arXiv:2609.09646v1 Announce Type: new Abstract: Semantic-gradient-based prompt optimization (SGPO) improves agent harnesses using execution feedback, but its local update rule leaves the choice of edit scope and operation unresolved. We introduce RobustSGPO, which specifies the requested edit, constructs and checks the patch, and continues search from either the incumbent or retained snapshots. We evaluate permission scheduling, cumulative controls, and task-family transfer in the AgentX brainstorming workflow using 120 tasks, 95 runs, and 7,350 candidate attempts. Periodic $1\to2\to3$ scheduling exceeds fixed maximum permission by 0.28 test-score points. RobustSGPO increases completion on 30 held-out tasks from 60.0% to 80.0% and improves test quality from 3.77 to 4.14 under a 20-million-token budget. Category retention reduces source-task degradation after a shift, whereas random retention reaches a higher destination endpoint. Search-space control benefits quality through executable edits and alternative starting points, with measurable retention overhead.

Oncogene, Published online: 19 May 2026; doi:10.1038/s41388-026-03823-8

NDRG2 orchestrates circadian clock stability to suppress tumorigenesis and potentiate oxaliplatin response in colorectal cancer

arXiv:2604.02183v1 Announce Type: new Abstract: Multimodal recommendation systems (MRS) jointly model user-item interaction graphs and rich item content, but this tight coupling makes user data difficult to remove once learned. Approximate machine unlearning offers an efficient alternative to full retraining, yet existing methods for MRS mainly rely on a largely uniform reverse update across the model. We show that this assumption is fundamentally mismatched to modern MRS: deleted-data influence is not uniformly distributed, but concentrated unevenly across \textit{ranking behavior}, \textit{modality branches}, and \textit{network layers}. This non-uniformity gives rise to three bottlenecks in MRS unlearning: target-item persistence in the collaborative graph, modality imbalance across feature branches, and layer-wise sensitivity in the parameter space. To address this mismatch, we propose \textbf{targeted reverse update} (TRU), a plug-and-play unlearning framework for MRS. Instead of applying a blind global reversal, TRU performs three coordinated interventions across the model hierarchy: a ranking fusion gate to suppress residual target-item influence in ranking, branch-wise modality scaling to preserve retained multimodal representations, and capacity-aware layer isolation to localize reverse updates to deletion-sensitive modules. Experiments across two representative backbones, three datasets, and three unlearning regimes show that TRU consistently achieves a better retain-forget trade-off than prior approximate baselines, while security audits further confirm deeper forgetting and behavior closer to a full retraining on the retained data.

Science, Ahead of Print.

β-hydroxybutyrate (BHB), the ketone body associated with a ketogenic diet, metabolically reprograms and fuels CAR T cells to achieve proliferation, cytokine production, and superior tumor control. These findings suggest that BHB supplementation may be a practical way to boost adoptive cancer immunotherapy.