Normal view
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cs.AI, q-bio.NC updates on arXiv.org
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Tracing and Coordinating Cross-Layer Influence for Multimodal Model Merging
arXiv:2609.12897v1 Announce Type: new Abstract: Multimodal model merging aims to consolidate task experts into a single model that retains their complementary capabilities. Most unimodal model merging methods combine expert updates within individual layers, and multimodal approaches largely follow this design. However, an expert update changes the representations passed to subsequent layers, allowing its influence to propagate across depth and affect how visual and textual information interact.
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cs.AI, q-bio.NC updates on arXiv.org
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Behavior Quotient Learning for Low-Rank Adaptation of LLM Agents
arXiv:2609.12896v1 Announce Type: cross Abstract: LLM-based agents rely on heterogeneous interaction capabilities to accomplish complex tasks. Existing approaches often distribute these capabilities across multiple LoRA adapters, which increases adapter storage requirements and introduces routing overhead during inference. A single LoRA avoids this overhead, but learning from diverse agent trajectories under a fixed rank budget presents two challenges. First, trajectories with different interac
Behavior Quotient Learning for Low-Rank Adaptation of LLM Agents
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cs.AI, q-bio.NC updates on arXiv.org
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CityPlanner: A Sandbox Agent for Executable Urban Planning
arXiv:2609.09578v1 Announce Type: new Abstract: Urban planning is a real-world spatial optimization problem that requires selecting feasible actions from large candidate spaces under practical objectives such as cost and service quality. Existing optimization and reinforcement learning methods are effective for fixed formulations, but often depend on task-specific representations and constraint handling. We propose \emph{CityPlanner}, a sandbox-agent framework for executable urban planning. Cit
CityPlanner: A Sandbox Agent for Executable Urban Planning
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cs.AI, q-bio.NC updates on arXiv.org
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KernelGenBench: Can LLMs and Agents Write Efficient Kernels Across Operator Sources and Hardware Platforms?
arXiv:2607.27231v3 Announce Type: replace Abstract: Modern AI systems depend on specialized accelerator kernels, whose development is complicated by increasingly diverse operators and hardware. LLMs and agentic systems promise to automate this work, but existing evaluations do not show whether their performance transfers across operator sources and hardware platforms, or what such transfer costs. We present KernelGenBench, the first unified multi-source and multi-chip infrastructure for evaluat
KernelGenBench: Can LLMs and Agents Write Efficient Kernels Across Operator Sources and Hardware Platforms?
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Nature - Issue - nature.com science feeds
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Author Correction: A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution
Nature, Published online: 07 September 2026; doi:10.1038/s41586-026-11094-2Author Correction: A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution
Author Correction: A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution
Nature, Published online: 07 September 2026; doi:10.1038/s41586-026-11094-2
Author Correction: A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution-
Oncogene - Issue - nature.com science feeds
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The RNA-binding protein La/SSB is associated with HNSCC progression and TFAP2C/FSCN1-linked transcriptional regulation
Oncogene, Published online: 03 September 2026; doi:10.1038/s41388-026-03959-7The RNA-binding protein La/SSB is associated with HNSCC progression and TFAP2C/FSCN1-linked transcriptional regulation
The RNA-binding protein La/SSB is associated with HNSCC progression and TFAP2C/FSCN1-linked transcriptional regulation
Oncogene, Published online: 03 September 2026; doi:10.1038/s41388-026-03959-7
The RNA-binding protein La/SSB is associated with HNSCC progression and TFAP2C/FSCN1-linked transcriptional regulation-
Omics in Hepatocellular
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ATIC Promotes LIHC Progression and Serves as an Independent Prognostic Marker: A Pan-cancer Transcriptomic Analysis
Curr Mol Med. 2026 May 11. doi: 10.2174/0115665240438824260113042223. Online ahead of print.ABSTRACTBACKGROUND: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/ IMP cyclohydrolase(ATIC) is a 64-kDa bifunctional enzyme, 5-aminoimidazole- 4-carboxamide ribonucleotide formyltransferase (AICART) and IMP cyclohydrolase, respectively. catalyzes the last two steps of the purine ab initio biosynthetic pathway. ATIC has been implicated in cancer progression, but its pan-cancer profile and
ATIC Promotes LIHC Progression and Serves as an Independent Prognostic Marker: A Pan-cancer Transcriptomic Analysis
Curr Mol Med. 2026 May 11. doi: 10.2174/0115665240438824260113042223. Online ahead of print.
ABSTRACT
BACKGROUND: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/ IMP cyclohydrolase(ATIC) is a 64-kDa bifunctional enzyme, 5-aminoimidazole- 4-carboxamide ribonucleotide formyltransferase (AICART) and IMP cyclohydrolase, respectively. catalyzes the last two steps of the purine ab initio biosynthetic pathway. ATIC has been implicated in cancer progression, but its pan-cancer profile and specific prognostic utility in liver hepatocellular carcinoma (LIHC) remain incompletely defined.
METHODS: We analyzed TCGA RNA-seq data across 33 tumor types to assess ATIC expression, diagnostic performance (ROC/AUC), and prognostic associations (OS, DSS, PFI). We correlated ATIC expression with immune infiltration, TMB, MSI, and predicted neoantigen load, and constructed a LIHC-specific prognostic nomogram integrating ATIC and clinicopathologic features. Enrichment analyses (STRING, GO/KEGG, GSEA) and pharmacogenomic correlations (GDSC, CTRP) were performed to explore mechanisms and drug sensitivities.
RESULTS: ATIC was significantly upregulated in 16 tumor types, including LIHC (p<0.001). Pan-cancer ROC analyses showed high diagnostic accuracy in several cancers (examples: CHOL AUC=1.000, LIHC AUC=0.936, LUAD AUC=0.947). High ATIC expression associated with poorer OS in ACC, HNSC, LIHC, and PAAD (eg, LIHC: HR=1.39(1.04-1.85), p=0.028). In LIHC, ATIC correlated with advanced T stage, higher grade, elevated AFP, and shorter OS. Multivariable Cox regression identified ATIC expression and pathological T stage as independent predictors; time-dependent ROC for the LIHC nomogram showed AUCs of 0.711, 0.649, and 0.653 at 1, 3, and 5 years, respectively. GSEA indicated enrichment of PI3K-AKT-mTOR, MYC targets, and cell-cycle pathways in ATIC-high LIHC. High ATIC expression correlated with predicted increased sensitivity to sorafenib, doxorubicin, cisplatin, epothilone, and mitomycin in the TCGA-LIHC cohort.
DISCUSSION: ATIC upregulation across cancers links to tumor progression, immune modulation, and prognosis (LIHC), suggesting oncogenic roles in pan-cancer contexts. TCGA multi-omics show ATIC associates with immune/molecular subtypes, MSI/TMB/neoantigens, and predicts drug sensitivity, indicating diagnostic/prognostic potential.
CONCLUSION: ATIC is broadly upregulated across cancers and functions as an independent prognostic biomarker in LIHC. The ATIC-integrated nomogram shows modest predictive accuracy for LIHC survival. Our results implicate ATIC in oncogenic signaling (PI3K-AKT-mTOR, MYC, and cell-cycle) and suggest ATIC as a candidate biomarker to guide targeted and chemotherapeutic strategies in LIHC. Further in vitro and in vivo validation is warranted.
PMID:42152649 | DOI:10.2174/0115665240438824260113042223
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Nature - Issue - nature.com science feeds
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Imaging interface-controlled bulk oxygen spillover
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10324-xIn situ microscopic single-particle imaging demonstrates the significance of rationally engineered metal–support interfaces for activating the oxygen in bulk catalyst, helping elucidate reaction pathways in catalytic conversions.
Imaging interface-controlled bulk oxygen spillover
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10324-x
In situ microscopic single-particle imaging demonstrates the significance of rationally engineered metal–support interfaces for activating the oxygen in bulk catalyst, helping elucidate reaction pathways in catalytic conversions.-
cs.AI, q-bio.NC updates on arXiv.org
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Document Parsing Unveiled: Techniques, Challenges, and Prospects for Structured Information Extraction
arXiv:2410.21169v5 Announce Type: replace-cross Abstract: Document parsing (DP) transforms unstructured or semi-structured documents into structured, machine-readable representations, enabling downstream applications such as knowledge base construction and retrieval-augmented generation (RAG). This survey provides a comprehensive and timely review of document parsing research. We propose a systematic taxonomy that organizes existing approaches into modular pipeline-based systems and unified mod
Document Parsing Unveiled: Techniques, Challenges, and Prospects for Structured Information Extraction
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cs.AI, q-bio.NC updates on arXiv.org
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Infeasibility Aware Large Language Models for Combinatorial Optimization
arXiv:2604.01455v1 Announce Type: new Abstract: Large language models (LLMs) are increasingly explored for NP-hard combinatorial optimization problems, but most existing methods emphasize feasible-instance solution generation and do not explicitly address infeasibility detection. We propose an infeasibility-aware framework that combines certifiable dataset construction, supervised fine-tuning, and LLM-assisted downstream search. For the minor-embedding problem, we introduce a new mathematical p
Infeasibility Aware Large Language Models for Combinatorial Optimization
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cs.AI, q-bio.NC updates on arXiv.org
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ContextBudget: Budget-Aware Context Management for Long-Horizon Search Agents
arXiv:2604.01664v1 Announce Type: new Abstract: LLM-based agents show strong potential for long-horizon reasoning, yet their context size is limited by deployment factors (e.g., memory, latency, and cost), yielding a constrained context budget. As interaction histories grow, this induces a trade-off between retaining past information and staying within the context limit. To address this challenge, we propose Budget-Aware Context Management (BACM), which formulates context management as a sequen
ContextBudget: Budget-Aware Context Management for Long-Horizon Search Agents
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Oncogene - Issue - nature.com science feeds
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STAT3-mediated transactivation of NOVA2 promotes lung adenocarcinoma metastasis by splicing SMAD4
Oncogene, Published online: 01 April 2026; doi:10.1038/s41388-026-03752-6STAT3-mediated transactivation of NOVA2 promotes lung adenocarcinoma metastasis by splicing SMAD4
STAT3-mediated transactivation of NOVA2 promotes lung adenocarcinoma metastasis by splicing SMAD4
Oncogene, Published online: 01 April 2026; doi:10.1038/s41388-026-03752-6
STAT3-mediated transactivation of NOVA2 promotes lung adenocarcinoma metastasis by splicing SMAD4-
MRD
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Consensus statement on ctDNA minimal residual disease (MRD) testing in early-stage NSCLC - A Delphi study by the Asian Thoracic Oncology Research Group (ATORG)
J Thorac Oncol. 2026 Mar 26:103696. doi: 10.1016/j.jtho.2026.103696. Online ahead of print.ABSTRACTINTRODUCTION: Minimal residual disease (MRD) detection using liquid biopsy is an emerging tool for risk stratification and monitoring for recurrence in resected early-stage NSCLC. There is increasing need for clear guidance on its optimal clinical implementation.METHODS: The Asian Thoracic Oncology Research Group (ATORG) convened a multi-disciplinary panel of 27 experts to develop a consensus state
Consensus statement on ctDNA minimal residual disease (MRD) testing in early-stage NSCLC - A Delphi study by the Asian Thoracic Oncology Research Group (ATORG)
J Thorac Oncol. 2026 Mar 26:103696. doi: 10.1016/j.jtho.2026.103696. Online ahead of print.
ABSTRACT
INTRODUCTION: Minimal residual disease (MRD) detection using liquid biopsy is an emerging tool for risk stratification and monitoring for recurrence in resected early-stage NSCLC. There is increasing need for clear guidance on its optimal clinical implementation.
METHODS: The Asian Thoracic Oncology Research Group (ATORG) convened a multi-disciplinary panel of 27 experts to develop a consensus statement on the clinical application of ctDNA-based MRD testing in early-stage resected NSCLC, using a structured Delphi methodology. Statements were organized into broad thematic domains: Assay validity and standardization; Harmonization in research and trials; Clinical application; Challenges in implementation; Consensus recommendations; Infrastructure for regional MRD adoption; and Roadmap for pragmatic trials.
RESULTS: A total of 23 position statements were developed, of which all except one achieved strong consensus. The consensus highlighted the need to define minimum analytical performance thresholds for MRD assays, improve standardization of reporting metrics, and clear guidelines for pre-analytical handling. Harmonization of blood sampling timepoints and terminology across clinical trials is also essential to confirm the prognostic value of MRD assays. While current MRD assays demonstrate high specificity and positive predictive value, variable sensitivity precludes routine use for adjuvant therapy de-escalation outside clinical trials. Broader access, sustainable funding, ongoing consensus building and collaborative real-world data generation are also critical to support clinical implementation and adoption. Future clinical trials must account for the distinct biology and changing standards of care associated with different driver genes.
CONCLUSION: These consensus recommendations provide a pragmatic framework to guide the responsible integration of MRD testing into clinical research and practice.
PMID:41903701 | DOI:10.1016/j.jtho.2026.103696
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cs.AI, q-bio.NC updates on arXiv.org
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Annealed Co-Generation: Disentangling Variables via Progressive Pairwise Modeling
arXiv:2603.06615v1 Announce Type: cross Abstract: For multivariate co-generation in scientific applications, we advocate pairwise block rather than joint modeling of all variables. This design mitigates the computational burden and data imbalance. To this end, we propose an Annealed Co-Generation (ACG) framework that replaces high-dimensional diffusion modeling with a low-dimensional diffusion model, which enables multivariate co-generation by composing pairwise variable generations. We first t
Annealed Co-Generation: Disentangling Variables via Progressive Pairwise Modeling
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cs.AI, q-bio.NC updates on arXiv.org
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HybridStitch: Pixel and Timestep Level Model Stitching for Diffusion Acceleration
arXiv:2603.07815v1 Announce Type: cross Abstract: Diffusion models have demonstrated a remarkable ability in Text-to-Image (T2I) generation applications. Despite the advanced generation output, they suffer from heavy computation overhead, especially for large models that contain tens of billions of parameters. Prior work has illustrated that replacing part of the denoising steps with a smaller model still maintains the generation quality. However, these methods only focus on saving computation
HybridStitch: Pixel and Timestep Level Model Stitching for Diffusion Acceleration
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cs.AI, q-bio.NC updates on arXiv.org
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Taming Modality Entanglement in Continual Audio-Visual Segmentation
arXiv:2510.17234v2 Announce Type: replace-cross Abstract: Recently, significant progress has been made in multi-modal continual learning, aiming to learn new tasks sequentially in multi-modal settings while preserving performance on previously learned ones. However, existing methods mainly focus on coarse-grained tasks, with limitations in addressing modality entanglement in fine-grained continual learning settings. To bridge this gap, we introduce a novel Continual Audio-Visual Segmentation (C
Taming Modality Entanglement in Continual Audio-Visual Segmentation
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cs.AI, q-bio.NC updates on arXiv.org
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Rethinking Driving World Model as Synthetic Data Generator for Perception Tasks
arXiv:2510.19195v4 Announce Type: replace-cross Abstract: Recent advancements in driving world models enable controllable generation of high-quality RGB videos or multimodal videos. Existing methods primarily focus on metrics related to generation quality and controllability. However, they often overlook the evaluation of downstream perception tasks, which are $\mathbf{really\ crucial}$ for the performance of autonomous driving. Existing methods usually leverage a training strategy that first p
Rethinking Driving World Model as Synthetic Data Generator for Perception Tasks
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cs.AI, q-bio.NC updates on arXiv.org
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CoFL: Continuous Flow Fields for Language-Conditioned Navigation
arXiv:2603.02854v1 Announce Type: cross Abstract: Language-conditioned navigation pipelines often rely on brittle modular components or costly action-sequence generation. To address these limitations, we present CoFL, an end-to-end policy that directly maps a bird's-eye view (BEV) observation and a language instruction to a continuous flow field for navigation. Instead of predicting discrete action tokens or sampling action chunks via iterative denoising, CoFL outputs instantaneous velocities t
CoFL: Continuous Flow Fields for Language-Conditioned Navigation
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cs.AI, q-bio.NC updates on arXiv.org
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AlphaForgeBench: Benchmarking End-to-End Trading Strategy Design with Large Language Models
arXiv:2602.18481v1 Announce Type: cross Abstract: The rapid advancement of Large Language Models (LLMs) has led to a surge of financial benchmarks, evolving from static knowledge tests to interactive trading simulations. However, current evaluations of real-time trading performance overlook a critical failure mode: severe behavioral instability in sequential decision-making under uncertainty. We empirically show that LLM-based trading agents exhibit extreme run-to-run variance, inconsistent act
AlphaForgeBench: Benchmarking End-to-End Trading Strategy Design with Large Language Models
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cs.AI, q-bio.NC updates on arXiv.org
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Synthesizing Multimodal Geometry Datasets from Scratch and Enabling Visual Alignment via Plotting Code
arXiv:2602.18745v1 Announce Type: cross Abstract: Multimodal geometry reasoning requires models to jointly understand visual diagrams and perform structured symbolic inference, yet current vision--language models struggle with complex geometric constructions due to limited training data and weak visual--symbolic alignment. We propose a pipeline for synthesizing complex multimodal geometry problems from scratch and construct a dataset named \textbf{GeoCode}, which decouples problem generation in