Oncogene, Published online: 04 October 2026; doi:10.1038/s41388-026-04002-5

KDM4A drives TGCT metastasis by inducing focal adhesion disassembly via STAT1-mediated CCL3 transcriptional activation

arXiv:2603.29418v1 Announce Type: cross Abstract: Although multimodal large language models (MLLMs) are increasingly deployed in real-world applications, their instruction-following behavior leaves them vulnerable to prompt injection attacks. Existing prompt injection methods predominantly rely on textual prompts or perceptible visual prompts that are observable by human users. In this work, we study imperceptible visual prompt injection against powerful closed-source MLLMs, where adversarial instructions are embedded in the visual modality. Our method adaptively embeds the malicious prompt into the input image via a bounded text overlay to provide semantic guidance. Meanwhile, the imperceptible visual perturbation is iteratively optimized to align the feature representation of the attacked image with those of the malicious visual and textual targets at both coarse- and fine-grained levels. Specifically, the visual target is instantiated as a text-rendered image and progressively refined during optimization to more faithfully represent the desired semantics and improve transferability. Extensive experiments on two multimodal understanding tasks across multiple closed-source MLLMs demonstrate the superior performance of our approach compared to existing methods.

arXiv:2603.22829v1 Announce Type: new Abstract: With the rapid development and widespread application of Large Language Models (LLMs), their potential safety risks have attracted widespread attention. Reinforcement Learning from Human Feedback (RLHF) has been adopted to enhance the safety performance of LLMs. As a simple and effective alternative to RLHF, Direct Preference Optimization (DPO) is widely used for safety alignment. However, safety alignment still suffers from severe overfitting, which limits its actual performance. This paper revisits the overfitting phenomenon from the perspective of the model's comprehension of the training data. We find that the Imbalanced Preference Comprehension phenomenon exists between responses in preference pairs, which compromises the model's safety performance. To address this, we propose Balanced Direct Preference Optimization (B-DPO), which adaptively modulates optimization strength between preferred and dispreferred responses based on mutual information. A series of experimental results show that B-DPO can enhance the safety capability while maintaining the competitive general capabilities of LLMs on various mainstream benchmarks compared to state-of-the-art methods. \color{red}{Warning: This paper contains examples of harmful texts, and reader discretion is recommended.