Normal view
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cs.AI, q-bio.NC updates on arXiv.org
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Which Tokens Should SFT Actually Learn? A Token-Trimming Perspective on Mathematical Reasoning
arXiv:2609.09707v1 Announce Type: new Abstract: Supervised fine-tuning (SFT) applies a uniform cross-entropy loss to all target tokens, even though different tokens provide unequal learning signals for mathematical reasoning. This uniform treatment can over-sharpen already mastered tokens while amplifying learning pressure on uncertain, low-confidence tokens, leading to suboptimal training dynamics. We propose Trimmed Logit-Gap SFT (TrimSFT), a simple token-level reweighting method that scales
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Omics In Lung
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Early stage nonsmall cell lung cancer: Toward a risk-adaptive paradigm in the era of biologic precision
CA Cancer J Clin. 2026 Sep-Oct;76(5):e70100. doi: 10.3322/caac.70100.ABSTRACTThe clinical landscape of early stage nonsmall cell lung cancer is at transformative crossroads. Driven by the widespread adoption of low-dose computed tomography screening, the frequent detection of ground-glass opacities, and a rising incidence among never-smokers, the diagnostic center of gravity has shifted toward earlier, potentially curable disease. This shift has been accompanied by equally important therapeutic
Early stage nonsmall cell lung cancer: Toward a risk-adaptive paradigm in the era of biologic precision
CA Cancer J Clin. 2026 Sep-Oct;76(5):e70100. doi: 10.3322/caac.70100.
ABSTRACT
The clinical landscape of early stage nonsmall cell lung cancer is at transformative crossroads. Driven by the widespread adoption of low-dose computed tomography screening, the frequent detection of ground-glass opacities, and a rising incidence among never-smokers, the diagnostic center of gravity has shifted toward earlier, potentially curable disease. This shift has been accompanied by equally important therapeutic advances, including parenchyma-sparing surgical techniques, minimally invasive platforms enhanced by digital navigation, and the transformative integration of perioperative immunotherapy and targeted agents. Concurrently, noninvasive monitoring approaches, such as liquid biopsy, have emerged as powerful tools to guide precision management. Despite this progress, substantial barriers to achieving a universal cure persist. Clinicians continue to face uncertainty in the management of ground-glass opacities, the anatomy-based TNM staging system fails to capture the biologic heterogeneity of early tumors, and global disparities in access to innovation remain unresolved. To address these challenges, the authors propose a shift toward a risk-adaptive management paradigm that harnesses artificial intelligence-driven analytics and multi-omics profiling to tailor treatment intensity according to each patient's biologic risk. Such an approach would enable appropriate escalation for high-risk individuals while permitting safe de-escalation for those at low risk. This holistic, lifespan-oriented strategy must be embraced to deliver equitable and durable cures for patients with early stage nonsmall cell lung cancer.
PMID:42713910 | PMC:PMC13555834 | DOI:10.3322/caac.70100
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(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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Early stage nonsmall cell lung cancer: Toward a risk-adaptive paradigm in the era of biologic precision
CA Cancer J Clin. 2026 Sep-Oct;76(5):e70100. doi: 10.3322/caac.70100.ABSTRACTThe clinical landscape of early stage nonsmall cell lung cancer is at transformative crossroads. Driven by the widespread adoption of low-dose computed tomography screening, the frequent detection of ground-glass opacities, and a rising incidence among never-smokers, the diagnostic center of gravity has shifted toward earlier, potentially curable disease. This shift has been accompanied by equally important therapeutic
Early stage nonsmall cell lung cancer: Toward a risk-adaptive paradigm in the era of biologic precision
CA Cancer J Clin. 2026 Sep-Oct;76(5):e70100. doi: 10.3322/caac.70100.
ABSTRACT
The clinical landscape of early stage nonsmall cell lung cancer is at transformative crossroads. Driven by the widespread adoption of low-dose computed tomography screening, the frequent detection of ground-glass opacities, and a rising incidence among never-smokers, the diagnostic center of gravity has shifted toward earlier, potentially curable disease. This shift has been accompanied by equally important therapeutic advances, including parenchyma-sparing surgical techniques, minimally invasive platforms enhanced by digital navigation, and the transformative integration of perioperative immunotherapy and targeted agents. Concurrently, noninvasive monitoring approaches, such as liquid biopsy, have emerged as powerful tools to guide precision management. Despite this progress, substantial barriers to achieving a universal cure persist. Clinicians continue to face uncertainty in the management of ground-glass opacities, the anatomy-based TNM staging system fails to capture the biologic heterogeneity of early tumors, and global disparities in access to innovation remain unresolved. To address these challenges, the authors propose a shift toward a risk-adaptive management paradigm that harnesses artificial intelligence-driven analytics and multi-omics profiling to tailor treatment intensity according to each patient's biologic risk. Such an approach would enable appropriate escalation for high-risk individuals while permitting safe de-escalation for those at low risk. This holistic, lifespan-oriented strategy must be embraced to deliver equitable and durable cures for patients with early stage nonsmall cell lung cancer.
PMID:42713910 | DOI:10.3322/caac.70100
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cs.AI, q-bio.NC updates on arXiv.org
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Human-AI Collaboration in Science at Scale: A Global Large-scale Randomized Field Experiment
arXiv:2605.24180v1 Announce Type: cross Abstract: Collaboration is the defining mode of modern science, yet its core mechanism -- feedback -- remains hard to observe, difficult to scale, and unequally distributed. Here we test whether large language models (LLMs) can contribute to this hidden but vital practice and reallocate scientific feedback, an essential yet scarce resource for knowledge production. In a global large-scale randomized field experiment, we delivered customized LLM-generated
Human-AI Collaboration in Science at Scale: A Global Large-scale Randomized Field Experiment
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Cell
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STING signaling modulation by COPII cargo recognition
Lyu et al. identify the STING-ER-exit motif and the mechanism of its recognition by the COPII vesicle cargo-binding protein SEC24C. This study reveals how STING achieves controlled rather than constitutive ER exit and how COPII cargo recognition of STING can be modulated to control STING signaling.
STING signaling modulation by COPII cargo recognition
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Oncogene - Issue - nature.com science feeds
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METTL16 enhances proteasome inhibitor resistance in multiple myeloma by inhibiting eIF2α-PERK interaction and promoting PSMB5 translation
Oncogene, Published online: 13 March 2026; doi:10.1038/s41388-026-03706-yMETTL16 enhances proteasome inhibitor resistance in multiple myeloma by inhibiting eIF2α-PERK interaction and promoting PSMB5 translation
METTL16 enhances proteasome inhibitor resistance in multiple myeloma by inhibiting eIF2α-PERK interaction and promoting PSMB5 translation
Oncogene, Published online: 13 March 2026; doi:10.1038/s41388-026-03706-y
METTL16 enhances proteasome inhibitor resistance in multiple myeloma by inhibiting eIF2α-PERK interaction and promoting PSMB5 translation-
cs.AI, q-bio.NC updates on arXiv.org
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OSExpert: Computer-Use Agents Learning Professional Skills via Exploration
arXiv:2603.07978v1 Announce Type: new Abstract: General-purpose computer-use agents have shown impressive performance across diverse digital environments. However, our new benchmark, OSExpert-Eval, indicates they remain far less helpful than human experts. Although inference-time scaling enables adaptation, these agents complete complex tasks inefficiently with degraded performance, transfer poorly to unseen UIs, and struggle with fine-grained action sequences. To solve the problem, we introduc
OSExpert: Computer-Use Agents Learning Professional Skills via Exploration
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cs.AI, q-bio.NC updates on arXiv.org
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Long-Short Term Agents for Pure-Vision Bronchoscopy Robotic Autonomy
arXiv:2603.07909v1 Announce Type: cross Abstract: Accurate intraoperative navigation is essential for robot-assisted endoluminal intervention, but remains difficult because of limited endoscopic field of view and dynamic artifacts. Existing navigation platforms often rely on external localization technologies, such as electromagnetic tracking or shape sensing, which increase hardware complexity and remain vulnerable to intraoperative anatomical mismatch. We present a vision-only autonomy framew
Long-Short Term Agents for Pure-Vision Bronchoscopy Robotic Autonomy
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cs.AI, q-bio.NC updates on arXiv.org
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EndoSERV: A Vision-based Endoluminal Robot Navigation System
arXiv:2603.08324v1 Announce Type: cross Abstract: Robot-assisted endoluminal procedures are increasingly used for early cancer intervention. However, the intricate, narrow and tortuous pathways within the luminal anatomy pose substantial difficulties for robot navigation. Vision-based navigation offers a promising solution, but existing localization approaches are error-prone due to tissue deformation, in vivo artifacts and a lack of distinctive landmarks for consistent localization. This paper
EndoSERV: A Vision-based Endoluminal Robot Navigation System
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cs.AI, q-bio.NC updates on arXiv.org
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Towards Effective Orchestration of AI x DB Workloads
arXiv:2603.03772v1 Announce Type: cross Abstract: AI-driven analytics are increasingly crucial to data-centric decision-making. The practice of exporting data to machine learning runtimes incurs high overhead, limits robustness to data drift, and expands the attack surface, especially in multi-tenant, heterogeneous data systems. Integrating AI directly into database engines, while offering clear benefits, introduces challenges in managing joint query processing and model execution, optimizing e
Towards Effective Orchestration of AI x DB Workloads
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cs.AI, q-bio.NC updates on arXiv.org
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GeoSeg: Training-Free Reasoning-Driven Segmentation in Remote Sensing Imagery
arXiv:2603.03983v1 Announce Type: cross Abstract: Recent advances in MLLMs are reframing segmentation from fixed-category prediction to instruction-grounded localization. While reasoning based segmentation has progressed rapidly in natural scenes, remote sensing lacks a generalizable solution due to the prohibitive cost of reasoning-oriented data and domain-specific challenges like overhead viewpoints. We present GeoSeg, a zero-shot, training-free framework that bypasses the supervision bottlen
GeoSeg: Training-Free Reasoning-Driven Segmentation in Remote Sensing Imagery
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cs.AI, q-bio.NC updates on arXiv.org
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Monitoring AI-Modified Content at Scale: A Case Study on the Impact of ChatGPT on AI Conference Peer Reviews
arXiv:2403.07183v3 Announce Type: replace-cross Abstract: We present an approach for estimating the fraction of text in a large corpus which is likely to be substantially modified or produced by a large language model (LLM). Our maximum likelihood model leverages expert-written and AI-generated reference texts to accurately and efficiently examine real-world LLM-use at the corpus level. We apply this approach to a case study of scientific peer review in AI conferences that took place after the
Monitoring AI-Modified Content at Scale: A Case Study on the Impact of ChatGPT on AI Conference Peer Reviews
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cs.AI, q-bio.NC updates on arXiv.org
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TabTracer: Monte Carlo Tree Search for Complex Table Reasoning with Large Language Models
arXiv:2602.14089v1 Announce Type: cross Abstract: Large language models (LLMs) have emerged as powerful tools for natural language table reasoning, where there are two main categories of methods. Prompt-based approaches rely on language-only inference or one-pass program generation without step-level verification. Agent-based approaches use tools in a closed loop, but verification is often local and backtracking is limited, allowing errors to propagate and increasing cost. Moreover, they rely o
TabTracer: Monte Carlo Tree Search for Complex Table Reasoning with Large Language Models
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cs.AI, q-bio.NC updates on arXiv.org
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ShotFinder: Imagination-Driven Open-Domain Video Shot Retrieval via Web Search
arXiv:2601.23232v3 Announce Type: replace-cross Abstract: In recent years, large language models (LLMs) have made rapid progress in information retrieval, yet existing research has mainly focused on text or static multimodal settings. Open-domain video shot retrieval, which involves richer temporal structure and more complex semantics, still lacks systematic benchmarks and analysis. To fill this gap, we introduce ShotFinder, a benchmark that formalizes editing requirements as keyframe-oriented