Normal view
-
cs.AI, q-bio.NC updates on arXiv.org
-
BlueLM-GUI Technical Report: A Real-Device-Centric Flywheel for Self-Improving Mobile GUI Agents
arXiv:2609.12394v1 Announce Type: new Abstract: Mobile GUI agents are shifting from multi-module frameworks to native models trained end-to-end, yet industrial deployment faces three persistent gaps. Sandbox training produces a distribution mismatch with production environments; expensive real-device failures remain underutilized; and fixed benchmarks saturate, losing the power to guide iteration. We present BlueLM-GUI, a 35B-A3B mobile GUI agent built as a real-device-centric flywheel that clo
-
cs.AI, q-bio.NC updates on arXiv.org
-
Active Adaptation, Not Static Defense: Temporal Dynamics of Preventative Steering in Adversarial Fine-Tuning
arXiv:2609.10142v1 Announce Type: cross Abstract: Large language models remain fragile against malicious fine-tuning, motivating training-time defenses against harmful persona drift. Preventative Steering injects undesirable-trait persona vectors during fine-tuning and removes them at evaluation time, yet the mechanism behind its lasting protection remains unclear. Analyzing its temporal optimization dynamics, we find that the defense emerges from an early compensatory adaptation phase followed
Active Adaptation, Not Static Defense: Temporal Dynamics of Preventative Steering in Adversarial Fine-Tuning
-
cs.AI, q-bio.NC updates on arXiv.org
-
LightNav-0: Eliciting VLM Spatial Intelligence for Generalist Embodied Navigation
arXiv:2608.30935v2 Announce Type: replace-cross Abstract: Embodied navigation requires agents to translate heterogeneous goals and visual observations into actions across tasks, environments, and robot embodiments. Modern vision-language models (VLMs) already encode spatial priors for visual grounding, spatial reasoning, and pointing, but these capabilities are rarely elicited directly for robot control. Existing navigation systems instead rely on task- or embodiment-specific components, fragme
LightNav-0: Eliciting VLM Spatial Intelligence for Generalist Embodied Navigation
-
Pulmonary nodule
-
Pulmonary nodule prediction in the multi-omics era: Integrating radiomics, AI, liquid biopsy, and airway classifiers
Crit Rev Oncol Hematol. 2026 Sep;225:105483. doi: 10.1016/j.critrevonc.2026.105483. Epub 2026 Jul 10.ABSTRACTLow-dose CT (LDCT) lung cancer screening significantly reduces mortality but has dramatically increased the detection of pulmonary nodules. Most of these nodules are benign, leading to a high false-positive rate that triggers unnecessary invasive procedures and patient anxiety, underscoring the need for more precise noninvasive diagnostic tools. Critically, single-modality liquid biopsy b
Pulmonary nodule prediction in the multi-omics era: Integrating radiomics, AI, liquid biopsy, and airway classifiers
Crit Rev Oncol Hematol. 2026 Sep;225:105483. doi: 10.1016/j.critrevonc.2026.105483. Epub 2026 Jul 10.
ABSTRACT
Low-dose CT (LDCT) lung cancer screening significantly reduces mortality but has dramatically increased the detection of pulmonary nodules. Most of these nodules are benign, leading to a high false-positive rate that triggers unnecessary invasive procedures and patient anxiety, underscoring the need for more precise noninvasive diagnostic tools. Critically, single-modality liquid biopsy biomarkers, including circulating tumor cells, cell-free DNA mutations, or individual microRNAs, have demonstrated insufficient sensitivity or specificity for independent clinical deployment when used in isolation. This necessitates a paradigm shift toward multimodal molecular integration, wherein complementary biomarker classes are combined to overcome the inherent limitations of any single analyte. Traditional clinical prediction models (Mayo, VA, Brock, Herder) assist in estimating malignancy risk, yet their accuracy remains modest. Emerging approaches harness radiomics and artificial intelligence (AI) to extract high-dimensional imaging features from chest CT scans, improving risk stratification beyond human assessment alone. In parallel, minimally invasive liquid biopsy biomarkers offer complementary avenues to detect occult malignancy signals. Additionally, bronchial airway gene expression classifiers leverage the "field-of-injury" effect in normal respiratory epithelium to help identify lung cancer even when the nodule itself cannot be directly sampled via biopsy. Integrating these radiologic and molecular data streams into a multi-omics framework has the potential to enhance diagnostic precision for indeterminate pulmonary nodules, enabling more confident discrimination between benign and malignant lesions. However, most of these emerging tools have not yet been validated in large prospective trials and face technological barriers as well as challenges in real-world implementation. This review focuses primarily on LDCT screening detected pulmonary nodules, while incorporating evidence from incidentally detected and other indeterminate nodule cohorts when relevant to broader CT based management. By synthesizing advances in radiomics, AI, liquid biopsy, airway classifiers, and multi-omics integration, we highlight the need for prospective validation and multidisciplinary collaboration to translate these approaches into clinically useful pathways that improve early lung cancer detection, reduce unnecessary interventions, and enhance patient outcomes.
PMID:42431477 | DOI:10.1016/j.critrevonc.2026.105483
-
cs.AI, q-bio.NC updates on arXiv.org
-
NeurIPS: Neuro-anatomical Inductive Priors for Sphere-based Brain Decoding
arXiv:2605.24993v1 Announce Type: new Abstract: Current fMRI decoders face a performance-fidelity trade-off where efficient ID encoders outperform geometrically faithful surface-based models. We argue this is partly driven by inefficient surface tokenization and the failure to use anatomy as a predictive signal. We present NeurIPS, a framework that improves surface-based decoding by reframing anatomical variation from a nuisance to a powerful inductive prior. NeurIPS unites two innovations: a S
NeurIPS: Neuro-anatomical Inductive Priors for Sphere-based Brain Decoding
-
cs.AI, q-bio.NC updates on arXiv.org
-
AgentHijack: Benchmarking Computer Use Agent Robustness to Common Environment Corruptions
arXiv:2605.25707v1 Announce Type: new Abstract: Autonomous computer use agents that powered by multimodal large language models (MLLMs) are emerging as capable assistants for completing complex digital workflows. However, real-world execution environments are far from ideal: pop-ups, resolution changes, and competing applications frequently interfere with agent perception and control. We introduce AgentHijack, a benchmark designed to evaluate the robustness of computer-use agents under common c
AgentHijack: Benchmarking Computer Use Agent Robustness to Common Environment Corruptions
-
cs.AI, q-bio.NC updates on arXiv.org
-
EchoDistill:Alignment Noisy-to-Clean Self-Distillation for Robust Audio LLMs
arXiv:2605.23954v1 Announce Type: cross Abstract: Audio Large Language Models (ALLMs) are highly vulnerable to real-world noise, which often induces severe semantic drift and hallucinations. Existing robustness methods primarily rely on waveform-level acoustic enhancement, answer-level supervision, or the internal suppression of noise representations. To address these issues, we propose echodistill, an alignment-based noisy-to-clean self-distillation framework. Echodistill leverages a frozen cl
EchoDistill:Alignment Noisy-to-Clean Self-Distillation for Robust Audio LLMs
-
cs.AI, q-bio.NC updates on arXiv.org
-
When the Manual Lies: A Realistic Benchmark to Evaluate MCP Poisoning Attacks for LLM Agents
arXiv:2605.24069v1 Announce Type: cross Abstract: The rise of tool-using Large Language Model (LLM) agents, standardized by protocols like the Model Context Protocol (MCP), has unlocked unprecedented autonomous execution capabilities for LLM Agents by integrating external open-domain knowledge and tools. However, this interoperability introduces a covert attack surface targeting the agent's cognitive planning layer. This paper systematically investigates Tool Description Poisoning (TDP), a nove
When the Manual Lies: A Realistic Benchmark to Evaluate MCP Poisoning Attacks for LLM Agents
-
Omics In Lung
-
Multi-omics analysis of glutamine and fish collagen peptides in alleviating post-antibiotic Streptococcus pneumoniae injury in feline lung cells
Exp Ther Med. 2026 Mar 30;31(6):148. doi: 10.3892/etm.2026.13143. eCollection 2026 Jun.ABSTRACTStreptococcus pneumoniae (SP) infection often leads to persistent lung injury even after antibiotic treatment. Despite this phenomenon, the mechanisms underlying host cell recovery remain poorly understood. Upon breaching the epithelial barrier, SP primarily targets the pulmonary interstitial cells, which constitute the major mesenchymal component of the lung. These cells serve as essential effectors o
Multi-omics analysis of glutamine and fish collagen peptides in alleviating post-antibiotic Streptococcus pneumoniae injury in feline lung cells
Exp Ther Med. 2026 Mar 30;31(6):148. doi: 10.3892/etm.2026.13143. eCollection 2026 Jun.
ABSTRACT
Streptococcus pneumoniae (SP) infection often leads to persistent lung injury even after antibiotic treatment. Despite this phenomenon, the mechanisms underlying host cell recovery remain poorly understood. Upon breaching the epithelial barrier, SP primarily targets the pulmonary interstitial cells, which constitute the major mesenchymal component of the lung. These cells serve as essential effectors of tissue repair, extracellular matrix remodeling and epithelial restoration. Therefore, a feline pulmonary interstitial cell (FCA-L2) model of SP infection was established to investigate the protective effects of glutamine (GLU) and fish collagen peptides (FCP) through integrated transcriptomic and metabolomic analyses. Cells were infected with SP (0.05 McFarland units for 4 h) and then treated with doxycycline (7.5 µg/ml for 18 h) followed by GLU (40 mM) or FCP (500 µg/ml). Notably, SP infection increased lactate dehydrogenase (LDH) release by 3.5-fold, induced secretion of IL-1β, TNF-α and IL-8, disrupted tight-junction proteins (claudin, ZO-1 and occludin) and caused oxidative imbalance and apoptosis despite antibiotic (doxycycline) treatment. However, treatment with GLU or FCP significantly reduced LDH release by ~40%, restored junctional proteins, suppressed inflammatory cytokines and enhanced antioxidant enzyme activities. Multi-omics analysis revealed that GLU promoted amino acid biosynthesis and energy metabolism and suppressed aminoacyl-tRNA synthetases and cell-cycle regulators, thereby enhancing metabolic adaptability. By contrast, FCP activated amino and nucleotide sugar metabolism, increased polyunsaturated fatty-acid synthesis and supported glycocalyx repair and membrane reconstruction. GLU and FCP provided complementary metabolic and structural protection, which mitigated post-infectious stress and promoted cellular recovery. The findings of the present study underscore the potential of bioactive food-derived compounds as adjunctive therapies that may accelerate lung tissue repair and enhance the efficacy of conventional antibiotics.
PMID:41988354 | PMC:PMC13077270 | DOI:10.3892/etm.2026.13143
-
Oncogene - Issue - nature.com science feeds
-
Correction: Steroid receptor coactivator-1 facilitates METTL3-mediated m6A modification by coactivating NF-κB and promotes the malignant progression of glioblastoma
Oncogene, Published online: 15 April 2026; doi:10.1038/s41388-026-03788-8Correction: Steroid receptor coactivator-1 facilitates METTL3-mediated m6A modification by coactivating NF-κB and promotes the malignant progression of glioblastoma
Correction: Steroid receptor coactivator-1 facilitates METTL3-mediated m6A modification by coactivating NF-κB and promotes the malignant progression of glioblastoma
Oncogene, Published online: 15 April 2026; doi:10.1038/s41388-026-03788-8
Correction: Steroid receptor coactivator-1 facilitates METTL3-mediated m6A modification by coactivating NF-κB and promotes the malignant progression of glioblastoma-
(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
-
Effect of the Maxing Huoqiao granule on nonsevere community-acquired pneumonia: A multicenter, double-blind, placebo-controlled randomized trial
Pharmacol Res. 2026 Apr 9:108186. doi: 10.1016/j.phrs.2026.108186. Online ahead of print.ABSTRACTCommunity-acquired pneumonia (CAP) remains a major global public health challenge with substantial morbidity and mortality. Although preclinical studies suggest that Maxing Huoqiao (MXHQ) granule may have therapeutic potential for pneumonia, high-quality clinical evidence is still limited. We conducted a multicenter, double-blind, randomized, placebo-controlled trial at two tertiary hospitals in Chin
Effect of the Maxing Huoqiao granule on nonsevere community-acquired pneumonia: A multicenter, double-blind, placebo-controlled randomized trial
Pharmacol Res. 2026 Apr 9:108186. doi: 10.1016/j.phrs.2026.108186. Online ahead of print.
ABSTRACT
Community-acquired pneumonia (CAP) remains a major global public health challenge with substantial morbidity and mortality. Although preclinical studies suggest that Maxing Huoqiao (MXHQ) granule may have therapeutic potential for pneumonia, high-quality clinical evidence is still limited. We conducted a multicenter, double-blind, randomized, placebo-controlled trial at two tertiary hospitals in China to evaluate the clinical efficacy of MXHQ as adjunctive therapy and to explore its potential mechanisms in adults with nonsevere CAP receiving standard moxifloxacin treatment. A total of 96 patients were enrolled and randomized (1:1:1) to receive standard-dose MXHQ, low-dose MXHQ, or placebo in addition to moxifloxacin for 7 days, with a 14-day follow-up. The primary endpoint was clinical cure, defined as composite recovery of major respiratory symptoms, lung rales, and fever; secondary endpoints included symptom relief, radiographic improvement, and safety. Compared with placebo, standard-dose MXHQ was associated with a higher day-14 clinical cure rate (30.78% vs. 68.97%; RR = 0.45, 95% CI = 0.24-0.83; P < 0.01). Furthermore, the standard-dose intervention was correlated with a shorter time to relief and recovery of cough and sputum (P < 0.05), as well as improvements in symptom scores (P < 0.05) and promoting lesion absorption on chest CT (P < 0.05). Low-dose MXHQ showed no significant clinical benefit, whereas safety profiles were comparable across all groups. Transcriptomic analyses of peripheral blood mononuclear cells, complemented by a Streptococcus pneumonia animal model, indicated that the clinical benefits of MXHQ are linked to the modulation of inflammation and innate immunity. These omics and in vivo observations suggest a potential mechanism underlying the protective effects of MXHQ against inflammatory injury and promotion of tissue repair, involving the regulation of anti-inflammatory mediators and tissue repair-related factors. (Chictr.org.cn, ID Number: ChiCTR2400082095).
PMID:41966499 | DOI:10.1016/j.phrs.2026.108186
-
npj Digital Medicine
-
Graphicalized vision-language modeling for comprehensive lung nodule analysis and risk stratification
npj Digital Medicine, Published online: 11 April 2026; doi:10.1038/s41746-026-02602-9Graphicalized vision-language modeling for comprehensive lung nodule analysis and risk stratification
Graphicalized vision-language modeling for comprehensive lung nodule analysis and risk stratification
npj Digital Medicine, Published online: 11 April 2026; doi:10.1038/s41746-026-02602-9
Graphicalized vision-language modeling for comprehensive lung nodule analysis and risk stratification-
Nature - Issue - nature.com science feeds
-
Clinical application of base editing for treating β-thalassaemia
Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10342-9A clinical phase 1 trial of a single infusion of CS-101, CD34+ cells modified using a transformer base editor to reactivate fetal haemoglobin production, led to early and enduring transfusion independence in patients with β-thalassaemia.
Clinical application of base editing for treating β-thalassaemia
Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10342-9
A clinical phase 1 trial of a single infusion of CS-101, CD34+ cells modified using a transformer base editor to reactivate fetal haemoglobin production, led to early and enduring transfusion independence in patients with β-thalassaemia.-
cs.AI, q-bio.NC updates on arXiv.org
-
Combee: Scaling Prompt Learning for Self-Improving Language Model Agents
arXiv:2604.04247v1 Announce Type: new Abstract: Recent advances in prompt learning allow large language model agents to acquire task-relevant knowledge from inference-time context without parameter changes. For example, existing methods (like ACE or GEPA) can learn system prompts to improve accuracy based on previous agent runs. However, these methods primarily focus on single-agent or low-parallelism settings. This fundamentally limits their ability to efficiently learn from a large set of col
Combee: Scaling Prompt Learning for Self-Improving Language Model Agents
-
cs.AI, q-bio.NC updates on arXiv.org
-
StoryBlender: Inter-Shot Consistent and Editable 3D Storyboard with Spatial-temporal Dynamics
arXiv:2604.03315v1 Announce Type: cross Abstract: Storyboarding is a core skill in visual storytelling for film, animation, and games. However, automating this process requires a system to achieve two properties that current approaches rarely satisfy simultaneously: inter-shot consistency and explicit editability. While 2D diffusion-based generators produce vivid imagery, they often suffer from identity drift along with limited geometric control; conversely, traditional 3D animation workflows a
StoryBlender: Inter-Shot Consistent and Editable 3D Storyboard with Spatial-temporal Dynamics
-
cs.AI, q-bio.NC updates on arXiv.org
-
DIRECT: Video Mashup Creation via Hierarchical Multi-Agent Planning and Intent-Guided Editing
arXiv:2604.04875v1 Announce Type: cross Abstract: Video mashup creation represents a complex video editing paradigm that recomposes existing footage to craft engaging audio-visual experiences, demanding intricate orchestration across semantic, visual, and auditory dimensions and multiple levels. However, existing automated editing frameworks often overlook the cross-level multimodal orchestration to achieve professional-grade fluidity, resulting in disjointed sequences with abrupt visual transi
DIRECT: Video Mashup Creation via Hierarchical Multi-Agent Planning and Intent-Guided Editing
-
cs.AI, q-bio.NC updates on arXiv.org
-
TSPO: Breaking the Double Homogenization Dilemma in Multi-turn Search Policy Optimization
arXiv:2601.22776v2 Announce Type: replace Abstract: Multi-turn tool-integrated reasoning enables Large Language Models (LLMs) to solve complex tasks through iterative information retrieval. However, current reinforcement learning (RL) frameworks for search-augmented reasoning predominantly rely on sparse outcome-level rewards, leading to a "Double Homogenization Dilemma." This manifests as (1) Process homogenization, where the thinking, reasoning, and tooling involved in generation are ignored.
TSPO: Breaking the Double Homogenization Dilemma in Multi-turn Search Policy Optimization
-
cs.AI, q-bio.NC updates on arXiv.org
-
Talk to Right Specialists: Iterative Routing in Multi-agent Systems for Question Answering
arXiv:2501.07813v2 Announce Type: replace-cross Abstract: Retrieval-augmented generation (RAG) agents are increasingly deployed to answer questions over local knowledge bases that cannot be centralized due to knowledge-sovereignty constraints. This results in two recurring failures in production: users do not know which agent to consult, and complex questions require evidence distributed across multiple agents. To overcome these challenges, we propose RIRS, a training-free orchestration framewo
Talk to Right Specialists: Iterative Routing in Multi-agent Systems for Question Answering
-
cs.AI, q-bio.NC updates on arXiv.org
-
VLA Models Are More Generalizable Than You Think: Revisiting Physical and Spatial Modeling
arXiv:2512.02902v2 Announce Type: replace-cross Abstract: Vision-language-action (VLA) models achieve strong in-distribution performance but degrade sharply under novel camera viewpoints and visual perturbations. We show that this brittleness primarily arises from misalignment in Spatial Modeling, rather than Physical Modeling. To address this, we propose a one-shot adaptation framework that recalibrates visual representations through lightweight, learnable updates. Our first method, Feature To
VLA Models Are More Generalizable Than You Think: Revisiting Physical and Spatial Modeling
-
Nature Biotechnology - Issue - nature.com science feeds
-
Mirror-enhanced 4Pi-SMLM with one objective enables isotropic nanoscale imaging
Nature Biotechnology, Published online: 31 March 2026; doi:10.1038/s41587-026-03083-7Single-molecule 4Pi microscopy is simplified and made accessible by using a single objective.
Mirror-enhanced 4Pi-SMLM with one objective enables isotropic nanoscale imaging
Nature Biotechnology, Published online: 31 March 2026; doi:10.1038/s41587-026-03083-7
Single-molecule 4Pi microscopy is simplified and made accessible by using a single objective.