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Integrative Multi-Omics Mendelian Randomization Analysis Identifies NIT2 as a Potential Metabolic Risk Gene in Hepatocellular Carcinoma

2 September 2026 at 18:00

J Gene Med. 2026 Sep;28(9):e70111. doi: 10.1002/jgm.70111.

ABSTRACT

BACKGROUND: Metabolic pathways are crucial in hepatocellular carcinoma (HCC) pathogenesis, but causal metabolic genes remain unclear. This study used Summary data-based Mendelian Randomization (SMR) and colocalization to identify metabolism-related genetic loci influencing HCC risk.

METHODS: Differentially expressed genes in hepatic malignancy phenotype versus normal tissues from TCGA and GTEx were analyzed. Metabolism-related candidates were examined via SMR and colocalization using multi-omics data: methylation (mQTL), expression (eQTL), and protein (pQTL) quantitative trait loci.

RESULTS: Multi-omics integration identified NIT2 as a key metabolic regulator for HCC. The cg13016775 locus of NIT2 was associated with elevated HCC risk at gene (OR = 1.618, 95% CI: 1.199-2.182) and protein (OR = 4.432, 95% CI: 1.783-11.018) levels. Colocalization supported a shared causal variant (PPH4 > 0.6), linking NIT2 to hepatocarcinogenesis via metabolic regulation.

CONCLUSIONS: This study provides multi-omics evidence for NIT2 as a potential causal gene in HCC, enhancing understanding of metabolic contributions to HCC pathogenesis and highlighting integrative genomics for uncovering causal relationships.

PMID:42681890 | PMC:PMC13534973 | DOI:10.1002/jgm.70111

TRACE: A Multi-Agent System for Autonomous Physical Reasoning in Seismological

arXiv:2603.21152v2 Announce Type: replace-cross Abstract: Inferring the physical mechanisms that govern earthquake sequences from indirect geophysical observations remains difficult, particularly across tectonically distinct environments where similar seismic patterns can reflect different underlying processes. Current interpretations rely heavily on the expert synthesis of catalogs, spatiotemporal statistics, and candidate physical models, limiting reproducibility and the systematic transfer of insight across settings. Here we present TRACE (Trans-perspective Reasoning and Automated Comprehensive Evaluator), a multi-agent system that combines large language model planning with formal seismological constraints to derive auditable, physically grounded mechanistic inference from raw observations. Applied to the 2019 Ridgecrest sequence, TRACE autonomously identifies stress-perturbation-induced delayed triggering, resolving the cascading interaction between the Mw 6.4 and Mw 7.1 mainshocks; in the Santorini-Kolumbo case, the system identifies a structurally guided intrusion model, distinguishing fault-channeled episodic migration from the continuous propagation expected in homogeneous crustal failure. By providing a generalizable logical infrastructure for interpreting heterogeneous seismic phenomena, TRACE advances the field from expert-dependent analysis toward knowledge-guided autonomous discovery in Earth sciences.

Multi-Modal Sensing and Fusion in mmWave Beamforming for Connected Vehicles: A Transformer Based Framework

arXiv:2602.13606v1 Announce Type: cross Abstract: Millimeter wave (mmWave) communication, utilizing beamforming techniques to address the inherent path loss limitation, is considered as one of the key technologies to support ever increasing high throughput and low latency demands of connected vehicles. However, adopting standard defined beamforming approach in highly dynamic vehicular environments often incurs high beam training overheads and reduction in the available airtime for communications, which is mainly due to exchanging pilot signals and exhaustive beam measurements. To this end, we present a multi-modal sensing and fusion learning framework as a potential alternative solution to reduce such overheads. In this framework, we first extract the representative features from the sensing modalities by modality specific encoders, then, utilize multi-head cross-modal attention to learn dependencies and correlations between different modalities, and subsequently fuse the multimodal features to obtain predicted top-k beams so that the best line-of-sight links can be proactively established. To show the generalizability of the proposed framework, we perform a comprehensive experiment in four different vehicle-to-infrastructure (V2I) and vehicle-to-vehicle (V2V) scenarios from real world multimodal and 60 GHz mmWave wireless sensing data. The experiment reveals that the proposed framework (i) achieves up to 96.72% accuracy on predicting top-15 beams correctly, (ii) incurs roughly 0.77 dB average power loss, and (iii) improves the overall latency and beam searching space overheads by 86.81% and 76.56% respectively for top-15 beams compared to standard defined approach.
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