434] vs. radiologists 13.9% [200/1434]; P<.001 whereas other vlms showed higher disagreement rates p clinical acceptability was the highest with airead vs. radiologists while performed worse hallucinations were rare comparable to but frequent models language clarity lingshu and medversa compared sensitivity varied substantially across for common findings: maira-2 medgemma conclusion: medical cxr report generation exhibited variable performance in quality diagnostic measures.>

arXiv:2512.00281v1 Announce Type: cross Abstract: Early detection of malignant lung nodules is critical, but its dependence on size and growth in screening inherently delays diagnosis. We present an AI system that redefines lung cancer screening by performing both detection and malignancy diagnosis directly at the nodule level on low-dose CT scans. To address limitations in dataset scale and explainability, we designed an ensemble of shallow deep learning and feature-based specialized models. Trained and evaluated on 25,709 scans with 69,449 annotated nodules, the system outperforms radiologists, Lung-RADS, and leading AI models (Sybil, Brock, Google, Kaggle). It achieves an area under the receiver operating characteristic curve (AUC) of 0.98 internally and 0.945 on an independent cohort. With 0.5 false positives per scan at 99.3\% sensitivity, it addresses key barriers to AI adoption. Critically, it outperforms radiologists across all nodule sizes and stages, excelling in stage 1 cancers, and all growth-based metrics, including the least accurate: Volume-Doubling Time. It also surpasses radiologists by up to one year in diagnosing indeterminate and slow-growing nodules.

arXiv:2512.00350v1 Announce Type: cross Abstract: We introduce MedCondDiff, a diffusion-based framework for multi-organ medical image segmentation that is efficient and anatomically grounded. The model conditions the denoising process on semantic priors extracted by a Pyramid Vision Transformer (PVT) backbone, yielding a semantically guided and lightweight diffusion architecture. This design improves robustness while reducing both inference time and VRAM usage compared to conventional diffusion models. Experiments on multi-organ, multi-modality datasets demonstrate that MedCondDiff delivers competitive performance across anatomical regions and imaging modalities, underscoring the potential of semantically guided diffusion models as an effective class of architectures for medical imaging tasks.

arXiv:2512.00403v1 Announce Type: cross Abstract: Recent work on autonomous scientific discovery has leveraged LLM-based agents to integrate problem specification, experiment planning, and execution into end-to-end systems. However, these frameworks are often confined to narrow application domains, offer limited real-time interaction with researchers, and lack principled mechanisms for determining when to halt exploration, resulting in inefficiencies, reproducibility challenges, and under-utilized human expertise. To address these gaps, we propose \textit{SelfAI}, a general multi-agent platform that combines a User Agent for translating high-level research objectives into standardized experimental configurations, a Cognitive Agent powered by LLMs with optimal stopping criteria to iteratively refine hyperparameter searches, and an Experiment Manager responsible for orchestrating parallel, fault-tolerant training workflows across heterogeneous hardware while maintaining a structured knowledge base for continuous feedback. We further introduce two novel evaluation metrics, Score and $\text{AUP}_D$, to quantify discovery efficiency and search diversity. Across regression, NLP, computer vision, scientific computing, medical imaging, and drug discovery benchmarks, SelfAI consistently achieves strong performance and reduces redundant trials compared to classical Bayesian optimization and LLM-based baselines, while enabling seamless interaction with human researchers.

arXiv:2512.00496v1 Announce Type: cross Abstract: As deep learning models evolve, new applications and challenges are rapidly emerging. Tasks that once relied on a single modality, such as text, images, or audio, are now enriched by seamless interactions between multimodal data. These connections bridge information gaps: an image can visually materialize a text, while audio can add context to an image. Researchers have developed numerous multimodal models, but most rely on resource-intensive training across multiple modalities. Similarly, extending these models to new languages often follows the same resource-heavy training strategy. In this work, we propose a multimodal and multilingual architecture, CACARA, trained through emergent alignment learning, enabling the seamless integration of new modalities into an existing bimodal/multimodal model without requiring full retraining. This work breaks new ground by demonstrating that this emergent alignment paradigm can unlock multilingual capabilities from monolingual training. By fine-tuning the newly incorporated modality only on data aligned with the English language, our model develops support for over 100 languages without explicit multilingual pretraining or tuning of the text encoder. Such emergent multimodal and multilingual properties are gained efficiently, preserving previously learned knowledge at a training cost comparable to that of a monolingual model. Our strategy achieves up to a 14.24 percentage points improvement in R@1 audio-to-text retrieval, outperforming state-of-the-art multimodal models -- all without the heavy computational cost of retraining across every modality and language.

arXiv:2512.00563v1 Announce Type: cross Abstract: Respiratory diseases remain major global health challenges, and traditional auscultation is often limited by subjectivity, environmental noise, and inter-clinician variability. This study presents an explainable multimodal deep learning framework for automatic lung-disease detection using respiratory audio signals. The proposed system integrates two complementary representations: a spectral-temporal encoder based on a CNN-BiLSTM Attention architecture, and a handcrafted acoustic-feature encoder capturing physiologically meaningful descriptors such as MFCCs, spectral centroid, spectral bandwidth, and zero-crossing rate. These branches are combined through late-stage fusion to leverage both data-driven learning and domain-informed acoustic cues. The model is trained and evaluated on the Asthma Detection Dataset Version 2 using rigorous preprocessing, including resampling, normalization, noise filtering, data augmentation, and patient-level stratified partitioning. The study achieved strong generalization with 91.21% accuracy, 0.899 macro F1-score, and 0.9866 macro ROC-AUC, outperforming all ablated variants. An ablation study confirms the importance of temporal modeling, attention mechanisms, and multimodal fusion. The framework incorporates Grad-CAM, Integrated Gradients, and SHAP, generating interpretable spectral, temporal, and feature-level explanations aligned with known acoustic biomarkers to build clinical transparency. The findings demonstrate the framework's potential for telemedicine, point-of-care diagnostics, and real-world respiratory screening.

arXiv:2512.00579v1 Announce Type: cross Abstract: When solving tasks in the field of natural language processing, we sometimes need dictionary tools, such as lexicons, word form dictionaries or knowledge bases. However, the availability of dictionary data is insufficient in many languages, especially in the case of low resourced languages. In this article, we introduce a new conceptual dictionary for the Slovak language as the first linguistic tool of this kind. Since Slovak language is a language with limited linguistic resources and there are currently not available any machine-readable linguistic data sources with a sufficiently large volume of data, many tasks which require automated processing of Slovak text achieve weaker results compared to other languages and are almost impossible to solve.

arXiv:2512.00590v1 Announce Type: cross Abstract: Knowledge graphs (KGs) provide structured, verifiable grounding for large language models (LLMs), but current LLM-based systems commonly use KGs as auxiliary structures for text retrieval, leaving their intrinsic quality underexplored. In this work, we propose Wikontic, a multi-stage pipeline that constructs KGs from open-domain text by extracting candidate triplets with qualifiers, enforcing Wikidata-based type and relation constraints, and normalizing entities to reduce duplication. The resulting KGs are compact, ontology-consistent, and well-connected; on MuSiQue, the correct answer entity appears in 96% of generated triplets. On HotpotQA, our triplets-only setup achieves 76.0 F1, and on MuSiQue 59.8 F1, matching or surpassing several retrieval-augmented generation baselines that still require textual context. In addition, Wikontic attains state-of-the-art information-retention performance on the MINE-1 benchmark (86%), outperforming prior KG construction methods. Wikontic is also efficient at build time: KG construction uses less than 1,000 output tokens, about 3$\times$ fewer than AriGraph and $

arXiv:2512.00714v1 Announce Type: cross Abstract: Early cancer detection remains one of the most critical challenges in modern healthcare, where delayed diagnosis significantly reduces survival outcomes. Recent advancements in artificial intelligence, particularly deep learning, have enabled transformative progress in medical imaging analysis. Deep learning-based computer vision models, such as convolutional neural networks (CNNs), transformers, and hybrid attention architectures, can automatically extract complex spatial, morphological, and temporal patterns from multimodal imaging data including MRI, CT, PET, mammography, histopathology, and ultrasound. These models surpass traditional radiological assessment by identifying subtle tissue abnormalities and tumor microenvironment variations invisible to the human eye. At a broader scale, the integration of multimodal imaging with radiogenomics linking quantitative imaging features with genomics, transcriptomics, and epigenetic biomarkers has introduced a new paradigm for personalized oncology. This radiogenomic fusion allows the prediction of tumor genotype, immune response, molecular subtypes, and treatment resistance without invasive biopsies.

arXiv:2512.00949v1 Announce Type: cross Abstract: For patients undergoing systemic cancer therapy, the time between clinic visits is full of uncertainties and risks of unmonitored side effects. To bridge this gap in care, we developed and prospectively trialed a multi-modal AI framework for remote patient monitoring (RPM). This system integrates multi-modal data from the HALO-X platform, such as demographics, wearable sensors, daily surveys, and clinical events. Our observational trial is one of the largest of its kind and has collected over 2.1 million data points (6,080 patient-days) of monitoring from 84 patients. We developed and adapted a multi-modal AI model to handle the asynchronous and incomplete nature of real-world RPM data, forecasting a continuous risk of future adverse events. The model achieved an accuracy of 83.9% (AUROC=0.70). Notably, the model identified previous treatments, wellness check-ins, and daily maximum heart rate as key predictive features. A case study demonstrated the model's ability to provide early warnings by outputting escalating risk profiles prior to the event. This work establishes the feasibility of multi-modal AI RPM for cancer care and offers a path toward more proactive patient support.(Accepted at Europe NeurIPS 2025 Multimodal Representation Learning for Healthcare Workshop)

arXiv:2512.01167v1 Announce Type: cross Abstract: This study presents a reinforcement learning (RL)-based control strategy for adaptive lighting regulation in controlled environments using a low-power microcontroller. A model-free Q-learning algorithm was implemented to dynamically adjust the brightness of a Light-Emitting Diode (LED) based on real-time feedback from a light-dependent resistor (LDR) sensor. The system was trained to stabilize at 13 distinct light intensity levels (L1 to L13), with each target corresponding to a specific range within the 64-state space derived from LDR readings. A total of 130 trials were conducted, covering all target levels with 10 episodes each. Performance was evaluated in terms of convergence speed, steps taken, and time required to reach target states. Box plots and histograms were generated to analyze the distribution of training time and learning efficiency across targets. Experimental validation demonstrated that the agent could effectively learn to stabilize at varying light levels with minimal overshooting and smooth convergence, even in the presence of environmental perturbations. This work highlights the feasibility of lightweight, on-device RL for energy-efficient lighting control and sets the groundwork for multi-modal environmental control applications in resource-constrained agricultural systems.

arXiv:2502.07663v3 Announce Type: replace Abstract: AI systems are increasingly intertwined with daily life, assisting users with various tasks and guiding decision-making. This integration introduces risks of AI-driven manipulation, where such systems may exploit users' cognitive biases and emotional vulnerabilities to steer them toward harmful outcomes. Through a randomized between-subjects experiment with 233 participants, we examined human susceptibility to such manipulation in financial (e.g., purchases) and emotional (e.g., conflict resolution) decision-making contexts. Participants interacted with one of three AI agents: a neutral agent (NA) optimizing for user benefit without explicit influence, a manipulative agent (MA) designed to covertly influence beliefs and behaviors, or a strategy-enhanced manipulative agent (SEMA) equipped with established psychological tactics, allowing it to select and apply them adaptively during interactions to reach its hidden objectives. By analyzing participants' preference ratings, we found significant susceptibility to AI-driven manipulation. Particularly across both decision-making domains, interacting with the manipulative agents significantly increased the odds of rating hidden incentives higher than optimal options (Financial, MA: OR=5.24, SEMA: OR=7.96; Emotional, MA: OR=5.52, SEMA: OR=5.71) compared to the NA group. Notably, we found no clear evidence that employing psychological strategies (SEMA) was overall more effective than simple manipulative objectives (MA) on our primary outcomes. Hence, AI-driven manipulation could become widespread even without requiring sophisticated tactics and expertise. While our findings are preliminary and derived from hypothetical, low-stakes scenarios, we highlight a critical vulnerability in human-AI interactions, emphasizing the need for ethical safeguards and regulatory frameworks to protect human autonomy.

arXiv:2510.22814v3 Announce Type: replace Abstract: This article analyzes the existential risks artificial intelligence (AI) poses to humanity, tracing the trajectory from current AI to ultraintelligence. Drawing on Irving J. Good and Nick Bostrom's theoretical work, plus recent publications (AI 2027; If Anyone Builds It, Everyone Dies), it explores AGI and superintelligence. Considering machines' exponentially growing cognitive power and hypothetical IQs, it addresses the ethical and existential implications of an intelligence vastly exceeding humanity's, fundamentally alien. Human extinction may result not from malice, but from uncontrollable, indifferent cognitive superiority.

arXiv:2502.07299v3 Announce Type: replace-cross Abstract: The interactions between DNA, RNA, and proteins are fundamental to biological processes, as illustrated by the central dogma of molecular biology. Although modern biological pre-trained models have achieved great success in analyzing these macromolecules individually, their interconnected nature remains underexplored. This paper follows the guidance of the central dogma to redesign both the data and model pipeline and offers a comprehensive framework, Life-Code, that spans different biological functions. As for data flow, we propose a unified pipeline to integrate multi-omics data by reverse-transcribing RNA and reverse-translating amino acids into nucleotide-based sequences. As for the model, we design a codon tokenizer and a hybrid long-sequence architecture to encode the interactions between coding and non-coding regions through masked modeling pre-training. To model the translation and folding process with coding sequences, Life-Code learns protein structures of the corresponding amino acids by knowledge distillation from off-the-shelf protein language models. Such designs enable Life-Code to capture complex interactions within genetic sequences, providing a more comprehensive understanding of multi-omics with the central dogma. Extensive experiments show that Life-Code achieves state-of-the-art results on various tasks across three omics, highlighting its potential for advancing multi-omics analysis and interpretation.

arXiv:2505.18190v4 Announce Type: replace-cross Abstract: Physics sensing plays a central role in many scientific and engineering domains, which inherently involves two coupled tasks: reconstructing dense physical fields from sparse observations and optimizing scattered sensor placements to observe maximum information. While deep learning has made rapid advances in sparse-data reconstruction, existing methods generally omit optimization of sensor placements, leaving the mutual enhancement between reconstruction and placement on the shelf. To change this suboptimal practice, we propose PhySense, a synergistic two-stage framework that learns to jointly reconstruct physical fields and to optimize sensor placements, both aiming for accurate physics sensing. The first stage involves a flow-based generative model enhanced by cross-attention to adaptively fuse sparse observations. Leveraging the reconstruction feedback, the second stage performs sensor placement via projected gradient descent to satisfy spatial constraints. We further prove that the learning objectives of the two stages are consistent with classical variance-minimization principles, providing theoretical guarantees. Extensive experiments across three challenging benchmarks, especially a 3D geometry dataset, indicate PhySense achieves state-of-the-art physics sensing accuracy and discovers informative sensor placements previously unconsidered. Code is available at this repository: https://github.com/thuml/PhySense.

arXiv:2509.24365v2 Announce Type: replace-cross Abstract: Unified Multimodal Models (UMMs) built on shared autoregressive (AR) transformers are attractive for their architectural simplicity. However, we identify a critical limitation: when trained on multimodal inputs, modality-shared transformers suffer from severe gradient conflicts between vision and text, particularly in shallow and deep layers. We trace this issue to the fundamentally different low-level statistical properties of images and text, while noting that conflicts diminish in middle layers where representations become more abstract and semantically aligned. To overcome this challenge, we propose Uni-X, a two-end-separated, middle-shared architecture. Uni-X dedicates its initial and final layers to modality-specific processing, while maintaining shared parameters in the middle layers for high-level semantic fusion. This X-shaped design not only eliminates gradient conflicts at both ends but also further alleviates residual conflicts in the shared layers. Extensive experiments validate the effectiveness of Uni-X. Under identical training conditions, Uni-X achieves superior training efficiency compared to strong baselines. When scaled to 3B parameters with larger training data, Uni-X matches or surpasses 7B AR-based UMMs, achieving a GenEval score of 82 for image generation alongside strong performance in text and vision understanding tasks. These results establish Uni-X as a parameter-efficient and scalable foundation for future unified multimodal modeling. Our code is available at https://github.com/CURRENTF/Uni-X

arXiv:2509.25721v3 Announce Type: replace-cross Abstract: We present an extended version of the AI Productivity Index (APEX-v1-extended), a benchmark for assessing whether frontier models are capable of performing economically valuable tasks in four jobs: investment banking associate, management consultant, big law associate, and primary care physician (MD). This technical report details the extensions to APEX-v1, including an increase in the held-out evaluation set from n = 50 to n = 100 cases per job (n = 400 total) and updates to the grading methodology. We present a new leaderboard, where GPT5 (Thinking = High) remains the top performing model with a score of 67.0%. APEX-v1-extended shows that frontier models still have substantial limitations when performing typical professional tasks. To support further research, we are open sourcing n = 25 non-benchmark example cases per role (n = 100 total) along with our evaluation harness.

arXiv:2511.12796v2 Announce Type: replace-cross Abstract: Reinforcement Learning from Human Feedback (RLHF) relies on preference modeling to align machine learning systems with human values, yet the popular approach of random pair sampling with Bradley-Terry modeling is statistically limited and inefficient under constrained annotation budgets. In this work, we explore alternative sampling and evaluation strategies for preference inference in RLHF, drawing inspiration from areas such as game theory, statistics, and social choice theory. Our best-performing method, Swiss InfoGain, employs a Swiss tournament system with a proxy mutual-information-gain pairing rule, which significantly outperforms all other methods in constrained annotation budgets while also being more sample-efficient. Even in high-resource settings, we can identify superior alternatives to the Bradley-Terry baseline. Our experiments demonstrate that adaptive, resource-aware strategies reduce redundancy, enhance robustness, and yield statistically significant improvements in preference learning, highlighting the importance of balancing alignment quality with human workload in RLHF pipelines.