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S100A6 promotes liver metastasis by activating FGFR3 signaling in <i>BAP1</i>-deficient uveal melanoma

Oncogene, Published online: 04 April 2026; doi:10.1038/s41388-026-03766-0

S100A6 promotes liver metastasis by activating FGFR3 signaling in BAP1-deficient uveal melanoma

14,15-epoxyeicosatrienoic acid drives intestinal adenoma growth and its value as an early biomarker for intestinal adenoma occurrence

Oncogenesis, Published online: 11 March 2026; doi:10.1038/s41389-026-00604-6

14,15-epoxyeicosatrienoic acid drives intestinal adenoma growth and its value as an early biomarker for intestinal adenoma occurrence

Operational Robustness of LLMs on Code Generation

arXiv:2602.18800v1 Announce Type: cross Abstract: It is now common practice in software development for large language models (LLMs) to be used to generate program code. It is desirable to evaluate the robustness of LLMs for this usage. This paper is concerned in particular with how sensitive LLMs are to variations in descriptions of the coding tasks. However, existing techniques for evaluating this robustness are unsuitable for code generation because the input data space of natural language descriptions is discrete. To address this problem, we propose a robustness evaluation method called scenario domain analysis, which aims to find the expected minimal change in the natural language descriptions of coding tasks that would cause the LLMs to produce incorrect outputs. We have formally proved the theoretical properties of the method and also conducted extensive experiments to evaluate the robustness of four state-of-the-art art LLMs: Gemini-pro, Codex, Llamma2 and Falcon 7B, and have found that we are able to rank these with confidence from best to worst. Moreover, we have also studied how robustness varies in different scenarios, including the variations with the topic of the coding task and with the complexity of its sample solution, and found that robustness is lower for more complex tasks and also lower for more advanced topics, such as multi-threading and data structures.

Fore-Mamba3D: Mamba-based Foreground-Enhanced Encoding for 3D Object Detection

arXiv:2602.19536v1 Announce Type: cross Abstract: Linear modeling methods like Mamba have been merged as the effective backbone for the 3D object detection task. However, previous Mamba-based methods utilize the bidirectional encoding for the whole non-empty voxel sequence, which contains abundant useless background information in the scenes. Though directly encoding foreground voxels appears to be a plausible solution, it tends to degrade detection performance. We attribute this to the response attenuation and restricted context representation in the linear modeling for fore-only sequences. To address this problem, we propose a novel backbone, termed Fore-Mamba3D, to focus on the foreground enhancement by modifying Mamba-based encoder. The foreground voxels are first sampled according to the predicted scores. Considering the response attenuation existing in the interaction of foreground voxels across different instances, we design a regional-to-global slide window (RGSW) to propagate the information from regional split to the entire sequence. Furthermore, a semantic-assisted and state spatial fusion module (SASFMamba) is proposed to enrich contextual representation by enhancing semantic and geometric awareness within the Mamba model. Our method emphasizes foreground-only encoding and alleviates the distance-based and causal dependencies in the linear autoregression model. The superior performance across various benchmarks demonstrates the effectiveness of Fore-Mamba3D in the 3D object detection task.
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