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Integrative fragmentomic and mutational signature profile of plasma cfDNA for early lung cancer detection

15 April 2026 at 18:00

NPJ Precis Oncol. 2026 Apr 15. doi: 10.1038/s41698-026-01416-y. Online ahead of print.

ABSTRACT

Detecting lung cancer effectively in the general population is essential for optimizing treatment outcomes and improving the 5-year survival rate. While low-dose computed tomography (LDCT) is the current standard, it has limitations in broader populations. We developed a blood-based multi-omics model using whole-genome cell-free DNA (cfDNA) features to distinguish lung cancer from non-cancer individuals. This study included 1600 patients and an equal number of non-cancer controls, divided into training and validation cohorts. The model achieved an area under the curve (AUC) of 95.59% for the training cohort and 95.74% for the validation cohort. The model consistently performed well across various cancer stages and histological subtypes. To further validate the performance of the model, an external validation cohort was utilized. Notably, it also effectively differentiated non-cancer samples from cancer samples in the external validation cohort, with 85.9% sensitivity and 94.78% specificity. Importantly, in simulated population screenings, our ctDNA assay outperformed both LDCT and a previously established method. This suggests its potential utility in wider lung cancer screening programs, possibly complementing the LDCT approach. In conclusion, our ctDNA assay emerges as a promising and highly sensitive tool for the early detection and categorization of lung cancer.

PMID:41986614 | DOI:10.1038/s41698-026-01416-y

Multimodal Laryngoscopic Video Analysis for Assisted Diagnosis of Vocal Fold Paralysis

arXiv:2409.03597v4 Announce Type: replace-cross Abstract: This paper presents the Multimodal Laryngoscopic Video Analyzing System (MLVAS), a novel system that leverages both audio and video data to automatically extract key video segments and metrics from raw laryngeal videostroboscopic videos for assisted clinical assessment. The system integrates video-based glottis detection with an audio keyword spotting method to analyze both video and audio data, identifying patient vocalizations and refining video highlights to ensure optimal inspection of vocal fold movements. Beyond key video segment extraction from the raw laryngeal videos, MLVAS is able to generate effective audio and visual features for Vocal Fold Paralysis (VFP) detection. Pre-trained audio encoders are utilized to encode the patient voice to get the audio features. Visual features are generated by measuring the angle deviation of both the left and right vocal folds to the estimated glottal midline on the segmented glottis masks. To get better masks, we introduce a diffusion-based refinement that follows traditional U-Net segmentation to reduce false positives. We conducted several ablation studies to demonstrate the effectiveness of each module and modalities in the proposed MLVAS. The experimental results on a public segmentation dataset show the effectiveness of our proposed segmentation module. In addition, unilateral VFP classification results on a real-world clinic dataset demonstrate MLVAS's ability of providing reliable and objective metrics as well as visualization for assisted clinical diagnosis.

Descent-Guided Policy Gradient for Scalable Cooperative Multi-Agent Learning

24 February 2026 at 13:00
arXiv:2602.20078v1 Announce Type: cross Abstract: Scaling cooperative multi-agent reinforcement learning (MARL) is fundamentally limited by cross-agent noise: when agents share a common reward, the actions of all $N$ agents jointly determine each agent's learning signal, so cross-agent noise grows with $N$. In the policy gradient setting, per-agent gradient estimate variance scales as $\Theta(N)$, yielding sample complexity $\mathcal{O}(N/\epsilon)$. We observe that many domains -- cloud computing, transportation, power systems -- have differentiable analytical models that prescribe efficient system states. In this work, we propose Descent-Guided Policy Gradient (DG-PG), a framework that constructs noise-free per-agent guidance gradients from these analytical models, decoupling each agent's gradient from the actions of all others. We prove that DG-PG reduces gradient variance from $\Theta(N)$ to $\mathcal{O}(1)$, preserves the equilibria of the cooperative game, and achieves agent-independent sample complexity $\mathcal{O}(1/\epsilon)$. On a heterogeneous cloud scheduling task with up to 200 agents, DG-PG converges within 10 episodes at every tested scale -- from $N=5$ to $N=200$ -- directly confirming the predicted scale-invariant complexity, while MAPPO and IPPO fail to converge under identical architectures.
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