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How Should LLMs Consume High-Quality Data? Optimal Data Scheduling via Quality-Aware Functional Scaling Laws

arXiv:2605.25698v1 Announce Type: cross Abstract: High-quality data is scarce in large language model (LLM) training, yet how to schedule its use jointly with training dynamics lacks theoretical guidance. We extend functional scaling laws by incorporating a data-quality dimension, and solve the joint data-quality and batch-size scheduling problem in asymptotic closed form. The solution reveals two regimes and a dual role of high-quality data. In the noise-limited regime, high-quality data should be used as a signal amplifier: lowering the batch size converts cleaner data into more signal without amplifying noise. In the signal-limited regime, it should be used as a noise suppressor: late placement reduces terminal noise without sacrificing signal accumulation. Existing curriculum-style pipelines primarily exploit the second role by placing cleaner data late, but miss the first role because conventional decay schedules reduce update intensity exactly when high-quality data becomes available. Guided by this, we propose Drop-Stable-Rampup for LLM midtraining: upon the quality transition, drop the batch size, hold it stable to accumulate signal, then ramp up to suppress terminal noise. On a 15B Mixture-of-Experts model midtrained on 108B tokens, Drop-Stable-Rampup improves average accuracy over Warmup-Stable-Decay (WSD) by +1.70 and over Cosine-decay by +2.98, with particularly large gains on mathematical reasoning benchmarks such as GSM8K (+4.23) and MATH (+2.80).

ATP2B4 driven chromatin compaction exacerbates pancreatic cancer radiotherapy resistance

Cell Death Discovery, Published online: 25 May 2026; doi:10.1038/s41420-026-03142-7

ATP2B4 driven chromatin compaction exacerbates pancreatic cancer radiotherapy resistance

PIAS4 inhibition induces cell cycle arrest and exhibits a synergistic effect in combination with CDK4/6 inhibitor in breast cancer treatment

Oncogene, Published online: 07 April 2026; doi:10.1038/s41388-026-03753-5

PIAS4 inhibition induces cell cycle arrest and exhibits a synergistic effect in combination with CDK4/6 inhibitor in breast cancer treatment

MultiGA: Leveraging Multi-Source Seeding in Genetic Algorithms

arXiv:2512.04097v2 Announce Type: replace-cross Abstract: In this paper, we introduce, MultiGA, an optimization framework which applies genetic algorithm principles to address complex natural language tasks and reasoning problems by sampling from a diverse population of LLMs to initialize the population of candidate solutions. MultiGA generates a range of outputs from various parent LLMs and uses a neutral fitness function to evaluate them. Through an iterative recombination process, we mix and refine these generations until an optimal solution is achieved. Our results show that MultiGA produces high accuracy across multiple benchmarks, and these insights lay the foundation for future research looking closer at integrating multiple LLMs for unexplored tasks in which selecting only one pre-trained model is unclear or suboptimal.

Restoration Adaptation for Semantic Segmentation on Low Quality Images

arXiv:2602.14042v1 Announce Type: cross Abstract: In real-world scenarios, the performance of semantic segmentation often deteriorates when processing low-quality (LQ) images, which may lack clear semantic structures and high-frequency details. Although image restoration techniques offer a promising direction for enhancing degraded visual content, conventional real-world image restoration (Real-IR) models primarily focus on pixel-level fidelity and often fail to recover task-relevant semantic cues, limiting their effectiveness when directly applied to downstream vision tasks. Conversely, existing segmentation models trained on high-quality data lack robustness under real-world degradations. In this paper, we propose Restoration Adaptation for Semantic Segmentation (RASS), which effectively integrates semantic image restoration into the segmentation process, enabling high-quality semantic segmentation on the LQ images directly. Specifically, we first propose a Semantic-Constrained Restoration (SCR) model, which injects segmentation priors into the restoration model by aligning its cross-attention maps with segmentation masks, encouraging semantically faithful image reconstruction. Then, RASS transfers semantic restoration knowledge into segmentation through LoRA-based module merging and task-specific fine-tuning, thereby enhancing the model's robustness to LQ images. To validate the effectiveness of our framework, we construct a real-world LQ image segmentation dataset with high-quality annotations, and conduct extensive experiments on both synthetic and real-world LQ benchmarks. The results show that SCR and RASS significantly outperform state-of-the-art methods in segmentation and restoration tasks. Code, models, and datasets will be available at https://github.com/Ka1Guan/RASS.git.
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