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cs.AI, q-bio.NC updates on arXiv.org
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The Menu Is an Execution Prior: State-Path Tool Menus for Online Agents
arXiv:2609.09395v1 Announce Type: new Abstract: Language models act through tools, yet practical agents face libraries containing thousands of interfaces. We introduce the tool menu as the short, ordered subset of available tools shown to an agent before execution. The agent can call only tools in this menu. Multi-step tasks require the final action and the prerequisite tools that create its inputs in a usable order. Current constructors rank tools by request relevance, which can surface the fi
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cs.AI, q-bio.NC updates on arXiv.org
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Detecting Unfaithful Chain-of-Thought via Circuit-Guided Internal-External Discrepancy
arXiv:2605.25603v1 Announce Type: new Abstract: Chain-of-thought (CoT) reasoning improves the problem-solving ability of large language models (LLMs), but generated reasoning traces may not faithfully reflect the model's actual decision process. Existing CoT unfaithfulness detectors mainly rely on external signals from generated rationales, such as textual plausibility or answer consistency, while overlooking evidence from the model's internal computation. Although recent circuit tracing method
Detecting Unfaithful Chain-of-Thought via Circuit-Guided Internal-External Discrepancy
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cs.AI, q-bio.NC updates on arXiv.org
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LiveMCP-101: Stress Testing and Diagnosing MCP-enabled Agents on Challenging Queries
arXiv:2508.15760v2 Announce Type: replace-cross Abstract: Tool calling has emerged as a critical capability for AI agents. In contrast to conventional tool calling frameworks that rely on static, provider-specific tool definitions, the Model Context Protocol (MCP) offers a unified interface to discover and invoke tools dynamically. However, there is a significant gap in benchmarking multi-step tasks using diverse MCP tools in realistic, dynamic scenarios. In this work, we present LiveMCP-101, a
LiveMCP-101: Stress Testing and Diagnosing MCP-enabled Agents on Challenging Queries
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Omics In Lung
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Integrative fragmentomic and mutational signature profile of plasma cfDNA for early lung cancer detection
NPJ Precis Oncol. 2026 Apr 15. doi: 10.1038/s41698-026-01416-y. Online ahead of print.ABSTRACTDetecting lung cancer effectively in the general population is essential for optimizing treatment outcomes and improving the 5-year survival rate. While low-dose computed tomography (LDCT) is the current standard, it has limitations in broader populations. We developed a blood-based multi-omics model using whole-genome cell-free DNA (cfDNA) features to distinguish lung cancer from non-cancer individuals
Integrative fragmentomic and mutational signature profile of plasma cfDNA for early lung cancer detection
NPJ Precis Oncol. 2026 Apr 15. doi: 10.1038/s41698-026-01416-y. Online ahead of print.
ABSTRACT
Detecting lung cancer effectively in the general population is essential for optimizing treatment outcomes and improving the 5-year survival rate. While low-dose computed tomography (LDCT) is the current standard, it has limitations in broader populations. We developed a blood-based multi-omics model using whole-genome cell-free DNA (cfDNA) features to distinguish lung cancer from non-cancer individuals. This study included 1600 patients and an equal number of non-cancer controls, divided into training and validation cohorts. The model achieved an area under the curve (AUC) of 95.59% for the training cohort and 95.74% for the validation cohort. The model consistently performed well across various cancer stages and histological subtypes. To further validate the performance of the model, an external validation cohort was utilized. Notably, it also effectively differentiated non-cancer samples from cancer samples in the external validation cohort, with 85.9% sensitivity and 94.78% specificity. Importantly, in simulated population screenings, our ctDNA assay outperformed both LDCT and a previously established method. This suggests its potential utility in wider lung cancer screening programs, possibly complementing the LDCT approach. In conclusion, our ctDNA assay emerges as a promising and highly sensitive tool for the early detection and categorization of lung cancer.
PMID:41986614 | DOI:10.1038/s41698-026-01416-y
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Oncogene - Issue - nature.com science feeds
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Strand-asymmetric G-runs and G4s downstream of TSS modulate tumor suppressor gene transcription
Oncogene, Published online: 02 April 2026; doi:10.1038/s41388-026-03761-5Strand-asymmetric G-runs and G4s downstream of TSS modulate tumor suppressor gene transcription
Strand-asymmetric G-runs and G4s downstream of TSS modulate tumor suppressor gene transcription
Oncogene, Published online: 02 April 2026; doi:10.1038/s41388-026-03761-5
Strand-asymmetric G-runs and G4s downstream of TSS modulate tumor suppressor gene transcription-
cs.AI, q-bio.NC updates on arXiv.org
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ELLMob: Event-Driven Human Mobility Generation with Self-Aligned LLM Framework
arXiv:2603.07946v1 Announce Type: cross Abstract: Human mobility generation aims to synthesize plausible trajectory data, which is widely used in urban system research. While Large Language Model-based methods excel at generating routine trajectories, they struggle to capture deviated mobility during large-scale societal events. This limitation stems from two critical gaps: (1) the absence of event-annotated mobility datasets for design and evaluation, and (2) the inability of current framework
ELLMob: Event-Driven Human Mobility Generation with Self-Aligned LLM Framework
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cs.AI, q-bio.NC updates on arXiv.org
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CM2: Reinforcement Learning with Checklist Rewards for Multi-Turn and Multi-Step Agentic Tool Use
arXiv:2602.12268v2 Announce Type: replace Abstract: AI agents are increasingly used to solve real-world tasks by reasoning over multi-turn user interactions and invoking external tools. However, applying reinforcement learning to such settings remains difficult: realistic objectives often lack verifiable rewards and instead emphasize open-ended behaviors; moreover, RL for multi-turn, multi-step agentic tool use is still underexplored; and building and maintaining executable tool environments is
CM2: Reinforcement Learning with Checklist Rewards for Multi-Turn and Multi-Step Agentic Tool Use
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cs.AI, q-bio.NC updates on arXiv.org
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RewardMap: Tackling Sparse Rewards in Fine-grained Visual Reasoning via Multi-Stage Reinforcement Learning
arXiv:2510.02240v2 Announce Type: replace-cross Abstract: Fine-grained visual reasoning remains a core challenge for multimodal large language models (MLLMs). The recently introduced ReasonMap highlights this gap by showing that even advanced MLLMs struggle with spatial reasoning in structured and information-rich settings such as transit maps, a task of clear practical and scientific importance. However, standard reinforcement learning (RL) on such tasks is impeded by sparse rewards and unstab
RewardMap: Tackling Sparse Rewards in Fine-grained Visual Reasoning via Multi-Stage Reinforcement Learning
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cs.AI, q-bio.NC updates on arXiv.org
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Privacy-Concealing Cooperative Perception for BEV Scene Segmentation
arXiv:2602.13555v1 Announce Type: cross Abstract: Cooperative perception systems for autonomous driving aim to overcome the limited perception range of a single vehicle by communicating with adjacent agents to share sensing information. While this improves perception performance, these systems also face a significant privacy-leakage issue, as sensitive visual content can potentially be reconstructed from the shared data. In this paper, we propose a novel Privacy-Concealing Cooperation (PCC) fra