Normal view
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Molecular Therapy
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Lineage-specific pulmonary transcriptome landscape of coronavirus infection unveils universal immunotherapy for viral pneumonia
In the infection courses of different SARS-CoV-2 variants, disease outcomes and signatures were delineated by physiological changes, viral load, pathology, and pulmonary transcriptome analysis. This multi-dimensional landscape of disease outcomes and underlying mechanisms might provide important clues for immunotherapy of SARS-CoV-2 infection and pneumonia caused by other respiratory viruses.
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Oncogene - Issue - nature.com science feeds
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SRSF10 promotes cisplatin resistance in bladder cancer via BIN1 Exon 12 retention and ANXA1 activation
Oncogene, Published online: 06 April 2026; doi:10.1038/s41388-026-03735-7SRSF10 promotes cisplatin resistance in bladder cancer via BIN1 Exon 12 retention and ANXA1 activation
SRSF10 promotes cisplatin resistance in bladder cancer via BIN1 Exon 12 retention and ANXA1 activation
Oncogene, Published online: 06 April 2026; doi:10.1038/s41388-026-03735-7
SRSF10 promotes cisplatin resistance in bladder cancer via BIN1 Exon 12 retention and ANXA1 activation-
cs.AI, q-bio.NC updates on arXiv.org
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Predicting Neuromodulation Outcome for Parkinson's Disease with Generative Virtual Brain Model
arXiv:2603.29176v1 Announce Type: new Abstract: Parkinson's disease (PD) affects over ten million people worldwide. Although temporal interference (TI) and deep brain stimulation (DBS) are promising therapies, inter-individual variability limits empirical treatment selection, increasing non-negligible surgical risk and cost. Previous explorations either resort to limited statistical biomarkers that are insufficient to characterize variability, or employ AI-driven methods which is prone to overf
Predicting Neuromodulation Outcome for Parkinson's Disease with Generative Virtual Brain Model
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cs.AI, q-bio.NC updates on arXiv.org
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Towards Explainable Stakeholder-Aware Requirements Prioritisation in Aged-Care Digital Health
arXiv:2603.29114v1 Announce Type: cross Abstract: Requirements engineering for aged-care digital health must account for human aspects, because requirement priorities are shaped not only by technical functionality but also by stakeholders' health conditions, socioeconomics, and lived experience. Knowing which human aspects matter most, and for whom, is critical for inclusive and evidence-based requirements prioritisation. Yet in practice, while some studies have examined human aspects in RE, th
Towards Explainable Stakeholder-Aware Requirements Prioritisation in Aged-Care Digital Health
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Omics In Lung
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Integrative Multi-omics Analysis of Buti Huatan Tang in Chronic Obstructive Pulmonary Disease
J Vis Exp. 2026 Mar 13;(229). doi: 10.3791/70383.ABSTRACTThis study utilized a multi-omics and computational biology framework to investigate the therapeutic potential of the Traditional Chinese Medicine (TCM) formula Buti Huatan Tang (BTHTT) against chronic obstructive pulmonary disease (COPD). Significant physiological improvements were observed in a rat model following BTHTT intervention. Histological analysis showed a reversal of lung pathological damage, while biochemical assays, and transc
Integrative Multi-omics Analysis of Buti Huatan Tang in Chronic Obstructive Pulmonary Disease
J Vis Exp. 2026 Mar 13;(229). doi: 10.3791/70383.
ABSTRACT
This study utilized a multi-omics and computational biology framework to investigate the therapeutic potential of the Traditional Chinese Medicine (TCM) formula Buti Huatan Tang (BTHTT) against chronic obstructive pulmonary disease (COPD). Significant physiological improvements were observed in a rat model following BTHTT intervention. Histological analysis showed a reversal of lung pathological damage, while biochemical assays, and transcriptomics confirmed the normalization of IL-1β and IL-1R2 levels. Additionally, metabolic profiling revealed that BTHTT corrected disruptions in T3 and T4 thyroid hormone levels. A negative correlation was observed between the IL-1β/IL-1R2 axis and these thyroid hormones, indicating that their regulation is associated with the formula's therapeutic effect. Beyond direct measurements, machine learning algorithms identified ten COPD signature genes from clinical databases. Pathway enrichment analysis suggests that BTHTT may act through cytokine-cytokine-receptor interactions and thyroid hormone synthesis pathways. Furthermore, while 283 components were identified in vivo, compounds such as tanshinone IIA and cryptotanshinone are currently considered candidate active substances. Their role as primary drivers is supported by a model in which they stably bind to IL-1R2; this inference is based on molecular docking and molecular dynamics (MD) simulations rather than direct experimental isolation. Overall, the data support a model in which BTHTT exerts a multi-target effect on COPD by modulating inflammation and metabolic homeostasis. This integrated approach provides a refined scientific basis for the clinical application of BTHTT and highlights specific pathways for future experimental validation.
PMID:41911070 | DOI:10.3791/70383
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(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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Integrative Multi-omics Analysis of Buti Huatan Tang in Chronic Obstructive Pulmonary Disease
J Vis Exp. 2026 Mar 13;(229). doi: 10.3791/70383.ABSTRACTThis study utilized a multi-omics and computational biology framework to investigate the therapeutic potential of the Traditional Chinese Medicine (TCM) formula Buti Huatan Tang (BTHTT) against chronic obstructive pulmonary disease (COPD). Significant physiological improvements were observed in a rat model following BTHTT intervention. Histological analysis showed a reversal of lung pathological damage, while biochemical assays, and transc
Integrative Multi-omics Analysis of Buti Huatan Tang in Chronic Obstructive Pulmonary Disease
J Vis Exp. 2026 Mar 13;(229). doi: 10.3791/70383.
ABSTRACT
This study utilized a multi-omics and computational biology framework to investigate the therapeutic potential of the Traditional Chinese Medicine (TCM) formula Buti Huatan Tang (BTHTT) against chronic obstructive pulmonary disease (COPD). Significant physiological improvements were observed in a rat model following BTHTT intervention. Histological analysis showed a reversal of lung pathological damage, while biochemical assays, and transcriptomics confirmed the normalization of IL-1β and IL-1R2 levels. Additionally, metabolic profiling revealed that BTHTT corrected disruptions in T3 and T4 thyroid hormone levels. A negative correlation was observed between the IL-1β/IL-1R2 axis and these thyroid hormones, indicating that their regulation is associated with the formula's therapeutic effect. Beyond direct measurements, machine learning algorithms identified ten COPD signature genes from clinical databases. Pathway enrichment analysis suggests that BTHTT may act through cytokine-cytokine-receptor interactions and thyroid hormone synthesis pathways. Furthermore, while 283 components were identified in vivo, compounds such as tanshinone IIA and cryptotanshinone are currently considered candidate active substances. Their role as primary drivers is supported by a model in which they stably bind to IL-1R2; this inference is based on molecular docking and molecular dynamics (MD) simulations rather than direct experimental isolation. Overall, the data support a model in which BTHTT exerts a multi-target effect on COPD by modulating inflammation and metabolic homeostasis. This integrated approach provides a refined scientific basis for the clinical application of BTHTT and highlights specific pathways for future experimental validation.
PMID:41911070 | DOI:10.3791/70383