❌

Normal view

Received today — 7 October 2026 ⏭

Inositol Metabolism Modulates Inflammatory Injury in Acute Pancreatitis via the ISYNA1-NETs Axis

✇(Multiomics OR Omics) AND (Pancreatic)
By: Fei Han · Xinyi Liu · Yinghong Fan · Lin Chen · Xiaolei Shi · Yaning Wang · Weiming Xiao · Guotao Lu · Keyan Wu · Tianqi Xia · Jinqiang Zhuang · Runfeng Sun
27 September 2026 at 18:00

J Inflamm Res. 2026 Sep 22;19:606503. doi: 10.2147/JIR.S606503. eCollection 2026.

ABSTRACT

BACKGROUND: Neutrophil extracellular traps (NETs) were key factors mediating inflammatory injury in acute pancreatitis (AP). To this end, there was an urgent need to identify precise and effective therapeutic targets that modulate NETs formation, providing new ideas for the prevention and treatment of AP pancreatitis injury.

GAP: To address this gap, we investigated the potential involvement of the myo-inositol metabolism in modulating NETs and inflammatory damage during AP.

METHODS: Multi-omics analysis identified myo-inositol metabolism as critical. We then established the in vitro NETs model using phorbol-12-myristate-13-acetate (PMA) to investigate the role and regulatory mechanism of inositol-3-phosphate synthase 1 (ISYNA1) on NETs formation. Finally, the findings were validated in the classic AP mouse model to verify the correlation between myo-inositol metabolism and AP pathogenesis.

RESULTS: Multiple omics analyses showed that the myo-inositol metabolic pathway is the most significant, and the key enzyme ISYNA1 involved in myo-inositol synthesis was significantly reduced. ISYNA1 was significantly downregulated in both the in vitro NETs model and in neutrophils infiltrating the pancreatic tissue of AP mice. Meanwhile, exogenous supplementation of ISYNA1 or myo-inositol significantly inhibited the NETs formation in vitro and inflammatory injury in AP mice. Mechanistically, downregulation of ISYNA1 led to reduced myo-inositol synthesis, thereby promoting NETs formation via modulation of the PI3K/AKT pathway.

CONCLUSION: ISYNA1 and myo-inositol metabolism were among the key links that regulated NETs formation and inflammatory injury in AP. Therefore, enhancing ISYNA1 and myo-inositol metabolism might serve as a potential intervention target for treating acute organ injury in AP.

PMID:42801157 | PMC:PMC13615823 | DOI:10.2147/JIR.S606503

Received — 10 September 2026 ⏭

DHCR24<sup>+</sup> tumor epithelial cells drive cisplatin resistance in bladder cancer by enhancing cholesterol metabolism to activate lipid raft-associated MAPK signaling

✇Oncogene - Issue - nature.com science feeds
By: Yuanqiao Zhao · Zhuo Xing · Mengmeng Wang · Liangmin Fu · Ruilin Liu · Zexian Ding · Yuan Li · Yinhuai Wang · Bin Yan · Xueqiang Zhu
29 August 2026 at 08:00

Oncogene, Published online: 29 August 2026; doi:10.1038/s41388-026-03967-7

DHCR24+ tumor epithelial cells drive cisplatin resistance in bladder cancer by enhancing cholesterol metabolism to activate lipid raft-associated MAPK signaling
Received — 2 April 2026 ⏭

LG-HCC: Local Geometry-Aware Hierarchical Context Compression for 3D Gaussian Splatting

✇cs.AI, q-bio.NC updates on arXiv.org
By: Xuan Deng · Xiandong Meng · Hengyu Man · Qiang Zhu · Tiange Zhang · Debin Zhao · Xiaopeng Fan
1 April 2026 at 12:00
arXiv:2603.28431v2 Announce Type: replace-cross Abstract: Although 3D Gaussian Splatting (3DGS) enables high-fidelity real-time rendering, its prohibitive storage overhead severely hinders practical deployment. Recent anchor-based 3DGS compression schemes reduce gaussina redundancy through ome advanced context models. However, overlook explicit geometric dependencies, leading to structural degradation and suboptimal rate-distortion performance. In this paper, we propose LG-HCC, a geometry-aware 3DGS compression framework that incorporates inter-anchor geometric correlations into anchor pruning and entropy coding for compact representation. Specifically, we introduce an Neighborhood-Aware Anchor Pruning (NAAP) strategy, which evaluates anchor importance via weighted neighborhood feature aggregation and merges redundant anchors into salient neighbors, yielding a compact yet geometry-consistent anchor set. Building upon this optimized structure, we further develop a hierarchical entropy coding scheme, in which coarse-to-fine priors are exploited through a lightweight Geometry-Guided Convolution (GG-Conv) operator to enable spatially adaptive context modeling and rate-distortion optimization. Extensive experiments demonstrate that LG-HCC effectively resolves the structure preservation bottleneck, maintaining superior geometric integrity and rendering fidelity over state-of-the-art anchor-based compression approaches.
Received — 17 March 2026 ⏭

Variation-aware Flexible 3D Gaussian Editing

✇cs.AI, q-bio.NC updates on arXiv.org
By: Hao Qin · Yukai Sun · Meng Wang · Ming Kong · Mengxu Lu · Qiang Zhu
16 March 2026 at 12:00
arXiv:2602.11638v3 Announce Type: replace-cross Abstract: Indirect editing methods for 3D Gaussian Splatting (3DGS) have recently witnessed significant advancements. These approaches operate by first applying edits in the rendered 2D space and subsequently projecting the modifications back into 3D. However, this paradigm inevitably introduces cross-view inconsistencies and constrains both the flexibility and efficiency of the editing process. To address these challenges, we present VF-Editor, which enables native editing of Gaussian primitives by predicting attribute variations in a feedforward manner. To accurately and efficiently estimate these variations, we design a novel variation predictor distilled from 2D editing knowledge. The predictor encodes the input to generate a variation field and employs two learnable, parallel decoding functions to iteratively infer attribute changes for each 3D Gaussian. Thanks to its unified design, VF-Editor can seamlessly distill editing knowledge from diverse 2D editors and strategies into a single predictor, allowing for flexible and effective knowledge transfer into the 3D domain. Extensive experiments on both public and private datasets reveal the inherent limitations of indirect editing pipelines and validate the effectiveness and flexibility of our approach.
There are no more articles
❌